Early electrical and geometric changes after percutaneous closure of large atrial septal defect

Atrial myocardial pathoelectrophysiology in adults with a secundum atrial septal defect is unaffected by closure of the defect. A study using high resolution signal-averaged orthogonal P-wave technique

“…The changes of heart chamber sizes after ASD closure in our material are consistent with what has been earlier reported [20,21]. An important finding in the present study is the absence of a mechano-electrical interaction as relationships between P-wave duration and atrial sizes were lacking and moreover, that the marked reduction of right atrial size following ASD closure was not accompanied by a change in P-wave duration.…”

Closure of atrial septal defect in the adult. Cardiac remodeling is an early event

“…This is not controversial. Similar findings have been reported in adult as well as pediatric series on atrial septal defect 12-32 months after closure [3][4][5][6][7][8]. However, there is a subgroup of patients, even in pediatric series, in whom right atrial or ventricular size does not become normal.…”

Impact of transcatheter closure of atrial septal defects on cardiac function

“…However, the shunt ratio in the current study was about 50%, which could lead to a different conclusion. Several studies reported that LV end-diastolic volume on MRI and LVDd on two-dimensional echocardiography increased during the early follow-up phase, as observed in the current study [16,17]. Although the precise mechanism of the rapid LV volume change was unclear, a sudden relief of right ventricular volume overload after ASD closure decreasing the RV dimension may improve LV oppression and LV deformity [15,17].…”