2015
DOI: 10.1016/j.bbmt.2014.11.459
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Early Hematopoietic Cell Transplant (HCT) Outcomes of Children with Severe Combined Immunodeficiency Disease (SCID): The First Seventy Four Patients of the Primary Immune Deficiency Treatment Consortium (PIDTC) Prospective Study 6901

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Cited by 3 publications
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“…Second, MD HSC infusion holds the advantage of a low incidence of transplantation-related morbidity in terms of infection, long-term GVHD, and impaired growth or fertility. Conditioning toxicity is one of the major causes of death in SCID patients 19,20 . In countries where newborn screening testing for SCID is not used, the majority of cases without a family history of SCID are complicated by serious infection before HSCT can be administered.…”
Section: Discussionmentioning
confidence: 99%
“…Second, MD HSC infusion holds the advantage of a low incidence of transplantation-related morbidity in terms of infection, long-term GVHD, and impaired growth or fertility. Conditioning toxicity is one of the major causes of death in SCID patients 19,20 . In countries where newborn screening testing for SCID is not used, the majority of cases without a family history of SCID are complicated by serious infection before HSCT can be administered.…”
Section: Discussionmentioning
confidence: 99%
“…18 At 1 year, survival is 92% for typical SCID and 86% for leaky SCID or Omenn syndrome (OS), for this contemporary cohort, but lower for reticular dysgenesis (RD). 19 Clearly, many questions remain and further work is needed to optimize transplant approaches, as discussed further below.…”
Section: Significance and Impact Of Pidtc Publicationsmentioning
confidence: 99%