Early disease onset and increased risk of other autoimmune diseases in familial generalized vitiligo

LaBerge, Greggory S.; Mailloux, Christina M.; Gowan, Katherine; Holland, Paulene J.; Bennett, Dorothy C.; Fain, Pamela R.; Spritz, Richard A.

doi:10.1111/j.1600-0749.2005.00242.x

Cited by 180 publications

(186 citation statements)

References 35 publications

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“…3 Other studies showed rates of 24.1% 13 21% , 12 and 17%. 21 However, data from previous studies show low prevalence, such as the values reported in a Chinese study that showed an association of 1.36% , 0.6% in Nigeria, 2.6% in Colombia and 3% in a Romanian population.…”

Section: Discussionmentioning

confidence: 99%

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Perfil epidemiológico dos pacientes com vitiligo e sua associação com doenças da tireoide

Nunes

Esser

2011

An. Bras. Dermatol.

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BACKGROUND: Vitiligo is considered the most frequent acquired hypomelanosis. Although its pathogenesis is uncertain, it is believed that autoimmune etiology is the most plausible. This theory is based on the coexistence of vitiligo with autoimmune diseases. Objectives: To describe the epidemiological profile of vitiligo patients and to estimate the prevalence of the association of vitiligo with autoimmune thyroid diseases. Methods: A cross-sectional study was conducted through analysis of the medical records of patients diagnosed with vitiligo in the AME-UNISUL Outpatient Clinic of Dermatology and at HU-UFSC. The clinical and laboratorial characteristics of these patients were assessed. Results: 85 medical records were evaluated; 56 patients were female, with a mean age of 37.14 years and mean onset age of 25.25 years. Vitiligo vulgaris occurred in 70.6%. Autoimmune thyroid diseases were found in 22.4%. Other autoimmune diseases were identified in 5.9%. Patients with positive thyroid autoantibodies showed a probability of extension of vitiligo greater than 25%. There was no statistical difference with regard to the clinical characteristics of vitiligo in patients with or without autoimmune thyroiditis with hormonal change. Conclusion: The findings of this study are similar to those obtained by other authors, showing that autoimmune thyroid diseases are more common in patients with vitiligo. Keywords: Autoimmunity; Thyroid diseases; Vitiligo Resumo: FUNDAMENTO: O vitiligo é considerado a hipomelanose adquirida mais frequente. Apesar de sua etiopatogenia ser incerta, acredita-se que a etiologia autoimune seja a mais plausível, teoria que se fundamenta na concomitância de vitiligo com doenças autoimunes. OBJETIVOS: Traçar o perfil epidemiológico dos pacientes com vitiligo e estimar a prevalência da associação de vitiligo com doenças autoimunes da tireoide. MÉTODOS: Efetuou-se um estudo transversal, analisando-se prontuários dos pacientes com diagnóstico de vitiligo atendidos no Ambulatório de Dermatologia AME-Unisul e do HU-UFSC. Avaliaram-se as características clínicas e laboratoriais desses pacientes. RESULTADOS: Foram avaliados 85 prontuários, sendo 56 do sexo feminino, com idade média de 37,14 anos e idade média de início de 25,25 anos. O vitiligo vulgar ocorreu em 70,6% dos casos. As doenças autoimunes da tireoide foram encontradas em 22,4% dos casos. Outras doenças autoimunes foram identificadas em 5,9% dos casos. Os pacientes com anticorpos antitireoidianos positivos revelaram uma probabilidade elevada de extensão do vitiligo maior que 25%. Não houve diferença estatística quanto às características clínicas do vitiligo em portadores ou não de tireoidite autoimune com alteração hormonal. CONCLUSÃO: Os resultados deste estudo são similares aos de outros autores, mostrando que as doenças autoimunes da tireoide são mais frequentes nos pacientes com vitiligo.

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Section: Discussionmentioning

confidence: 99%

“…Increased frequency of type 1 diabetes mellitus and scleroderma was not found. 3,4,7,21 The presence of autoimmune hepatitis or parotiditis was not cited in the literature. The increased frequency of autoimmune diseases in patients with vitiligo suggests that all these conditions share a common etiologic factor.…”

Section: Discussionmentioning

confidence: 99%

Perfil epidemiológico dos pacientes com vitiligo e sua associação com doenças da tireoide

Nunes

Esser

2011

An. Bras. Dermatol.

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“…27 Dave et al showed antibody positivity (anti-Tg, anti-TPO) in 31.4% of their cases in India against 10% of their controls. 15 In our study the anti TPO antibody positivity was more common in women in both the vitiligo and the control groups, though not statistically significant. A higher prevalence was also seen in other studies.…”

Section: Discussionmentioning

confidence: 71%

“…12,15 Autoimmune thyroid diseases often present with initial transient hyperthyroidism which may be missed and later progress to subclinical or overt hypothyroidism. Often, there is a delay in seeking medical advice and thyroid evaluation in our population which may explain the higher prevalence of hypothyroidism in our study.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of thyroid dysfunction and anti-thyroid peroxidase antibodies in vitiligo patients

Jishna¹,

Binitha²,

Latheef³

et al. 2017

Int J Res Dermatol

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Background: Vitiligo is associated with various autoimmune diseases, including autoimmune thyroid disease. The objectives of the present study was to determine the prevalence of thyroid dysfunction and anti-thyroid peroxidase antibodies in patients with vitiligo, and to compare the clinical profile of anti-thyroid peroxidase positive and anti-thyroid peroxidase negative patients.Methods: A cross-sectional comparative study was conducted in 100 patients with vitiligo and 100 controls. After dermatologic and systemic evaluation, serum thyroid hormones and anti-thyroid peroxidase antibody levels were measured in all the subjects.Results: Thyroid dysfunction was more common in the vitiligo group (27%) than in the controls. Serum thyroid stimulating hormone abnormalities were more common in the vitiligo group (27%) than in the controls (6%). The most common thyroid dysfunction was subclinical hypothyroidism. Anti-thyroid peroxidase antibody positivity was higher in the vitiligo group (36%) when compared to the controls (24%), and the most common type of vitiligo was vitiligo vulgaris (18%) in this group. Thyroid dysfunction and anti-thyroid peroxidase positivity were more common in women (58%) when compared to men (42%). There was a significantly higher prevalence of other autoimmune diseases in the vitiligo group (20%) compared to the controls (6%). Conclusions: This study shows a significant association between vitiligo and thyroid dysfunction, anti-thyroid peroxidase antibodies and other autoimmune diseases. We recommend that thyroid evaluation and regular follow-up should be done in patients with vitiligo for prompt detection of thyroid dysfunction.

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“…[2] First degree relatives have increased frequency of the same autoimmune diseases. [3] Its heritable constitutional predilection has found to be 20 to 30 %. 4 Polygenic multifactorial susceptibility that is triggered by environmental factors has been implicated in initiation of the disease.…”

Section: Introductionmentioning

confidence: 99%

A Clinical Study of Vitiligo and Associated Autoimmune Disorders - A Retrospective Study

Vijayalakshmi¹,

Maheshwari²,

Dhanalakshmi³

et al. 2017

AIMDR

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Background: Vitiligo is an autoimmune disorder characterized by de-pigmentation affecting 1% of the population Vitiligo is associated with a lot of other autoimmune disorders. Aim of the study was to determine the prevalence of other co-morbid autoimmune disorders in vitiligo patients in our Institution. Methods: A total of 100 patients with vitiligo who attended our Hospital vitiligo clinic were included. Patients with lesion which were less than 1cm in size and inactive vitiligo were excluded from the study. The co-morbid autoimmune disorders were collected and analyzed. Results: In our study group of 100 patients with vitiligo, 30 patients had autoimmune disorders. Out of the 30 patients, 20 patients had Diabetes Mellitus and it was found out to be the most common autoimmune disorder. Among the rest of 10 patients, 5 patients had pernicious anemia, 2 patients had alopecia areata, 2 patients had psoriasis vulgaris and 1 patient had linear morphea. Conclusion: Most of the patients with vitiligo have one or more autoimmune disorder which supports the autoimmune theory of vitiligo. It therefore mandatory to screen all patients of vitiligo for autoimmune disorders.

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Early disease onset and increased risk of other autoimmune diseases in familial generalized vitiligo

Cited by 180 publications

References 35 publications

Perfil epidemiológico dos pacientes com vitiligo e sua associação com doenças da tireoide

Perfil epidemiológico dos pacientes com vitiligo e sua associação com doenças da tireoide

Prevalence of thyroid dysfunction and anti-thyroid peroxidase antibodies in vitiligo patients

A Clinical Study of Vitiligo and Associated Autoimmune Disorders - A Retrospective Study

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