Early diagnosis of HIV infection among men who have sex with men in Lima (Peru). A prospective cohort study

Coll, J; Videla, Sebastián; Ganoza, Carmela; Ornelas, Arelly; Perez, Santiago Fadul; Clotet, Bonaventura; Berthou, Christian; Sánchez, Jorge

doi:10.1016/j.cmi.2018.02.029

Cited by 2 publications

(4 citation statements)

References 5 publications

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“…Within the CTU, two clinics located in Lima served as our research sites, IMPACTA and CITBM. Both sites have demonstrated the ability to recruit and enroll a large number of MSM with and without HIV and AUD [ 19 – 21 ].…”

Section: Methodsmentioning

confidence: 99%

“…In areas with low internet connectivity, REDCap Mobile App is a feasible option for data capture and management [ 1 ]. In this study, we implemented the use of the REDCap Mobile App in two medical clinics known for their vast experience in HIV research in Peru: IMPACTA San Miguel Clinical Research Site (IMPACTA), and Centro de Investigaciones Tecnologías, Biomédicas y Medioambientales (CITBM) [ 19 – 21 ]. Specifically, we worked with IMPACTA and CITBM clinic tablets, allowing our study team to capture data with intermittent and unreliable internet access.…”

Section: Introductionmentioning

confidence: 99%

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Implementation of REDCap mobile app in an oral HIV clinical study

Seminario,

Karczewski,

Stanley

et al. 2024

BMC Public Health

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Background In Peru, HIV cases are highly concentrated among men who have sex with men (MSM). Despite the availability of anti-retroviral therapy, people living with HIV (PWH) have higher levels of oral diseases. Alcohol use disorder (AUD) is significantly present among PWH. Our overarching goal was to generate foundational evidence on the association of AUD and oral health in MSM with HIV and enhance research capacity for future intersectional research on AUD, oral health and HIV. Our specific aim was to implement an on-site electronic data collection system through the use of a REDCap Mobile App in a low-middle income country (LMIC) setting. Methods Five validated surveys were utilized to gather data on demographics, medical history, HIV status, alcohol use, HIV stigma, perceived oral health status, and dietary supplement use. These surveys were developed in REDCap and deployed with the REDCap Mobile App, which was installed on ten iPads across two medical HIV clinics in Lima, Peru. REDCap app as well as the protocol for data collection were calibrated with feedback from trial participants and clinical research staff to improve clinical efficiency and participant experience. Results The mean age of participants (n = 398) was 35.94 ± 9.13y, of which 98.5% identified as male, and 85.7% identified as homosexual. 78.1% of participants binge drank, and 12.3% reported being heavy drinkers. After pilot testing, significant modifications to the structure and layout of the surveys were performed to improve efficiency and flow. The app was successfully deployed to replace cumbersome paper records and collected data was directly stored in a REDCap database. Conclusions The REDCap Mobile App was successfully used due to its ability to: (a) capture and store data offline, (b) timely translate between multiple languages on the mobile app interface, and (c) provide user-friendly interface with low associated costs and ample support. Trial registration 1R56DE029639-01.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Implementation of REDCap mobile app in an oral HIV clinical study

Seminario,

Karczewski,

Stanley

et al. 2024

BMC Public Health

View full text Add to dashboard Cite

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“…HIV-1 infected subjects were recruited from the HIV Clinics of two tertiary care hospitals, Germans Trias i Pujol and Vall d'Hebrón. HIV-negative controls were primarily recruited from a prospective cohort of HIV-negative (MSM) and were at risk of HIV-1 infection 22 .…”

Section: Methodsmentioning

confidence: 99%

“…This study included 156 subjects (Table 1) comprising 129 (82.7%) HIV-1 infected patients with different clinical pro les and 27 (17.3%) negative controls recruited in Barcelona, Spain, between January and December 2014. HIV-1 infected subjects were enrolled from two tertiary HIV-1 clinics and negative controls were recruited from a cohort of HIV-negative MSM at risk of becoming infected by HIV-1 attending a community centre and HIV-1-negative partners from HIV-1-infected subjects attending the HIV clinics 19,21,22 . Mean age of included patients was 43 years, most were male (79%) and of Caucasian ethnicity (79%).…”

Section: Study Populationmentioning

confidence: 99%

Gut resistome linked to Sexual Preference and HIV infection

Garcia,

Casadellà,

Parera

et al. 2023

Preprint

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Background: People living with HIV (PLWH) are at increased risk of acquisition of multidrug resistant organisms due to higher rates of predisposing factors. The gut microbiome is the main reservoir of the collection of antimicrobial resistance determinants known as the gut resistome. In PLWH, changes in gut microbiome have been linked to immune activation and HIV-1 associated complications. Specifically, gut dysbiosis defined by low microbial gene richness has been linked to low Nadir CD4+ T-cell counts. Additionally, sexual preference has been shown to strongly influence gut microbiome composition in PLWH resulting in different Prevotellaor Bacteroides enriched enterotypes, in MSM (men-who-have–sex-with-men) or no-MSM, respectively. To date, little is known about gut resistome composition in PLWH due to the scarcity of studies using shotgun metagenomics. The present study aimed to detect associations between different microbiome features linked to HIV-1 infection and gut resistome composition. Results: Using shotgun metagenomics we characterized the gut resistome composition of 129 HIV-1 infected subjects showing different HIV clinical profiles and 27 HIV-1 negative controls from a cross-sectional observational study conducted in Barcelona, Spain. Most no-MSM showed a Bacteroides-enriched enterotype and low microbial gene richness microbiomes. We did not identify differences in resistome diversity and composition according to HIV-1 infection or immune status. However, gut resistome was more diverse in MSM group, Prevotella-enriched enterotype and gut micorbiomes with high microbial gene richness compared to no-MSM group, Bacteroides-enriched enterotype and gut microbiomes with low microbial gene richness. Additionally, gut resistome beta-diversity was different according to the defined groups and we identified a set of differentially abundant antimicrobial resistance determinants based on the established categories. Conclusions: Our findings reveal a significant correlation between gut resistome composition and various host variables commonly associated with gut microbiome, including microbiome enterotype, microbial gene richness, and sexual preference. These host variables have been previously linked to immune activation and lower Nadir CD4+ T-Cell counts, which are prognostic factors of HIV-related comorbidities. This study provides new insights into the relationship between antibiotic resistance and clinical characteristics of PLWH.

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Early diagnosis of HIV infection among men who have sex with men in Lima (Peru). A prospective cohort study

Cited by 2 publications

References 5 publications

Implementation of REDCap mobile app in an oral HIV clinical study

Implementation of REDCap mobile app in an oral HIV clinical study

Gut resistome linked to Sexual Preference and HIV infection

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