Early growth characteristics and the risk of reduced lung function and asthma: A meta-analysis of 25,000 children

Abstract

1Background Children born preterm or with a small-size-for-gestational-age are at increased 2

The effect of early growth patterns and lung function on the development of childhood asthma: a population based study

“…Interestingly, the magnitude of deficits in the FEV 1 /FVC ratio in these studies is similar to that in the present study regarding PWV and BMIAP. Previous studies showed that weight gain in the first 3 months of life was associated with a −0.13 lower FEV 1 /FVC z-score at 8 years,14 a greater PWV with a −0.13 lower FEV 1 /FVC z-score at 15 years,3 and weight gain during the first year of life with a −0.08 lower FEV 1 /FVC z-score between 4 and 19 years of age 22. In our study we showed that BMIAP had a stronger effect on FVC, FEV 1 and the FEV 1 /FVC ratio than PWV, and that this association was consistent after the analysis was restricted to children without asthma.…”

The initiation of metabolic inflammation in childhood obesity

“…Weight gain in infancy is a risk factor for elevated CRP and great carotid intima-media thickness in non-diabetic children (75). Large cohort studies have identified surprising links between infant growth and inflammatory diseases such as type 1 diabetes (76) and asthma (77), suggesting that early rapid growth rates may have broad effects on inflammatory responses to environmental stimuli during childhood. Overall, the immediate postnatal period is clearly a sensitive window for the patterning of nutritional and inflammatory responses that is understudied in the context of metainflammation.…”

The impact of airborne particulate matter on pediatric hospital admissions for pneumonia among children in Jinan, China: A case-crossover study

“…Globally, pneumonia accounts for 15% of all deaths in children less than 5 years of age and was the largest infectious cause of death in children in 2015 (Shibata et al, 2014). Many studies have demonstrated associations between selected air pollutants and adverse health effects in children in the aspects of childhood hospital admissions (Barnett et al, 2005), school absences (Hales et al, 2016), physician visits for upper and lower respiratory illness (Aguilera et al, 2005), and deficits in lung function growth rates (den Dekker et al, 2016). Infectious agents associated with pneumonia include bacteria, viruses, and fungi.…”