Early Hits and Long-Term Consequences: Tracking the Lasting Impact of Prenatal Smoke Exposure on Telomere Length in Children

Theall, Katherine P.; McKasson, Sarah; Mabile, Emily; Dunaway, Lauren Futrell; Drury, Stacy S.

doi:10.2105/ajph.2012.301208

Cited by 44 publications

(49 citation statements)

References 12 publications

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“…23,24 Shorter telomere length in adults has also been associated with a history of childhood maltreatment and early adversity. [25][26][27] The impact of early adversity on cellular trajectories is already present in children as shorter telomeres, measured in DNA extracted from blood, buccal swabs, and saliva, have been associated with environmental stress exposure (eg, community disorder and prenatal tobacco exposure), 28,29 and poor caregiving environments for the child (eg, physical maltreatment, institutional care, poverty), although one negative study has been reported. 13,[30][31][32] Collectively these findings suggest that telomere length has utility across the life course, may link early adversity to negative health outcomes, such as obesity and mental illness, even in youth, and foreshadow increased risk.…”

Section: Resultsmentioning

confidence: 99%

“…Our findings fill an important intermediary gap in the growing literature where TL has been associated with both broad environmental/community-level adversity, as well as adverse events experienced directly by the child such as interpersonal violence, institutional care, and prenatal tobacco exposure. 13,[28][29][30][31]40 Even after controlling for child age and maternal education, the link with bTL and family instability persisted, particularly for witnessing family violence. Our findings are consistent with the existing TL studies in adults and youth, as well as fundamental principal of pediatrics: the development and health of children is intricately interwoven with the wellbeing of the entire family system.…”

Section: Discussionmentioning

confidence: 96%

“…Multiple previous studies of TL in children have been reported, including 4 previous studies utilizing buccal-derived TL, 30,31,40,53 2 utilizing salivary derived TL, 28,29 and over a dozen studies using peripheral blood. 24,43,54 Our own pilot data suggest a high correlation of telomere length estimated concurrently from DNA extracted from buccal and blood (paired t test: P = .94, not significantly different), and buccal and saliva samples (paired t test: P = .96, not significantly different; Brett et al in preparation), consistent with the cellular content overlap between these tissues.…”

Section: Figurementioning

confidence: 99%

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The Association of Telomere Length With Family Violence and Disruption

et al. 2014

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WHAT'S KNOWN ON THIS SUBJECT: Poor health in children is associated with exposure to family violence and disruption. Telomere length has been hypothesized to be a lasting biological indicator of exposure to early adversity and potentially predictive of negative health outcomes throughout the life course. WHAT THIS STUDY ADDS:Telomere length reflects exposure to family violence and disruption and may be an early indicator of the biological impact of early adversity. Children exposed to interpersonal violence and family disruptions had significantly shorter telomeres. Gender moderated these associations. abstract BACKGROUND: To enhance the understanding of biological mechanisms connecting early adversity and negative health, we examine the association between family interpersonal violence and disruption and telomere length in youth. These specific exposures were selected because of their established links with negative health consequences across the life-course.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 96%

Section: Figurementioning

confidence: 99%

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The Association of Telomere Length With Family Violence and Disruption

et al. 2014

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“…Algunos agentes asociados con estilos de vida específicos (tabaco, adiposidad, estrés, exposición a la polución, dieta, sedentarismo) y al estrés oxidativo, infecciones, enfermedades crónicas e inflamación pueden acelerar el acortamiento de los telómeros, induciendo daños en el ADN o, más específicamente, en telómeros y afectando a la salud o la esperanza de vida del individuo (1,(30)(31)(32)(33)(34)(35)(36).…”

Section: Introductionunclassified

Telómeros Y Calidad De La Dieta: Una Revision Sistematica

Marti¹,

Echeverría

Morell‐Azanza

et al. 2017

Nutr Hosp

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Palabras clave:Telómeros. Dieta mediterránea. Estrés oxidative. ADN. ResumenFundamento: existen pocos estudios que hayan evaluado la relación entre la calidad de la dieta y la integridad telómerica en humanos. Los telómeros son regiones de ADN no codificante que se encuentran en los extremos de los cromosomas, cuya longitud además de indicar la esperanza de vida, indica el estado global de salud. El objetivo de la presente revisión sistemática es recopilar la evidencia existente sobre la relación entre la longitud de los telómeros y la calidad de la dieta para conocer el impacto que algunos nutrientes, alimentos y patrones dietéticos pueden tener sobre la homeostasis telomérica y por lo tanto, sobre la salud en general. Material y métodos: se realizó una revisión bibliográfica en la base de datos PubMed para identificar los artículos publicados (en inglés o español) hasta diciembre de 2016 que cumplían los siguientes criterios: incluían sujetos humanos; eran estudios transversales; estudios de casos y controles; estudios de cohortes prospectivos o estudios de intervención; que evaluaban la relación de los nutrientes, alimentos o patrones dietéticos con la longitud de los telómeros. La estrategia de búsqueda incluía las siguientes palabras clave: nutrients or food OR food groups OR diet OR dietary pattern OR eating pattern OR dietary habits OR diet type AND telomere attrition OR telomere length. En total, se incluyeron 19 estudios transversales, cinco estudios de casos y controles, cinco estudios de cohortes prospectivos y dos estudios de intervención, incluyendo aquellos artículos que se encontraron por listas de referencias de otras publicaciones. Resultados: se encontraron asociaciones positivas entre la longitud de los telómeros y la adherencia a la dieta mediterránea y el consumo de verduras y frutas. Los resultados obtenidos para otros nutrientes, alimentos o patrones dietéticos fueron incoherentes, aunque parece que las carnes procesadas, los cereales, el alcohol y las bebidas endulzadas podrían estar asociados con telómeros más cortos. Conclusiones: la intervención dietética, y en particular la promoción de una dieta de estilo mediterráneo, podría desempeñar un papel en la protección de la integridad telomérica. Key words:Telomere. Mediterranean diet. Oxidative stress. DNA. AbstractBackground: Few studies have evaluated the relationship between diet quality and telomere integrity in humans. Telomeres are regions of non-coding DNA localized at the end of each chromosome whose length, in addition to indicating life expectancy, indicates an overall health status. The objective of this systematic review is to compile the existing evidence on the relationship between telomere length and diet quality to further explore the impact that some nutrients, foods and dietary patterns may have on telomere homeostasis and therefore, in precision nutrition strategies. Material and methods: A bibliographic review was performed in the PubMed database to identify published articles (in English or Spanish) until December 201...

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“…et al, 2014a;Zhang et al, 2013). In addition, both prenatal exposure and later exposure to tobacco smoke were associated with shorter telomere length (Theall et al, 2013;Babizhayev and Yegorov, 2011;Valdes et al, 2005;Salihu et al, 2014). Therefore, telomere length is a promising biomarker of exposure and of susceptibility to disease (Silins and Hogberg, 2011).…”

Section: Introductionmentioning

confidence: 99%