“…After 24 h of phototherapy, the percentage of Z,E-bilirubin to total bilirubin isomers was higher for infants treated with light centered at 459 nm than for those treated with light centered at 497 nm (23% vs. 14%), and thus also the percentage of total bilirubin isomers formed during treatment to total bilirubin isomers was highest for the infants treated with light centered at 459 nm (26% vs. 18%) ( Table 3). This is in agreement with previous in vitro studies, which showed that after equilibrium between Z,Z-and Z,Eisomers is reached, the percentage of Z,E-bilirubin decreases with longer wavelengths (4,16).This observation has also been confirmed in earlier clinical studies, where the reported percentages of Z,E-bilirubin to total bilirubin isomers were: 24% to 27% (10,13,14), 16% (10) and 9% (14) in children exposed to light of wavelengths ~460, 490, and 528 nm, respectively.…”