2016
DOI: 10.1002/jhbp.358
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Early enteral nutrition improves intestinal immune barrier in a rat model of severe acute pancreatitis

Abstract: Early enteral nutrition improves intestinal immune barrier, thus reducing bacterial and endotoxin translocation and improving the survival rate in SAP rats.

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Cited by 16 publications
(13 citation statements)
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“…These metabolic abnormalities, in conjunction with failure to receive timely treatment, may lead to multiple organ failure (MOF) involving the heart, lungs, and kidneys. This further worsens the prognosis and overall survival rate of patients with SAP [ 4 , 5 ]. Therefore, nutritional support is very important as a therapeutic measure for patients with SAP.…”
Section: Introductionmentioning
confidence: 99%
“…These metabolic abnormalities, in conjunction with failure to receive timely treatment, may lead to multiple organ failure (MOF) involving the heart, lungs, and kidneys. This further worsens the prognosis and overall survival rate of patients with SAP [ 4 , 5 ]. Therefore, nutritional support is very important as a therapeutic measure for patients with SAP.…”
Section: Introductionmentioning
confidence: 99%
“…In addition, there are pancreatic subcapsular injection, L-arginine injection, cerulein injection, and bile-free ethionine feeding approaches. 31 Metabolomics tools play an important role in researching metabolic disorders and metabolism-related diseases, [32][33][34][35] in the discovery and identication of biomarkers [36][37][38][39] and in investigating responses to treatment. [40][41][42][43][44][45][46][47][48] A signicant increase in serum amylase for 12 hours in the rats, revealed by serological examination, demonstrated that serum amylase is strongly activated.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, early EN has been recognized as one of the most important treatments for AP, especially SAP [ 1 ]. Early EN has been proven to be related to suppression of negative nitrogen balance in the acute inflammation phase, the promoted restoration of the intestinal barrier function, and the decreased occurrence of enterogenous infection [ 41 , 42 ]. Furthermore, decreased gastric motility can also lead to the development of EN intolerance, causing delayed or failed EN [ 8 ].…”
Section: Discussionmentioning
confidence: 99%