Early Diagnosis of Ovarian Carcinoma: Is a Solution in Sight?

Lutz, A.M.; Willmann, Jürgen K.; Ray, Pritha; Cochran, Frank V.; Urban, Nicole; Gambhir, Sanjiv S.

doi:10.1148/radiol.11090563

Cited by 82 publications

(90 citation statements)

References 132 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, we found that CT could detect adnexal masses quite successfully, with a 93% sensitivity and a 70% specificity, as is consistent with previous reports, but it does not show sufficient sensitivity and specificity to determine local tumor dispersion like uterine and tubal involvement, pelvic fat plan obliteration and bladder metastases [5,19,20]. As it has been suggested before, we think MRI may yield more useful results regarding these areas [21,22].…”

Section: Discussionsupporting

confidence: 86%

Computed tomography as a predictor of the extent of the disease and surgical outcomes in ovarian cancer

Cerci

Sakarya²,

Yetimalar³

et al. 2016

Ginekol Pol

View full text Add to dashboard Cite

Objectives: The aim of the present study is to determine the predictive value of Computed Tomography (CT), alone or in combination with serum CA-125 levels, for preoperative staging, detection of the extent of the disease, and surgical complications in patients with ovarian carcinoma. Material and methods:One hundred and fourteen patients diagnosed with ovarian carcinoma following an exploratory laparotomy with a preoperative CT scan, performed between January 2007 and June 2013, were enrolled in the study. Preoperative CT and intraoperative surgical findings were compared using 14 parameters and predictions of CT for gastrointestinal, genitourinary, and cardiovascular complications. All radiological features and clinical characteristics were analyzed statistically.Results: CT and surgical findings correlated (sensitivity/ specificity) as follows: uterine and tubal spread (66%/89%), cervical involvement (100%/80%), peritoneal nodulesincreased density-carcinomatosis (57%/93%), omental involvement (68%/95%), retroperitoneal involvement (25%/84%), ascites (85%/87%), perirectal and perivesical fat plan obliteration (43%/94%), liver metastasis (50%/91%), small and large bowel involvement (47%/95%), adnexal mass (94%/70%), and other metastases (47%/86%). Also, CT findings were found to be statistically insignificant for prediction of mesenteric involvement, bladder metastasis, and diaphragmatic involvement. The overall CT sensitivity and specificity at detecting intraoperative findings was 91% and 71%, respectively. We found a statistically significant correlation between intestinal involvement on CT and the necessity of additional surgical procedures. Conclusions:CT is a widely used imaging method in the preoperative evaluation of ovarian cancer. However, its predictive value, sensitivity and specificity differ, depending on the anatomical region.

show abstract

Section: Discussionsupporting

confidence: 86%

Computed tomography as a predictor of the extent of the disease and surgical outcomes in ovarian cancer

Cerci

Sakarya²,

Yetimalar³

et al. 2016

Ginekol Pol

View full text Add to dashboard Cite

show abstract

“…The system was able to differentiate normal postmenopausal versus malignant postmenopausal (P = .0237) ovaries, with sensitivity and specificity of 83% and 83%, respectively, while no significant differences were found between normal premenopausal versus normal postmenopausal (P = .2361) ovaries (Fig 9). The group (113,114) later reported of ovarian cancer are ineffective, with poor sensitivity and specificity (110). A large randomized multicenter clinical trial (111) performed in the United States to determine the effect of screening on ovarian cancer mortality concluded that simultaneous screening with CA-125 (serum biomarker for ovarian cancer) and transvaginal US did not reduce ovarian cancer mortality when compared with usual care.…”

Section: Review: Photoacoustic Imaging In Oncologymentioning

confidence: 99%

Photoacoustic Imaging in Oncology: Translational Preclinical and Early Clinical Experience

Valluru¹,

Wilson²,

Willmann³

2016

Radiology

Self Cite

166

107

View full text Add to dashboard Cite

“…On the other hand, early-and middle-stage ovarian cancer is rarely detected due to the lack of reliable tools and biomarkers (Lutz et al, 2011). Even for the advanced-stage disease, being short of sensitive biomarkers has become a big obstacle for the estimate of intervention therapies and the monitoring of metastatic tumor tissue.…”

Section: Introductionmentioning

confidence: 99%

ATAD2 is Highly Expressed in Ovarian Carcinomas and Indicates Poor Prognosis

Wan¹,

Zhang²,

Wang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

The purpose of this study was to explore the expression of ATAD2 in ovarian tumor tissue as well as its relationship with degree of malignancy. Tumor tissue from 110 cases of ovarian cancer was collected in accordance with the Declaration of Helsinki for evaluation of ATAD2 expression iimmunohistochemistry, quantitative PCR (qPCR) and Western blotting. The correlation between the ATAD2 expression and and the prognosis of ovarian cancer was evaluated by Cox regression model. In addition, HO-8910 and OVCAR-3 cells were transfected with two siRNAs targeting ATAD2. Cell viability was evaluated with MTT assay, and cell migration by transwell migration assay. ATAD2 was shown to be highly expressed in 65.5% (72/110) of ovarian cancer cases, both at transcriptional and protein levels. Moreover, highly expression was positively correlated with degree of malignancy. Knock-down of ATAD2 in HO-8910 and OVCAR-3 cells was found to reduce cell migration. In addition, follow-up visits of the patients demonstrated that the 5-year survival rate was lower in patients with high expression of ATAD2. Our study suggested that ovarian tumor tissue may have highly expressed ATAD2, which is associated with tumor stage, omentum-metastasis, ascites and CA-125. Increased ATAD2 may play important roles in tumor proliferation and migration. ATAD2 could serve in particular as a prognostic marker and a therapeutic target for ovarian cancer.

show abstract

Early Diagnosis of Ovarian Carcinoma: Is a Solution in Sight?

Abstract: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.11090563/-/DC1.

Cited by 82 publications

References 132 publications

Computed tomography as a predictor of the extent of the disease and surgical outcomes in ovarian cancer

Computed tomography as a predictor of the extent of the disease and surgical outcomes in ovarian cancer

Photoacoustic Imaging in Oncology: Translational Preclinical and Early Clinical Experience

ATAD2 is Highly Expressed in Ovarian Carcinomas and Indicates Poor Prognosis

Contact Info

Product

Resources

About