Early glottic cancer recurrence: A critical review on its current management

Locatello, Luca Giovanni; Bruno, Chiara; Gallo, Oreste

doi:10.1016/j.critrevonc.2021.103298

Cited by 9 publications

(13 citation statements)

References 183 publications

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“…However, this procedure is associated with long postoperative recovery time and changes in laryngeal function to a variable extent. 3 Numerous studies indicate the benefits of using low-temperature plasma radiofrequency ablation technology in the field of head, neck, ear, nose and throat, since it is associated with less trauma and bleeding and fast postoperative recovery. In recent years, low-temperature plasma radiofrequency ablation was used as laryngeal minimally invasive surgery to treat early glottis carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effects of low-temperature plasma radiofrequency ablation and partial laryngectomy for glottis cancer: A comparative study

Zhu¹,

Lin

2023

Pak J Med Sci

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Objective: To compare the therapeutic effects of low-temperature plasma radiofrequency ablation and partial laryngectomy in the treatment of early glottis carcinoma. Methods: Clinical data of 80 patients with early glottis carcinoma treated in our hospital from June 2019 to January 2021 were analyzed. Patients were retrospectively divided into two groups based on the type of intervention. Forty patients received partial laryngectomy (Control group) and 40 patients received low-temperature plasma radiofrequency ablation (Observation group). Surgical indexes, length of hospital stay, postoperative complications, and visual analog scale (VAS) score of postoperative pain of patients in the two groups were compared. Postoperative stress response indexes, clinical efficacy, and postoperative recovery in two groups were compared and analyzed. Results: The operation time, hospital stay, intraoperative bleeding, and the incidence of postoperative complications in the observation group were significantly lower than those in the Control group (P<0.05). The postoperative pain VAS scores, Levels of malondialdehyde (MDA) and glutathione (GSH) in the observation group were significantly lower than those in the control group (P<0.05), while the level of nitro tyrosine (3-NT) and superoxide dismutase (SOD) were significantly higher than that in the control group (P<0.05). After a one-year follow-up, the excellent and good rate of pronunciation function in the observation group (95%) was significantly higher than control group (75%) (P<0.05). Conclusions: Low-temperature plasma radiofrequency ablation in the treatment of early glottis carcinoma is associated with less trauma, short operation time, less bleeding, short hospital stay and low postoperative stress reaction rate. Compared with partial laryngectomy, it has higher safety and better postoperative vocal cord function recovery. doi: https://doi.org/10.12669/pjms.39.2.6847 How to cite this: Zhu K, Lin R. Therapeutic effects of low-temperature plasma radiofrequency ablation and partial laryngectomy for glottis cancer: A comparative study. Pak J Med Sci. 2023;39(2):---------. doi: https://doi.org/10.12669/pjms.39.2.6847 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Introductionmentioning

confidence: 99%

Therapeutic effects of low-temperature plasma radiofrequency ablation and partial laryngectomy for glottis cancer: A comparative study

Zhu¹,

Lin

2023

Pak J Med Sci

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“…The current evidence is poor to drive medical decisions. The controversies come from positive results of studies with low quality and with significant limitations comparing both modalities 7,8 …”

Section: Introductionmentioning

confidence: 99%

“…The controversies come from positive results of studies with low quality and with significant limitations comparing both modalities. 7,8 In 2014, Warner et al conducted a Cochrane systematic review to determine if S or RT would better treat early-stage glottic cancer (EGC). 8 The systematic review identified only one randomized clinical trial (RCT) comparing RT and S. 8 The conclusion was that although the RCT had shown no significant difference in survival, the interpretation was limited because of concerns about shortcomings in the study design and analysis.…”

Section: Introductionmentioning

confidence: 99%

Real‐world evidence for oncological outcomes after radiotherapy or surgery for T1a‐T1b glottic squamous cell carcinoma: A population‐based cohort study

et al. 2023

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BackgroundCompare outcomes after surgery (S) or radiotherapy (RT) for T1a‐T1b glottic squamous cell carcinoma (T1GSCC) in a population‐based cohort study.MethodsPatients diagnosed with T1GSCC from 1999 to 2020 were identified from a public database. Clinical, demographic, and social data were extracted. Treatment and patient groups and subgroups were compared with log‐rank test, Cox proportional test, and propensity‐score matched (PSM).ResultsEight hundred and eighty‐eight patients with T1GSCC were included in the study, with a median follow‐up of 61 months. The 5‐ and 10‐year overall survival (OS) S versus RT were 76% versus 71% and 60% versus 52% (p = 0.02), respectively. In the subgroup analysis, S was associated with better OS for T1b, male, and public service patients (p < 0.05). In the PSM cohort of S versus RT with 110 patients each, there was no significant difference in the OS, CSS, and LC.ConclusionsT1GSCC has favorable outcomes with S or RT.

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“…Early glottic cancer (EGC) is commonly defined as a squamous-cell carcinoma that does not extend beyond the true vocal cords or impair their motion, and without any clinical or radiological evidence of cervical node involvement [1]. According to the eighth edition of the American Joint Committee on Cancer and Union for International Cancer Control (AJCC/UICC)'s tumor-node-metastasis (TNM) system, EGC corresponds to the T1aN0M0, T1bN0M0 (stage I), and T2N0M0 (stage II) lesions [2].…”

Section: Introductionmentioning

confidence: 99%

“…According to the eighth edition of the American Joint Committee on Cancer and Union for International Cancer Control (AJCC/UICC)'s tumor-node-metastasis (TNM) system, EGC corresponds to the T1aN0M0, T1bN0M0 (stage I), and T2N0M0 (stage II) lesions [2]. Oncological outcomes for EGC are known to be excellent, with reported 5-year disease-specific survival (DSS) of over 80-90% [1,3,4]. Exclusive radiotherapy (RT) or surgery, mostly in the form of transoral laser microsurgery (TLM), are the two main primary treatment options, with comparable results in terms of survival even in the most recent series [1,5].…”

Section: Introductionmentioning

confidence: 99%

The Same–Up–Down Staging System for Recurrent Early Glottic Cancer

Licci

Locatello

Maggiore

et al. 2023

Cancers

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(1) Background: The treatment of recurrent early glottic cancer (rEGC) remains challenging. We wanted to investigate how the oncological outcomes are affected by the initial and recurrent stages, in order to propose our newly developed Same–Up–Down (SUD) staging system. (2) Methods: In our cohort of 258 rEGC patients, we retrospectively assessed the prognostic performances of the rTNM (the TNM staging system for recurrence), CLRSS, CLRSS-2, and SUD staging systems by univariate and multivariate Cox analysis, comparing their predictive capability using Harrell’s C-index. (3) Results: The SUD classification satisfactorily predicted both overall survival (p = 0.022) and second-recurrence-free survival (p = 0.024, as same + down vs. upstage) in our cohort. It also outperformed the other three systems in terms of prediction of survival, with an improvement of 1.52%, 1.18%, and 3.96% in the predictive capacity of overall survival, disease-specific survival, and second-recurrence-free survival, respectively. (4) Conclusions: The SUD staging system can efficiently predict survival in rEGC patients, whose prognosis heavily depends on both the initial and recurrent locoregional extension.

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Early glottic cancer recurrence: A critical review on its current management

Cited by 9 publications

References 183 publications

Therapeutic effects of low-temperature plasma radiofrequency ablation and partial laryngectomy for glottis cancer: A comparative study

Therapeutic effects of low-temperature plasma radiofrequency ablation and partial laryngectomy for glottis cancer: A comparative study

Real‐world evidence for oncological outcomes after radiotherapy or surgery for T1a‐T1b glottic squamous cell carcinoma: A population‐based cohort study

The Same–Up–Down Staging System for Recurrent Early Glottic Cancer

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