Early Excision and Application of Matriderm with Simultaneous Autologous Skin Grafting in Facial Burns

Atherton, Duncan; Tang, Raymond; Jones, Isabel; Jawad, Mohammad

doi:10.1097/prs.0b013e3181c725e5

Cited by 46 publications

(28 citation statements)

References 4 publications

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“…Integra is also available without the external silicone layer, as single‐layer dermal substitute, together with Alloderm (LifeCell Corporation, Branchburg, New Jersey), Matriderm (MedSkin Solutions DR. Suwelack AG, Billerbeck, Germany) and ReCell (Avita Medical, Cambridge, UK) …”

Section: Discussionmentioning

confidence: 99%

Skin cancers and dermal substitutes: Is it safe? Review of the literature and presentation of a 2‐stage surgical protocol for the treatment of non‐melanoma skin cancers of the head in fragile patients

Marcasciano

Mazzocchi

Kaciulyte

et al. 2018

International Wound Journal

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Non-melanoma skin cancers (NMSC) represent the most common skin tumours of the head region. We describe the use of dermal substitute in a 2-stage surgery protocol for selected fragile patients to remove NMSC of the head region. A review of the literature focusing on dermal substitutes' safety after skin tumours excision is provided. A total of 45 fragile patients with NMSC in the head region were selected and scheduled for the 2-stage surgical protocol. The first stage consisted of traditional surgical excision and immediate coverage with Hyalomatrix (Fidia Advanced Biopolymers, Abano Terme, Italy). After histology confirmed diagnosis and clearance of the margins, full-thickness skin autografts were performed. All of the patients reached complete tumour excision and wound healing. No local recurrences were registered during 24 months follow up. The 2-stage surgical therapeutic-diagnostic-reconstructive approach represents a less stressful and oncologically safe surgical protocol in selected fragile patients. When patients cannot tolerate invasive and long surgical procedures, general anaesthesia, and long hospitalisation, skin grafting following temporary skin substitute coverage can achieve oncological clearance and provide good functional and aesthetic results. The use of dermal substitutes represents a valid alternative surgical option in cases of ASA III, fragile patients non-eligible for complex reconstructive surgery. To our knowledge, this is the first paper reviewing literature focusing on dermal substitutes' applications and safety after skin tumour excision.

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Section: Discussionmentioning

confidence: 99%

Skin cancers and dermal substitutes: Is it safe? Review of the literature and presentation of a 2‐stage surgical protocol for the treatment of non‐melanoma skin cancers of the head in fragile patients

Marcasciano

Mazzocchi

Kaciulyte

et al. 2018

International Wound Journal

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“…24 However, its thickness is thin, only 1 mm; thus, it should be covered with split thickness skin grafts, causing morbidity of the donor site. [25][26][27][28][29] Furthermore, there are risks of allergic reaction and infection caused by bovine collagen. To overcome these challenges, alternative artificial scaffolds based on poly(ethylene glycol), poly(lactic acid), polycaprolactone, polyphosphates, ceramics and metals have been developed.…”

Section: Discussionmentioning

confidence: 99%

Development of Artificial Dermis Using 3D Electrospun Silk Fibroin Nanofiber Matrix

Oj¹,

Hw²,

Kim³

et al. 2014

Journal of Biomedical Nanotechnology

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Several auto- or alloplastic dermal substitutes have been used for full thickness skin defects. However, there is no ideal dermal substitute that is biocompatible and offers adequate mechanical properties and sufficient thickness and volume. Silk fibroin can be considered a possible alternative material for the construction of dermal substitutes. Nanofibers fabricated by electrospinning silk fibroin were considered an excellent candidate due to their desirable biocompatibility. However, it is generally difficult for cells to infiltrate the electrospun silk fibroin due to its small pore size. To overcome this challenge, a key parameter is the control of the pore size of silk fibroin electrospun such that cells can easily infiltrate into the nanofibers and proliferate internally. In this work, a novel approach is introduced by dropping two different size NaCl crystals above the rotating collector, which become incorporated into the nanofibers. The structures and properties of the, resulting electrospun silk fibroin were characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and its wound healing effect for a full thickness skin defect was compared with Matriderm. Although the dermal regenerative effect of the 3D-SF (3D electrospun silk fibroin nanofiber matrix) was similar to that of Matriderm, the 3D-SF was almost completely degraded and did not induce wound contracture like Matriderm. We suggest that 3D-SF can be applied to the treatment of full thickness skin defects.

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“…• there has been no systemic investigation of these dermal substitutes in head-to-head studies Collagen-elastin matrix has been used successfully to cover burn wounds combined with mesh-graft transplantation or split-skin transplantation without meshing as a onestep procedure (11)(12)(13)(14)(15)(16). Another indication for the dermal matrix substitute is the closure of traumatic defects or defects after tumour surgery with exposed tendons (17,18).…”

Section: Key Pointsmentioning

confidence: 99%

Use of a collagen–elastin matrix for hard to treat soft tissue defects

Wollina

Meseg

Weber

2011

International Wound Journal

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As deep soft tissue defects with exposed bone, cartilage or tendons are not suitable for wound closure with skin mesh grafts, other techniques are needed. We report on six patients, one female and five males, aged between 32 and 89 years, and deep soft tissue defects with exposed tendons, cartilage or bone. The aetiology of these defects was vascular (n = 3), tumour surgery (2), and post-traumatic (1). Wounds were treated with a collagen-elastin matrix applied above the exposed structures. In five patients, the procedure was combined with mesh graft transplantation in the same setting. Follow-up varied between 12 and 40 weeks. Wound healing was uncomplicated in all transplanted patients until first dressing change after 7 days. All but one transplant showed a 100% take rate and the transplant was stable within 10-14 days. A complete wound closure was also achieved without transplantation, but this took 8 weeks. No adverse effects were noted. There was no skin contracture of the skin grafts. Collagen-elastin matrix with split-thickness skin grafts is a useful tool in deep soft tissue. The time to heal can be reduced.

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Early Excision and Application of Matriderm with Simultaneous Autologous Skin Grafting in Facial Burns

Cited by 46 publications

References 4 publications

Skin cancers and dermal substitutes: Is it safe? Review of the literature and presentation of a 2‐stage surgical protocol for the treatment of non‐melanoma skin cancers of the head in fragile patients

Skin cancers and dermal substitutes: Is it safe? Review of the literature and presentation of a 2‐stage surgical protocol for the treatment of non‐melanoma skin cancers of the head in fragile patients

Development of Artificial Dermis Using 3D Electrospun Silk Fibroin Nanofiber Matrix

Use of a collagen–elastin matrix for hard to treat soft tissue defects

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