Early Hepatic Artery Thrombosis After Liver Transplantation: Diagnosis and Treatment

Improvement of the cold storage of blood vessels with a vascular preservation solution. Study in porcine aortic segments

“…37,38 Both might lead to thrombosis and graft occlusion, which could result in the loss of the organ/tissue supplied by the grafted vessel. 39,40 In solution 8 with 0.1 mmol/L deferoxamine ϩ 20 mol/L LK 614, the platelet adherence was significantly reduced compared with HTK solution, indicating lower thrombogenicity.…”

Split-Liver Procedure and Inflammatory Response: Improvement by Pharmacological Preconditioning

“…Thus, vascular complications are associated with poorer prognosis and require early diagnosis and treatment to prevent patient death [2]. Beside surgical technical difficulties, concomitant factors of the donor and the recipient, including inflammation and platelet activation, are thought to be responsible for the vascular complications after liver transplantation [8][9][10][11][12][13][14].…”

“…In most cases, urgent retransplantation is the only option to avoid lethal outcome [8]. Several factors determine the development of vascular complications after liver transplantation, including donor age, liver quality, hepatic arterial anatomy, surgical equipment, and anastomosis technique [9][10][11][12][13][14]. The local and systemic release of pro-inflammatory cytokines with endothelial activation and leukocyte recruitment may play an important role in platelet activation and intravascular coagulation, both contributing to the manifestation of microcirculatory disorders and liver dysfunction [15].…”

Do Postliver Transplant Patients Need Thromboprophylactic Anticoagulation?

“…Nikeghbalian et al reported early (within 2 weeks) HAT rate of 4.3% (11 of 256). 23 In a more recent study (n ¼ 1379 adults, 188 pediatric), incidence of HAT was significantly (P < .001) higher with the use of aortohepatic conduits (4.1% vs 0.7% in adults) with an adjusted hazard ratio for graft loss of 1.38 with the use of conduits. The differences were not observed in children.…”