Early Esophageal Adenocarcinoma with Non-Barrett's Columnar Epithelium Origin: Two Case Reports and a Literature Review

Abstract

We herein report two cases of early esophageal adenocarcinoma derived from non-Barrett's columnar epithelium. Both patients, a 65-year-old woman and 60-year-old man, had elevated lesions on white-light imaging. Magnifying endoscopy revealed slightly irregular surface and vessel patterns, and both patients were successfully treated with endoscopic submucosal dissection. Histopathologically, both lesions comprised of welldifferentiated gastric mucin phenotype adenocarcinoma. One lesion was accompanied by ectopic gastric mucosa, but the other was speculated to be ectopic gastric mucosa according to the tumor locus at the upper thoracic esophagus. Despite its rarity, endoscopists should consider the existence of adenocarcinoma derived from non-Barrett's columnar epithelium.

Multidisciplinary treatment of advanced cervical esophageal adenocarcinoma derived from a gastric inlet patch: A case report

“…Several case reports of EAC derived from ectopic gastric mucosa have been reported (17)(18)(19)(20)(21)(22)(23). Kitasaki et al (17) reported a case of repeated local recurrence at the same site despite multiple radical endoscopic resections.…”

“…These results suggested that EAC in the cervical or upper thoracic esophagus, rich in lymphatic chains and vascular networks, may be difficult to treat and have a poor prognosis (23). The basic treatment strategy for EAC is local control through resection, and some reports have shown that endoscopic resection can be expected to treat cervical esophageal lesions in early-stage cancers (19)(20)(21)(22). Tanaka et al (22) reported a case in which complete resection was achieved with larynx-preserving surgery, indicating that larynx-preserving surgery is possible for localized lesions that do not extend to the hypopharynx as long as negative margins are ensured.…”