Early Diagnosis of the Strangulated Obstruction.

Yamagishi, Shigeru; Yamaguchi, Shigeki; Kimura, Hideaki; Fujii, Shouichi; Moriwaki, Yoshihiro; Mochizuki, Hirohiko; Ichikawa, Yasushi; Ike, Hideyuki; Ohki, Shigeo; Shimada, Hiroshi

doi:10.5833/jjgs.36.11

Cited by 5 publications

(3 citation statements)

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“…To the best of our knowledge, there have been few reports on factors involved in the diagnosis of strangulation ileus using univariate or multivariate analysis. Yamagishi et al [7] analyzed the factors involved in the diagnosis of strangulation ileus using multivariate analysis and reported that the peritoneal irritation sign, presence of ascites, and PaCO 2 were the significant independent factors. According to some reports [7][8][9], the incidence of peritoneal irritation sign in strangulation ileus is 40-60% and the diagnosis of such a sign requires experience as a clinician.…”

Section: Discussionmentioning

confidence: 99%

“…Yamagishi et al [7] analyzed the factors involved in the diagnosis of strangulation ileus using multivariate analysis and reported that the peritoneal irritation sign, presence of ascites, and PaCO 2 were the significant independent factors. According to some reports [7][8][9], the incidence of peritoneal irritation sign in strangulation ileus is 40-60% and the diagnosis of such a sign requires experience as a clinician. Also, since the effects of analgesic drugs should be taken into consideration, the peritoneal irritation sign is not a very effective factor for the diagnosis of strangulation ileus.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of sequential organ failure assessment score for patients with strangulation ileus

Sumi

Katsumata

Tsuchida

et al. 2008

Langenbecks Arch Surg

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Background We examined the effectiveness of sequential organ failure assessment (SOFA) score to describe patients with strangulation ileus. Methods The subjects consisted of 66 patients given a diagnosis of ileus who underwent a surgery during the period from January 2001 to December 2006. On the basis of surgical findings, they were classified into two groups; the strangulation group, consisting of 25 patients, and the control group, consisting of 41 patients with simple ileus. The background factors, SOFA score, blood test findings before treatment, and vital signs were compared between these two groups in a retrospective study. Results Statistically significant differences between the two groups were observed by univariate analysis in the SOFA score, white blood cell count, CRP, CPK, PaCO2, BE, and pulse rate. The SOFA score, white blood cell count, and pulse rate were significant independent factors in the multivariate analysis.Conclusions These results showed that it may be helpful to use SOFA score in combination with further diagnostic tools, while the experience of clinicians will be still required for diagnosis of strangulation ileus.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of sequential organ failure assessment score for patients with strangulation ileus

Sumi

Katsumata

Tsuchida

et al. 2008

Langenbecks Arch Surg

View full text Add to dashboard Cite

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“…Patients with SBS need emergency surgery because the ischemic small bowel can become necrotic in a short time, causing sepsis and death. Early diagnosis can prevent bowel necrosis and improve the prognosis [1], but clinical diagnosis is still very difficult, and its mortality rate is very high, ranging from 20 to 40% [2]. Nowadays the "gold standard" for diagnosing SBS is via contrast enhanced computed tomography (CT) scanned images [2]- [4].…”

Section: Introductionmentioning

confidence: 99%

Detecting Small Bowel Strangulation using Circulating Cell-Free DNA with Machine Learning

Nishiwaki

Yamada

Iwai

et al. 2017

IJMLC

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Small bowel obstruction is a common acute abdomen condition which can play a role in death. Small bowel strangulation (SBS) refers to a small bowel obstruction associated with bowel ischemia. Patients with SBS need emergency surgery because the ischemic small bowel can become necrotic in a short time, causing sepsis and death. Nowadays the "gold standard" for diagnosing SBS is via computed tomography (CT) scanned images. However, an easier way to detect SBS is desired among emergency medicine physicians. Thus, we tried to develop a rapid test using circulating cell-free DNA (ccfDNA). ccfDNA is part of the DNA from a cell that died because of apoptosis or necrosis. The size of ccfDNA varies depending on the origination of cell death. If a patient has SBS, long-size ccfDNA would appear in the peripheral blood. We used data including the concentration of ccfDNA in the blood of certain patients as training data to make a support vector machine, a decision tree, and a learned random forest. We evaluated these classifiers using leave-one-out cross-validation. These machine-learning methods performed well. In addition, the decision tree and random forest results indicate that long-size ccfDNA is important for classifying SBS. In this paper, we demonstrate that machine learning can be an alternative method for detecting SBS and that the concentration of ccfDNA, especially long ccfDNA, contributes to detecting SBS.

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