Early functional differentiation of heart muscle cells

Meda, E; Ferroni, A

doi:10.1007/bf02157695

Cited by 28 publications

(12 citation statements)

References 4 publications

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“…The similarities between the early atrioventricular canal myocardium in the embryo and the atrioventricular node and atrioventricular ring bundle in the formed heart were noticed: compared to adjacent atrial cells, atrioventricular cells have a high glycogen content, a poorly developed sarcoplasmatic reticulum and myofilaments, and few junctional complexes (Virágh and Challice, 1977a;Virágh and Challice, 1977b). Consistently, several important functional properties of the embryonic atrioventricular myocardium, including automaticity and slow conduction (Meda and Ferroni, 1959;DeHaan, 1965;Lieberman and Paes de Carvalho, 1965;Tallini et al, 2006), were also found to be maintained in the corresponding region of the formed heart. Indeed, careful examination of serial sections of consecutive stages suggested that the atrioventricular node was derived from the atrioventricular canal (Wenink, 1976;Virágh and Challice, 1983).…”

Section: Origin and Fate Of The Atrioventricular Canal Myocardiummentioning

confidence: 52%

Origin and development of the atrioventricular myocardial lineage: Insight into the development of accessory pathways

Aanhaanen

Moorman

Christoffels

2011

Birth Defects Research

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Defects originating from the atrioventricular canal region are part of a wide spectrum of congenital cardiovascular malformations that frequently affect newborns. These defects include partial or complete atrioventricular septal defects, atrioventricular valve defects, and arrhythmias, such as atrioventricular re-entry tachycardia, atrioventricular nodal block, and ventricular preexcitation. Insight into the cellular origin of the atrioventricular canal myocardium and the molecular mechanisms that control its development will aid in the understanding of the etiology of the atrioventricular defects. This review discusses current knowledge concerning the origin and fate of the atrioventricular canal myocardium, the molecular mechanisms that determine its specification and differentiation, and its role in the development of certain malformations such as those that underlie ventricular preexcitation.

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Section: Origin and Fate Of The Atrioventricular Canal Myocardiummentioning

confidence: 52%

Origin and development of the atrioventricular myocardial lineage: Insight into the development of accessory pathways

Aanhaanen

Moorman

Christoffels

2011

Birth Defects Research

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“…Utilizing a micro-electrode method, Meda & Ferroni (1959) observed a pace-maker type action potential in the sinus region of the heart of embryonic chick as 13 somites (42 hr The results shown in Fig. 3 indicate that the spatial localization of the pace-maker type action potential has begun by the 9 somite developmental stage, corresponding to around 30 hr.…”

Section: Discussionmentioning

confidence: 99%

“…Thus the earliest stage at which pace-maker type S. FUJI], A. HIROTA AND K. KAMINO action potentials had been demonstrated, using micro-electrode, was in the 13 somite embryonic chick heart (Meda & Ferroni, 1959;Van Mierop, 1967).…”

Section: Introductionmentioning

confidence: 99%

Optical indications of pace‐maker potential and rhythm generation in early embryonic chick heart.

Fujii¹,

Hirota²,

Kamino³

1981

The Journal of Physiology

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SUMMARY1. Pace-maker type action potentials and rhythm generation in very early embryonic chick hearts have been monitored using a voltage-sensitive merocyaninerhodanine dye.2. Rhythmicity in recurrence of the spontaneous action potentials was evident at the 7 somite developmental stage, and the rhythm was completely organized by the early period of the 9 somite stage; just before the first contraction. The rhythmic recurrence of action potentials was increased in frequency as development proceeded from the 7 to the 9 somite stage, and presumably gives rise to the rhythm of the initial contractions.3. Optical signals resembling the pace-maker type action potential with a diastolic depolarization phase were first detected in embryonic hearts at the 8 somite stage. At this stage, pace-maker type action potentials were detected from various regions, such as the ventricle and the unfused primordia at the atrium level.4. Regionalization of pace-maker type action signals was exhibited at the early period of the 9 somite stage. At this stage, the pace-maker type signals were often evident at the atrium level, while the cardiac type signals were detected in the ventricular region.5. Hence it is concluded (i) that the rhythmicity has already been generated at the 7 somite developmental stage, (ii) that the pace-making cells are widely distributed in the embryonic hearts at the 7-8 somite stages and (iii) that the appearance of the pace-maker potential is initially localized to the atrium level at about the 9-10 somite stages.

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“…15,16 The early development of conduction in the heart has been studied mainly in avian embryos. 16,17 When 7 to 10 somites have developed (equivalent age of a human embryo of Ϸ20 days), a single pacemaking area becomes established at the IFT of the heart.…”

Section: Development Of Polaritymentioning

confidence: 99%

Development of the Cardiac Conduction System

2003

Novartis Foundation Symposia

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Early functional differentiation of heart muscle cells

Cited by 28 publications

References 4 publications

Origin and development of the atrioventricular myocardial lineage: Insight into the development of accessory pathways

Origin and development of the atrioventricular myocardial lineage: Insight into the development of accessory pathways

Optical indications of pace‐maker potential and rhythm generation in early embryonic chick heart.

Development of the Cardiac Conduction System

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