Early diagnosis of lower respiratory tract infections (point-of-care tests)

Charles, Patrick G P

doi:10.1097/mcp.0b013e3282f7642f

Cited by 27 publications

(6 citation statements)

References 81 publications

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“…Viruses are responsible for the majority of respiratory infectious diseases in both children and adults, causing a massive disease burden [7,8]. Furthermore, the identification of causative viruses enables the accurate diagnosis of respiratory infections and prescription of specific antiviral agents against certain viruses, such as oseltamivir for influenza viruses, and improves evaluation of the prognosis [9][10][11]. Recognizing causative viruses can also provide information on the appropriate infection control measures, which can potentially reduce unnecessary hospital stays and allow discontinuation of unnecessary antibiotics [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Increased Detection of Viruses in Children with Respiratory Tract Infection Using PCR

Lin

Hwang

Chiu

et al. 2020

IJERPH

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Respiratory viruses are a common cause of respiratory tract infection (RTI), particularly in neonates and children. Rapid and accurate diagnosis of viral infections could improve clinical outcomes and reduce the use of antibiotics and treatment sessions. Advances in diagnostic technology contribute to the accurate detection of viruses. We performed a multiplex real-time polymerase chain reaction (PCR) to investigate the viral etiology in pediatric patients and compared the detection rates with those determined using traditional antigen tests and virus cultures. Fifteen respiratory viruses were included in our investigation: respiratory syncytial virus A/B (RSV), influenza virus A (FluA) and influenza virus B (FluB), human metapneumovirus (MPV), enterovirus (EV), human parainfluenza virus (PIV) types 1-4, human rhinovirus (RV), human coronavirus OC43, NL63, and 229E, human adenovirus (ADV), and human bocavirus (Boca). In total, 474 specimens were collected and tested. Respiratory viruses were detected more frequently by PCR (357, 75.3%) than they were by traditional tests (229, 49.3%). The leading pathogens were RSV (113, 23.8%), RV (72, 15.2%), PIV3 (53, 11.2%), FluA (51, 10.8%), and ADV (48, 10.1%). For children younger than 5 years, RSV and RV were most prevalent; for children older than 5 years, FluA and ADV were the most frequently detected. Of the specimens, 25.8% (92/357) were coinfected with two or more viruses. RV, Boca, PIV2, FluB, and PIV4 had higher rates of coinfection; MPV and PIV1 had the lowest rates of coinfection (9.1% and 5.3%). To conclude, the detection power of PCR was better than that of traditional antigen tests and virus cultures when considering the detection of respiratory viruses. RSV and RV were the leading viral pathogens identified in the respiratory specimens. One-quarter of the positive specimens were coinfected with two or more viruses. In the future, further application of PCR may contribute to the rapid and accurate diagnosis of respiratory viruses and could improve patient outcomes.

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Section: Introductionmentioning

confidence: 99%

Increased Detection of Viruses in Children with Respiratory Tract Infection Using PCR

Lin

Hwang

Chiu

et al. 2020

IJERPH

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“…RAT has specifically been shown to reduce unnecessary antibiotic usage (8,14,17), and its use helps to effectively manage hospital bed utilization (1). Thus, the rapid and accurate detection of influenza and differentiation from other etiologic agents of influenza-like illnesses are useful for several aspects of patient management (7,12).…”

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confidence: 99%

Analytical and Clinical Sensitivity of the 3M Rapid Detection Influenza A+B Assay

Dale¹,

Mayer

et al. 2008

J Clin Microbiol

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The performance of the 3M rapid detection influenza A؉B (3M flu) assay was compared to the performance of other immunochromatographic assays. The clinical and analytical performance of the 3M flu assay was superior to that of BinaxNOW and Directigen EZ assays and equivalent to that of the QuickVue assay. The 3M flu assay offers an objective output and direct linkage to laboratory information systems.

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“…The use of POC devices by the above mentioned target groups would provide tangible benefits for all concerned, including more accurate, rapid, and cheaper diagnosis of microbiological infections, whilst providing accompanying advantages with respect to national healthcare budgets; eg, by facilitating earlier discharge from hospital and helping reduce the use of staff and equipment,9–11 and for example by shifting the burden of healthcare from healthcare providers to the actual patients themselves. Further, such market developments could provide significant advances with respect to limiting the ever growing threat of antimicrobial resistance and its impact on patient morbidity and mortality 12,13. In fact, the administration of suitable antibiotic therapy in the early onset of an infectious disease has been shown to improve the outcome of critically ill patients, with guidelines being available for the prescription of empirical antimicrobial therapy; ie, the prescribing of antimicrobial therapy before culture results become available 14.…”

Section: Introductionmentioning

confidence: 99%

Perceptions of point-of-care infectious disease testing among European medical personnel, point-of-care test kit manufacturers, and the general public

Kaman¹,

Andrinopoulou²,

Hays³

2013

PPA

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BackgroundThe proper development and implementation of point-of-care (POC) diagnostics requires knowledge of the perceived requirements and barriers to their implementation. To determine the current requirements and perceived barriers to the introduction of POC diagnostics in the field of medical microbiology (MM)-POC a prospective online survey (TEMPOtest-QC) was established.Methods and resultsThe TEMPOtest-QC survey was online between February 2011 and July 2012 and targeted the medical community, POC test diagnostic manufacturers, general practitioners, and the general public. In total, 293 individuals responded to the survey, including 91 (31%) medical microbiologists, 39 (13%) nonmedical microbiologists, 25 (9%) employees of POC test manufacturers, and 138 (47%) members of the general public. Responses were received from 18 different European countries, with the largest percentage of these living in The Netherlands (52%). The majority (>50%) of medical specialists regarded the development of MM-POC for blood culture and hospital acquired infections as “absolutely necessary”, but were much less favorable towards their use in the home environment. Significant differences in perceptions between medical specialists and the general public included the: (1) Effect on quality of patient care; (2) Ability to better monitor patients; (3) Home testing and the doctor-patient relationship; and (4) MM-POC interpretation. Only 34.7% of the general public is willing to pay more than a€10 ($13) for a single MM-POC test, with 85.5% preferring to purchase their MM-POC test from a pharmacy.ConclusionThe requirements for the proper implementation of MM-POC were found to be generally similar between medical specialists and POC test kit manufacturers. The general public was much more favorable with respect to a perceived improvement in the quality of healthcare that these tests would bring to the hospital and home environment.

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Early diagnosis of lower respiratory tract infections (point-of-care tests)

Abstract: Although the sensitivities of many of the rapid diagnostic tests are moderate, when used at the time of initial consultation, they have the potential to reduce costs, length of stay, secondary spread of respiratory viruses, and inappropriate antibiotic prescribing.

Cited by 27 publications

References 81 publications

Increased Detection of Viruses in Children with Respiratory Tract Infection Using PCR

Increased Detection of Viruses in Children with Respiratory Tract Infection Using PCR

Analytical and Clinical Sensitivity of the 3M Rapid Detection Influenza A+B Assay

Perceptions of point-of-care infectious disease testing among European medical personnel, point-of-care test kit manufacturers, and the general public

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