Early growth response 1 promoted the invasion of glioblastoma multiforme by elevating HMGB1

Du, Kai; Wu, Xiaoyou; Ji, Xiaofei; Liang, Nan; Li, Zheng

doi:10.23736/s0390-5616.20.05107-3

Cited by 7 publications

(4 citation statements)

References 43 publications

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“…Immunohistochemistry (IHC) was performed with streptavidin peroxidase complex method as previous described ( 23 ). The specimens were deparaffinized and rehydrated with xylene and graded alcohol first, followed by the antigen retrieval in boiled citrate buffer (pH = 6.0) for 30 minutes.…”

Section: Methodsmentioning

confidence: 99%

WDR5 is a prognostic biomarker of brain metastasis from non-small cell lung cancer

Liang²,

Wang³

et al. 2022

Front. Oncol.

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BackgroundLung cancer (LC) is the most frequent caner type and causes the most cancer-related death. Brain metastases (BM) are the deadliest complications of lung cancer, and the prognostic biomarkers of BM are urgently needed.Materials and methodsIn our study, we established an inception cohort including 122 patients with asynchronous BM from NSCLC, and further selected 70 patients who received surgical resection, which compromised the validation cohort. With immunohistochemistry, we investigated the expression of WDR5 in the cohort. By chi-square method, the correlations between WDR5 and clinicopathological factors were analyzed. The prognostic indicators were analyzed with the univariate analysis, and independent prognostic factors were identified by multivariate analysis with Cox-regression model.ResultsWDR5 is frequently expressed in the cytoplasm of BM from NSCLC. Patients with low or high expression of WDR5 account for 60% and 40% respectively. High expression of WDR5 indicates poor prognosis of BM from NSCLC (P=0.001). In addition to WDR5, KPS is also a prognostic factor of BM, and high KPS predicts favorable prognosis (P=0.006). WDR5 is an independent prognostic biomarker for poor prognosis of BM from NSCLC, with the cancer-related odds as 2.48.ConclusionsHigh expression of WDR5 can predict the poor prognosis of BM, and WDR5 is an independent prognostic biomarker of BM from NSCLC. Patients with WDR5 overexpression are more high-risk to suffer BM-related death and should receive more intense post-operational supervision.

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Section: Methodsmentioning

confidence: 99%

WDR5 is a prognostic biomarker of brain metastasis from non-small cell lung cancer

Liang²,

Wang³

et al. 2022

Front. Oncol.

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“…Recent studies have shown that EGR1 is closely related to the initiation and progression of cancer and may participate in tumor cell proliferation, invasion, metastasis, and tumor angiogenesis [41,42]. In particular, high EGR1 levels were detected in prostate cancer [43].…”

Section: Plos Biologymentioning

confidence: 99%

EGR1 drives cell proliferation by directly stimulating TFEB transcription in response to starvation

et al. 2023

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The stress-responsive transcription factor EB (TFEB) is a master controller of lysosomal biogenesis and autophagy and plays a major role in several cancer-associated diseases. TFEB is regulated at the posttranslational level by the nutrient-sensitive kinase complex mTORC1. However, little is known about the regulation of TFEB transcription. Here, through integrative genomic approaches, we identify the immediate-early gene EGR1 as a positive transcriptional regulator of TFEB expression in human cells and demonstrate that, in the absence of EGR1, TFEB-mediated transcriptional response to starvation is impaired. Remarkably, both genetic and pharmacological inhibition of EGR1, using the MEK1/2 inhibitor Trametinib, significantly reduced the proliferation of 2D and 3D cultures of cells displaying constitutive activation of TFEB, including those from a patient with Birt-Hogg-Dubé (BHD) syndrome, a TFEB-driven inherited cancer condition. Overall, we uncover an additional layer of TFEB regulation consisting in modulating its transcription via EGR1 and propose that interfering with the EGR1-TFEB axis may represent a therapeutic strategy to counteract constitutive TFEB activation in cancer-associated conditions.

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“…It is the superiority of the aforementioned induced differentiation therapy that has made differentiation induction a research hotspot in recent years (12)(13)(14)(15). Expression of early growth response-1 (Egr-1) is a member of the early growth response protein family, which has been considered to be of great significance in a variety of physiological processes and has been extensively studied (16,17), especially in cell proliferation, angiogenesis, invasion and immune response of tumors (18,19). Egr-1 can act as a transcriptional regulator by combining the C2H2 type zinc finger with the DNA motif of the 5'-GCG(T/G)GGGCG-3' sequence.…”

Section: Mir-let-7c-3p Targeting On Egr-1 Contributes To the Committe...mentioning

confidence: 99%

miR‑let‑7c‑3p targeting on Egr‑1 contributes to the committed differentiation of leukemia cells into monocyte/macrophages

Wang

Zhao

et al. 2022

Oncol Lett

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Early growth response 1 promoted the invasion of glioblastoma multiforme by elevating HMGB1

Cited by 7 publications

References 43 publications

WDR5 is a prognostic biomarker of brain metastasis from non-small cell lung cancer

WDR5 is a prognostic biomarker of brain metastasis from non-small cell lung cancer

EGR1 drives cell proliferation by directly stimulating TFEB transcription in response to starvation

miR‑let‑7c‑3p targeting on Egr‑1 contributes to the committed differentiation of leukemia cells into monocyte/macrophages

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