Early embryonic death in mares: clinical and hormonal aspects

Papa, Frederico Ozanam; Lopes, Maria Denise; Alvarenga, Marco Antônio; Meira, Cezinande de; Luvizotto, Maria Cecília Rui; Langoni, Hélio; Ribeiro, Erley Felix; Azedo, Antonio Esteves; Bomfim, Antonio Carlos de Miranda

doi:10.1590/s1413-95961998000400005

Cited by 15 publications

(28 citation statements)

References 3 publications

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“…2000). The recent results published by Papa et al. (1998) indicate no correlation in P4 levels between mares with and without EED.…”

Section: Introductionmentioning

confidence: 80%

“…Early embryonic death in mares may be caused by various internal (embryo-and mother-related) and external factors. The former include poor quality of oocytes, embryonic defects, lack of maternal recognition of gestation, unfavourable conditions in the uterine tubes and uterus, endometriosis, endometritis and corpus luteum (CL) insufficiency (Darenius et al 1988;Ball et al 1989;Allen 1992;Gandolfi et al 1992;Wathes 1992;Papa et al 1998;Scharp 2000;Vanroose et al 2000). The main predisposing external factors include age of mares, mating management, stress and improper nutrition.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, endocrine disturbances are relevant, e.g. insufficient production of progesterone (P4) resulting from CL failure (Zavy et al 1984;Papa et al 1998;Allen 2001). The suppressive effect of P4 on the Th1 cell immune response and enhancement of the Th2 response is one of the mechanisms responsible for maintenance and development of pregnancy (Robertson et al 1994;Raghupathy 1997;Piccinni et al 2000).…”

Section: Introductionmentioning

confidence: 99%

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Serum Levels of Acute Phase Proteins: SAA, Hp and Progesterone (P4) in Mares with Early Embryonic Death

Krakowski

Krawczyk²,

Kostro

et al. 2011

Reprod Domestic Animals

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The study involved 46 healthy purebred Arabian mares exhibiting regular oestrous cycles that underwent artificial insemination (AI). Pregnancy was detected ultrasonographically (US) in 40 mares. In 15 mares in foal, early embryonic death (EED) was observed during the pregnancy days 14-21. Blood for determinations of serum acute phase proteins (SAA and Hp) and progesterone (P4) was sampled 12-24 h before ovulation and the first insemination, at 12, 24, 72, 96 h and on day 7, 10, 14, 21, 35 and 55 after ovulation. The results revealed that in 25 mares without EED, the serum levels of P4, SAA and Hp were within physiological limits; in 15 mares with EED, the levels of SAA and Hp were significantly increased. In seven mares with EED, high levels of SAA and Hp were already found before ovulation and at 12, 24, 72, 96 h as well as on day 7 and 10 post-ovulation, whereas the level of P4 was normal for early pregnancy. In the remaining eight mares with EED, increased levels of SAA and Hp were found at 72 h after ovulation and maintained until day 55. In this group, the level of P4 decreased since 96 h after ovulation. Determinations of SAA, Hp and P4 in mares in early pregnancy (EP) are useful for monitoring normal development of pregnancy and for diagnosis of subclinical genital inflammations, which may lead to EED.

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“…2000). The recent results published by Papa et al. (1998) indicate no correlation in P4 levels between mares with and without EED.…”

Section: Introductionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serum Levels of Acute Phase Proteins: SAA, Hp and Progesterone (P4) in Mares with Early Embryonic Death

Krakowski

Krawczyk²,

Kostro

et al. 2011

Reprod Domestic Animals

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“…Quanto à avaliação histopatológica, Papa et al (1998) observaram que 100% das éguas com histórico de subfertilidade apresentaram evidências histopatológicas endometriais. Já Ricketts (1975a) encontrou em 93,3% das éguas e Ricketts (1975b) e Doig et al (1981) em 90%.…”

Section: Discus Discus Discus Discus Discussão São São São Sãounclassified

“…Assim, pressupõe-se a importância do endométrio estar isento de anormalidades para a manutenção da gestação (Kenney 1978). No presente estudo, assim como Doig et al (1981) e Papa et al (1998), os achados mais freqüentes foram fibrose e endometrite aguda e/ou crônica. Todas as éguas sem histórico de subfertilidade que foram colocadas neste grupo, neste experimento, mesmo não tendo sido escolhidas em função da idade, eram jovens, a média de idade foi de 7 anos, formando então um grupo de éguas sadias com bom histórico reprodutivo.…”

Section: Discus Discus Discus Discus Discussão São São São Sãounclassified

Estudo comparativo de éguas repetidoras ou não de cio através da avaliação histológica do endométrio e das concentrações plasmáticas de progesterona

Eigenheer-Moreira

Fernandes²,

Queiroz³

et al. 2007

Pesq. Vet. Bras.

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Comparative study of repeat breeds and healthy mares through endometrial Comparative study of repeat breeds and healthy mares through endometrial Comparative study of repeat breeds and healthy mares through endometrial Comparative study of repeat breeds and healthy mares through endometrial Comparative study of repeat breeds and healthy mares through endometrial histology and plasmatic progesterone concentrations histology and plasmatic progesterone concentrations histology and plasmatic progesterone concentrations histology and plasmatic progesterone concentrations histology and plasmatic progesterone concentrations.] Estudo comparativo de éguas repetidoras ou não de cio através da avaliação histológica do endométrio e das concentrações plasmáticas de progesterona. Pesquisa Veterinária Brasileira 27 (12) The study aimed to compare endometrial histology and plasmatic progesterone (P4) concentration of repeat breeds and healthy mares. The hypothesis was that there is a correlation between infertility and endometrial histology and P4 concentration in both groups. A total of 36 Campolina and Mangalarga Marchador mares in reproductive age (3-23 years) were used, 11 of them were healthy mares (Control group, 7 embryo recipient and 4 embryo donors), and 25 repeat breeders (10 embryo recipient and 15 embryo donors), classified as based on their reproductive history. Endometrial and blood samples were collected for respectively histological and plasma progesterone concentration evaluation. The endometrial samples obtained after biopsy were fixed in Bouin's fluid, processed, included in paraffin, and stained with HematoxylinEosin (HE) for histopathological examination. Plasmatic progesterone concentrations were evaluated by enzyme immunoessay (ELISA). There was no correlation between progesterone concentration and fertility. But there was a positive correlation between age and fertility, as older mares had major tendency of subfertility than younger ones. There was also a correlation between biopsy categories and fertility, as more histological alterations were found, higher were the chances for the mares to be subfertile. However not all mares classified as Category I and II maintained pregnancy until parturition. Other factors could influence pregnancy maintenance. In the same way, not all mares in Category III were infertile. The endometrial biopsy was shown to be an easy and cheap diagnostic technique with minimal discomfort to the animals and, together with other data, to be a very important component in the investigation of mare fertility.

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Treatment with human chorionic gonadotrophin before ovulation increases progestin concentration in early equine pregnancies

Köhne¹,

Kuhl

Ille

et al. 2014

Animal Reproduction Science

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Early embryonic death in mares: clinical and hormonal aspects

Cited by 15 publications

References 3 publications

Serum Levels of Acute Phase Proteins: SAA, Hp and Progesterone (P4) in Mares with Early Embryonic Death

Serum Levels of Acute Phase Proteins: SAA, Hp and Progesterone (P4) in Mares with Early Embryonic Death

Estudo comparativo de éguas repetidoras ou não de cio através da avaliação histológica do endométrio e das concentrações plasmáticas de progesterona

Treatment with human chorionic gonadotrophin before ovulation increases progestin concentration in early equine pregnancies

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