Early Factors Associated With Fluid Sequestration and Outcomes of Patients With Acute Pancreatitis

de-Madaria, Enriqué; Banks, Peter A.; Moya-Hoyo, Neftalí; Wu, Bechien U.; Rey-Riveiro, Mónica; Acevedo-Piedra, Nelly G.; Martínez, Juan; Lluı́s, Fèlix; Sánchez‐Paya, José; Singh, Vikesh K.

doi:10.1016/j.cgh.2013.10.017

Cited by 63 publications

(64 citation statements)

References 43 publications

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Section: Fluid Therapy (Ft)mentioning

confidence: 98%

“…Five variables independently predicted fluid sequestration: younger age, alcohol etiology, hematocrit, glucose and SIRS [92]. Median fluid sequestration was 3.2 L and increasing volumes associated with longer hospital LOS and higher rates of acute fluid collection, pancreatic necrosis and POF [92]. Fluid sequestration had no significant association with mortality, but according to others, fluid sequestration associates with intra-abdominal hypertension (IAH) [93] and progression to abdominal compartment syndrome (ACS), which increases mortality and hospital/ICU utilization for patients with AP [94].…”

Section: Fluid Therapy (Ft)mentioning

confidence: 99%

“…To model harm from aggressive FT, de-Madaria [92] retrospectively examined risk factors and outcome of developing fluid sequestration during the first 48 h after hospital admission. Five variables independently predicted fluid sequestration: younger age, alcohol etiology, hematocrit, glucose and SIRS [92].…”

Section: Fluid Therapy (Ft)mentioning

confidence: 99%

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Clinical update on fluid therapy and nutritional support in acute pancreatitis

DiMagno

2015

Pancreatology

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Section: Fluid Therapy (Ft)mentioning

confidence: 98%

Section: Fluid Therapy (Ft)mentioning

confidence: 99%

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Clinical update on fluid therapy and nutritional support in acute pancreatitis

DiMagno

2015

Pancreatology

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“…However, the evidence basis for fluid therapy in AP is relatively weak. Patients with mild AP usually have lower levels of fluid sequestration and thus lower fluid resuscitation requirements than patients with moderate or severe AP [47]. This is mainly due to the higher occurrence of serious complications of severe AP such as formation of fluid collections, necrosis, or multiorgan failure.…”

Section: Early Conservative Treatment Of Apmentioning

confidence: 99%

Risk Stratification and Early Conservative Treatment of Acute Pancreatitis

2019

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Background: Acute pancreatitis (AP) is a potentially life-threatening common gastrointestinal disorder with increasing incidence around the globe. Although the majority of cases will take an uneventful, mild course, a fraction of patients is at risk of moderately severe or severe pancreatitis which is burdened with substantial morbidity and mortality. Early identification of patients at risk of a severe disease course and an adopted treatment strategy are crucial to avoid adverse outcomes. Summary: In this review we summarize the most recent concepts of severity grading in patients diagnosed with AP by adopting recommendations of current guidelines and discussing them in the context of the available literature. The severity of AP depends on the presence of local and/or systemic complications and organ failure. To predict the severity early in the disease course, host-specific factors (age, comorbidities, body mass index), clinical risk factors (biochemical and physiological parameters and scoring systems), as well as the response to initial therapy need to be considered and revisited in the short term. Depending on the individual risk and comorbidity the initial treatment can be guided, which will be discussed in the second part of this review. Key Message: Predicting the severity of AP and adapting the individual treatment strategy requires multidimensional risk assessment and close observation during the early phase of AP development.

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“…An observational study including 403 patients from two prospectively collected cohorts showed an association between early fluid deficit and the development of pancreatic fluid collections, pancreatic necrosis, persistent organ failure and the length of hospital stay (13). In a smaller cohort Scottish patients who died from acute pancreatitis received significantly less fluids within 48 h after admission than survivors (16).…”

Section: Estimation Of Fluid Requirementmentioning

confidence: 99%