1977
DOI: 10.1136/hrt.39.8.900
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Early diastolic murmurs in end-stage renal failure.

Abstract: An early diastolic murmur thought to indicate functional aortic regurgitation was heard in 7 of 74 consecutive patients with end-stage renal failure assessed for chronic intermittent haemodialysis and transplantation. In all 7 cases the murmur was transient and related to episodes of hypertension and fluid overload and disappeared on correction of these factors. In a further 2 patients aortic regurgitation resulted from a structural abnormality of the aortic valve. Thus, an early diastolic murmur is not uncomm… Show more

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Cited by 5 publications
(3 citation statements)
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“…The clinical context of a diastolic murmur is important, as patients with end stage renal failure and volume overload may have transient early diastolic murmurs that resolve with correction of volume overload. 146 The physical examination is of limited value in assessing the severity of aortic regurgitation. However, severe aortic regurgitation is unlikely with very quiet (grade 1) murmurs (LR+ 0, 0 to 0.9) and more likely when either a third heart sound (LR+ 5.9, 1.4 to 25) or grade 3 murmur (LR+ 4.5, 1.6 to 14) is present.…”
Section: Tricuspid Regurgitationmentioning
confidence: 99%
“…The clinical context of a diastolic murmur is important, as patients with end stage renal failure and volume overload may have transient early diastolic murmurs that resolve with correction of volume overload. 146 The physical examination is of limited value in assessing the severity of aortic regurgitation. However, severe aortic regurgitation is unlikely with very quiet (grade 1) murmurs (LR+ 0, 0 to 0.9) and more likely when either a third heart sound (LR+ 5.9, 1.4 to 25) or grade 3 murmur (LR+ 4.5, 1.6 to 14) is present.…”
Section: Tricuspid Regurgitationmentioning
confidence: 99%
“…When a cardiologist hears the murmur of PR, the likelihood of PR increases (positive LR, 17 in both studies), but absence of a PR murmur was not helpful for ruling out PR (LR, 0.9 in both studies). 37,43 51 These murmurs typically disappear after the treatment of volume overload, as was demonstrated in 2 small studies (grade C). 51,52 These murmurs are probably due to transient pulmonary hypertension and dilation of the pulmonary artery root, leading to PR.…”
Section: Mitral Stenosis and Prmentioning
confidence: 67%
“…37,43 51 These murmurs typically disappear after the treatment of volume overload, as was demonstrated in 2 small studies (grade C). 51,52 These murmurs are probably due to transient pulmonary hypertension and dilation of the pulmonary artery root, leading to PR. 52…”
Section: Mitral Stenosis and Prmentioning
confidence: 67%