Early Gastric Cancer: Current Advances of Endoscopic Diagnosis and Treatment

Zhu, Linlin; Qin, Jinyu; Wang, Jin; Guo, Tianjiao; Wang, Zijing

doi:10.1155/2016/9638041

Cited by 30 publications

(25 citation statements)

References 65 publications

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“…With advances in diagnostic techniques, the rates of detecting early-stage gastric cancer (EGC), defined by the depth of the neoplastic invasion being restricted to the submucosal layer of the stomach, irrespective of lymph node (LN) metastasis, has increased to almost 20% in some countries (1,2). Although early diagnosis affords the opportunity for minimally invasive treatment such as endoscopic resection, this procedure remains only potentially curative as a frontline and unimodal therapy in a subset of EGC patients (1)(2)(3). Furthermore, the current rudimentary classification system of EGC does not quantitatively phenotype patient tumors at the molecular level, and overlooks any degree of metastatic potential, thus raising concerns that therapeutic endoscopy may still yield incorrect prognoses in some patients.…”

Section: Introductionmentioning

confidence: 99%

Clinical Utility of a STAT3-Regulated miRNA-200 Family Signature with Prognostic Potential in Early Gastric Cancer

Gao

et al. 2018

Clinical Cancer Research

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The majority of gastric cancer patients are diagnosed with late-stage disease, for which distinct molecular subtypes have been identified that are potentially amenable to targeted therapies. However, there exists no molecular classification system with prognostic power for early-stage gastric cancer (EGC) because the molecular events promoting gastric cancer initiation remain ill-defined. miRNA microarrays were performed on gastric tissue from the preclinical EGC mouse model, prior to tumor initiation. Computation prediction algorithms were performed on multiple data sets and independent gastric cancer patient cohorts. Quantitative real-time PCR expression profiling was undertaken in-based mouse strains and human gastric cancer cells genetically engineered for suppressed activation of the oncogenic latent transcription factor STAT3. Human gastric cancer cells with modulated expression of the miR-200 family member miR-429 were also assessed for their proliferative response. Increased expression of miR-200 family members is associated with both tumor initiation in a STAT3-dependent manner in mice and EGC (i.e., stage IA) in patient cohorts. Overexpression of miR-429 also elicited contrasting pro- and antiproliferative responses in human gastric cancer cells depending on their cellular histologic subtype. We also identified a miR-200 family-regulated 15-gene signature that integrates multiple key current indicators of EGC, namely tumor invasion depth, differentiation, histology, and stage, and provides superior predictive power for overall survival compared with each EGC indicator alone. Collectively, our discovery of a STAT3-regulated, miR-200 family-associated gene signature specific for EGC, with predictive power, provides a molecular rationale to classify and stratify EGC patients for endoscopic treatment. .

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Section: Introductionmentioning

confidence: 99%

Clinical Utility of a STAT3-Regulated miRNA-200 Family Signature with Prognostic Potential in Early Gastric Cancer

Gao

et al. 2018

Clinical Cancer Research

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“…Endoscopic ultrasound is available only in select centres. 7 Ultrasonography (USG) and Multidetector Computed Tomography (CT) with Multiplanar Reformation (MPR) gives both physiological as well as anatomical description of the site and extension of lesion within the lumen, as well as beyond the lumen. 4,5 The other modalities which are used are Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET).…”

Section: Discussionmentioning

confidence: 99%

Comparative Study of Transabdominal Ultrasonography and Multidetector Row Computed Tomography in Preoperative Staging of Gastric Carcinoma

M.P¹,

Narayanaswamy²,

H.V³

2018

IJCMSR

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Gastric cancer is one of the most common malignant tumours in the digestive tract and is the second most common cause of cancer-related death worldwide. The incidence in India is 7-8 cases per 100,000 persons per year and it is the most common cancer in males in Chennai. The aim of the present study was to compare Ultrasonography (USG) and MDCT findings in the detection and staging of gastric carcinoma by correlating with histopathology. Material and methods: Data were collected from 30 cases of clinically suspected/proven cases of gastric carcinoma that were referred to the Department of Radiodiagnosis for Ultrasonography and MDCT. Ultrasound examination was performed using a real time ultrasound with curvilinear transducer of 2-5 MHz and linear transducer of 7-10 MHz with ingestion of boiled cooled water. Plain and contrast MDCT study was performed in all the cases. The comparative study of ultrasonography and MDCT in diagnosing and staging of gastric carcinoma were analysed. Results: The accuracy in detection of gastric carcinoma by USG was 80% (24/30 cases) and MDCT was 87% (26/30 cases), with p value of < 0.01 which is significant, which shows CT is better modality for diagnosing gastric carcinoma. For T staging, the efficacy of MDCT and USG was 90% (27/30 cases) and 80% (24/30 cases) respectively. For nodal status, the accuracy of CT is 73.3 %(22/30 cases) and USG is 63.3 %(19/30 cases). For distant metastasis, accuracy was same with USG and CT (70%, 27/30 cases). But when both the modalities are combined, the efficacy improves for diagnosing and staging gastric carcinoma by 93% with P<0.05. The anastomosis degree of the gastric carcinoma between enhanced CT and ultrasonography was κ=0.404 Conclusion: Overall USG and Multi-detector row CT with combined water and air distention can improve the accuracy of preoperative staging of gastric cancer. Comprehensive imaging of US and MDCT is helpful to improve the accuracy of detection and staging of gastric carcinoma.

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“…Endoscopic procedures are used to screen high risk symptomatic patients by detecting morphological changes in gastrointestinal mucosa. Even as a gold standard technique, endoscopic procedures do not allow effective differentiation of neoplastic gastric lesions from healthy or stressed tissue due to their indiscernible microstructural differences [ 40 ]. Nam et al have demonstrated that early detection of GC requires repeated endoscopic procedures owing to the rate of false negatives associated with the procedure [ 41 ].…”

Section: Antibody-fluorescent Dyes For Gc Diagnosismentioning

confidence: 99%

Antibody-Targeted Imaging of Gastric Cancer

et al. 2020

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The specificity of antibodies for antigens overexpressed or uniquely expressed in tumor cells makes them ideal candidates in the development of bioconjugates for tumor imaging. Molecular imaging can aid clinicians in the diagnosis of gastric tumors and in selecting patients for therapies targeting receptors with a heterogeneous intratumoral or intertumoral expression. Antibodies labeled with an imaging radiometal can be used to detect primary tumors and metastases using whole-body positron emission tomography (PET) or single photon emission computed tomography (SPECT), both during diagnosis and monitoring disease response. Conjugated with fluorescent dyes, antibodies can image tumors by targeted optical imaging. This review provides an overview of the most recent advances in the use of antibodies labeled with radiometals or conjugated with fluorescent dyes for gastric cancer imaging.

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Early Gastric Cancer: Current Advances of Endoscopic Diagnosis and Treatment

Cited by 30 publications

References 65 publications

Clinical Utility of a STAT3-Regulated miRNA-200 Family Signature with Prognostic Potential in Early Gastric Cancer

Clinical Utility of a STAT3-Regulated miRNA-200 Family Signature with Prognostic Potential in Early Gastric Cancer

Comparative Study of Transabdominal Ultrasonography and Multidetector Row Computed Tomography in Preoperative Staging of Gastric Carcinoma

Antibody-Targeted Imaging of Gastric Cancer

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