2020
DOI: 10.1002/jpen.1783
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Early Human‐Milk Metabolome in Cases of Intrauterine Growth–Restricted and Macrosomic Infants

Abstract: Background: Abnormal fetal growth is associated with short-term and long-term metabolic dysregulation and susceptibility to obesity-related disorders. Maternal milk, the ideal source of infantile nutrition, protects from metabolic diseases in adulthood. By applying nuclear magnetic resonance (NMR) metabolomics, this study investigated the metabolic profile of early human milk/colostrum (EHM/C) at the extremes of fetal-growth conditions, which could affect its nutritional value. Methods: From 98 mothers deliver… Show more

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Cited by 11 publications
(22 citation statements)
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“…GP metabolism is significantly affected in a variety of diseases associated with pregnancy, such as preeclampsia 39 , recurrent miscarriage 40 , placental syncytiotrophoblast microvesicles in adverse pregnancy 41 , and early in utero growth restriction of breast milk and macrosomic babies 42 , which indicates that the process of pregnancy may cause a disturbance in the metabolism of GPs. Some GPs are involved in signaling pathways for cell survival and inflammation and affect membrane-associated proteolysis 43 .…”
Section: Discussionmentioning
confidence: 99%
“…GP metabolism is significantly affected in a variety of diseases associated with pregnancy, such as preeclampsia 39 , recurrent miscarriage 40 , placental syncytiotrophoblast microvesicles in adverse pregnancy 41 , and early in utero growth restriction of breast milk and macrosomic babies 42 , which indicates that the process of pregnancy may cause a disturbance in the metabolism of GPs. Some GPs are involved in signaling pathways for cell survival and inflammation and affect membrane-associated proteolysis 43 .…”
Section: Discussionmentioning
confidence: 99%
“…Three studies have addressed potential influence of HM metabolome on infant growth pattern early in life, and results are largely indecisive and designs disparate [20,29,38]. Of these, Alexandre-Gouabau et al [29] examined preterm infants, whereas Briana et al [38] and Dessì et al [20] encompassed term deliveries of infants with abnormal growth in foetal stage or at delivery.…”
Section: Impact Of Human Milk Metabolome On Infant Growth and Metabolic Developmentmentioning
confidence: 99%
“…Three studies have addressed potential influence of HM metabolome on infant growth pattern early in life, and results are largely indecisive and designs disparate [20,29,38]. Of these, Alexandre-Gouabau et al [29] examined preterm infants, whereas Briana et al [38] and Dessì et al [20] encompassed term deliveries of infants with abnormal growth in foetal stage or at delivery. Moreover, while samples of Alexandre-Gouabau et al [29] were collected at two time points at week 2 and week 4 postpartum, Briana et al [38] and Dessì et al [20] sampled once at day 3 or 4 postpartum.…”
Section: Impact Of Human Milk Metabolome On Infant Growth and Metabolic Developmentmentioning
confidence: 99%
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