Early Discontinuation of Cow's Milk Protein Ingestion Is Associated with the Development of Cow's Milk Allergy

Sakihara, Tetsuhiro; Otsuji, Kenta; Arakaki, Yohei; Hamada, Kazuya; Sugiura, Shiro; Ito, Komei

doi:10.1016/j.jaip.2021.07.053

Cited by 32 publications

(13 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…26 , 28 No use of cow's milk formula supplementation in the first days of life in breastfed infants were recommended by 2 CPGs updated in 2021–2022 27 , 28 after release of findings from a RCT regarding cow's milk supplementation on the subsequent development of cow's milk protein allergy. 51 , 53 …”

Section: Resultsmentioning

confidence: 99%

“…Since then, RCT publications from Sakihara et al in 2021 and 2022 reported that daily ingestion of cow's milk formula between 1 and 2 months of age was protective against cow's milk allergy, 51 and that early discontinuation after initial introduction, particularly in the first month of life, was instead associated with increased risk of cow's milk allergy. 53 …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A systematic review of quality and consistency of clinical practice guidelines on the primary prevention of food allergy and atopic dermatitis

Tham¹,

Leung²,

Yamamoto‐Hanada³

et al. 2023

World Allergy Organization Journal

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A systematic review of quality and consistency of clinical practice guidelines on the primary prevention of food allergy and atopic dermatitis

Tham¹,

Leung²,

Yamamoto‐Hanada³

et al. 2023

World Allergy Organization Journal

View full text Add to dashboard Cite

“…In contrast, observational studies have found that early introduction (after the first days of life but within the first weeks of life) of cow's milk and continuation in the diet is associated with a lower chance of developing CMA [49,51,52], see Table 1. Thus, besides timing, the duration and frequency of allergen introduction during breastfeeding is of importance.…”

Section: Early Introduction Of Cow's Milk and Development Of Cow's Mi...mentioning

confidence: 95%

“…Thus, besides timing, the duration and frequency of allergen introduction during breastfeeding is of importance. The case-control study by Onizawa et al demonstrated that early introduction of formula based on cow's milk was associated with a decrease in the incidence of cow's milk allergy of 51 IgE-mediated-cow's-milk-allergic infants compared to 102 healthy controls [49]. There were significantly increased odds (aOR 23.4, 95%CI 5.39-104.52) of developing CMA when introduction was delayed (starting > 1 month after birth) or ingestion was irregular (less than once daily), further supporting the importance of duration and frequency.…”

Section: Early Introduction Of Cow's Milk and Development Of Cow's Mi...mentioning

confidence: 99%

See 1 more Smart Citation

Relevance of Early Introduction of Cow’s Milk Proteins for Prevention of Cow’s Milk Allergy

et al. 2022

View full text Add to dashboard Cite

Food allergy incidence has increased worldwide over the last 20 years. For prevention of food allergy, current guidelines do not recommend delaying the introduction of allergenic foods. Several groundbreaking studies, such as the Learning Early About Peanut Allergy study, showed that the relatively early introduction of this allergenic food between 4–6 months of age reduces the risk of peanut allergy. However, less is known about the introduction of cow’s milk, as many children already receive cow’s-milk-based formula much earlier in life. This can be regular cow’s milk formula with intact milk proteins or hydrolyzed formulas. Several recent studies have investigated the effects of early introduction of cow’s-milk-based formulas with intact milk proteins on the development of cow’s milk allergy while breastfeeding. These studies suggest that depending on the time of introduction and the duration of administration of cow’s milk, the risk of cow’s milk allergy can be reduced (early introduction) or increased (very early introduction followed by discontinuation). The aim of this narrative review is to summarize these studies and to discuss the impact of early introduction of intact cow’s milk protein - as well as hydrolyzed milk protein formulas - and the development of tolerance versus allergy towards cow’s milk proteins.

show abstract

Effect of Maternal Egg Intake During the Early Neonatal Period and Risk of Infant Egg Allergy at 12 Months Among Breastfeeding Mothers

et al. 2023

View full text Add to dashboard Cite

ImportanceEgg introduction in infants at age 4 to 6 months is associated with a lower risk of immunoglobulin E–mediated egg allergy (EA). However, whether their risk of EA at age 12 months is affected by maternal intake of eggs at birth is unknown.ObjectiveTo determine the effect of maternal egg intake during the early neonatal period (0-5 days) on the development of EA in breastfed infants at age 12 months.Design, Setting, and ParticipantsThis multicenter, single-blind (outcome data evaluators), randomized clinical trial was conducted from December 18, 2017, to May 31, 2021, at 10 medical facilities in Japan. Newborns with at least 1 of 2 parents having an allergic disease were included. Neonates whose mothers had EA or were unable to consume breast milk after the age of 2 days were excluded. Data were analyzed on an intention-to-treat basis.InterventionsNewborns were randomized (1:1) to a maternal egg consumption (MEC) group, wherein the mothers consumed 1 whole egg per day during the first 5 days of the neonate’s life, and a maternal egg elimination (MEE) group, wherein the mothers eliminated eggs from their diet during the same period.Main Outcomes and MeasuresThe primary outcome was EA at age 12 months. Egg allergy was defined as sensitization to egg white or ovomucoid plus a positive test result in an oral food challenge or an episode of obvious immediate symptoms after egg ingestion.ResultsOf the 380 newborns included (198 [52.1%] female), 367 (MEC: n = 183; MEE: n = 184) were followed up for 12 months. On days 3 and 4 after delivery, the proportions of neonates with ovalbumin and ovomucoid detection in breast milk were higher in the MEC group than in the MEE group (ovalbumin: 10.7% vs 2.0%; risk ratio [RR], 5.23; 95% CI, 1.56-17.56; ovomucoid: 11.3% vs 2.0%; RR, 5.55; 95% CI, 1.66-18.55). At age 12 months, the MEC and MEE groups did not differ significantly in EA (9.3% vs 7.6%; RR, 1.22; 95% CI, 0.62-2.40) or sensitization to egg white (62.8% vs 58.7%; RR, 1.07; 95% CI, 0.91-1.26). No adverse effects were reported.Conclusions and RelevanceIn this randomized clinical trial, EA development and sensitization to eggs were unaffected by MEC during the early neonatal period.Trial RegistrationUMIN Clinical Trials Registry: UMIN000027593

show abstract

Early Discontinuation of Cow's Milk Protein Ingestion Is Associated with the Development of Cow's Milk Allergy

Cited by 32 publications

References 14 publications

A systematic review of quality and consistency of clinical practice guidelines on the primary prevention of food allergy and atopic dermatitis

A systematic review of quality and consistency of clinical practice guidelines on the primary prevention of food allergy and atopic dermatitis

Relevance of Early Introduction of Cow’s Milk Proteins for Prevention of Cow’s Milk Allergy

Effect of Maternal Egg Intake During the Early Neonatal Period and Risk of Infant Egg Allergy at 12 Months Among Breastfeeding Mothers

Contact Info

Product

Resources

About