Early identification of bacteremia by biochemical markers of systemic inflammation

Rintala, Esa; Aittoniemi, Janne; Laine, Seppo; Nevalainen, T J; Nikoskelainen, J

doi:10.1080/003655101753218283

Cited by 34 publications

(27 citation statements)

References 25 publications

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“…All the studies conducted were prospective cross-sectional studies involving only human subjects. Only one study was published before the year 2000[26], whereas, the other three studies were published between the year 2001 to 2016[27, 29, 30]. All the four studies had a sample size of less than 100, ranging from 29 to 80 participants.…”

Section: Resultsmentioning

confidence: 99%

“…The release of sPLA2-IIA in these conditions is induced by inflammatory cytokines such as interleukin IL-6, IL-1β and tumor necrosis factor (TNF-α), which are key factors in the process of neutrophil adhesion and migration [23–25]. Whilst the exact role of sPLA2-IIA in sepsis is still debatable, several small clinical trials have already shown that plasma levels of sPLA2-IIA exhibited positive correlation with subsequent diagnosis of bacteremia [26, 27]. Hence, in this systematic review, we aim to investigate the role of sPLA2-IIA as a biomarker for the detection of sepsis and bacterial infection in adults.…”

Section: Introductionmentioning

confidence: 99%

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The role of group IIA secretory phospholipase A2 (sPLA2-IIA) as a biomarker for the diagnosis of sepsis and bacterial infection in adults—A systematic review

Tan

Goh

2017

PLoS ONE

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IntroductionThis paper investigates the role of Group II Secretory Phospholipase A2 (sPLA2-IIA) as a biomarker for the diagnosis of sepsis and bacterial infection in adults. Sepsis and bacterial infection are common problems encountered by patients in the hospital and often carry adverse outcomes if not managed early.MethodsTwo independent reviewers conducted a comprehensive search using Ovid MEDLINE published from years 1993 to 2016 and SCOPUS published from year 1985 to 2017 to screen for relevant studies. The main inclusion criteria included adult subjects, patients with suspected or confirmed signs of infection and relevant outcomes which looked into the role of sPLA2-IIA in detecting the presence of sepsis and bacterial infection in the subjects.Results and discussionFour studies met the inclusion criteria. SPLA2-IIA was found to be effective in detecting the presence of sepsis and bacterial infection in adults. The levels of serum sPLA2-IIA also correlated well with the presence of sepsis and bacterial infection.ConclusionThis systematic review highlights the role of sPLA2-IIA as a reliable tool to diagnose sepsis and bacterial infection in adult patients. Nonetheless, further studies should be done in the future to provide more compelling evidence on its application in the clinical setting.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The role of group IIA secretory phospholipase A2 (sPLA2-IIA) as a biomarker for the diagnosis of sepsis and bacterial infection in adults—A systematic review

Tan

Goh

2017

PLoS ONE

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“…sPLA 2 was proposed as a sensitive marker of sepsis in adults as sPLA 2 reflects earlier biological events than CRP and the concentration declines earlier. 12,27 In this study, the diagnostic performance of sPLA 2 for suspected infection and sepsis was less than that of CRP, and better than I/T ratio. In clinical practice, newborn infants with clinical signs of infection receive antibiotics even when laboratory investigations are not suggestive of bacterial infection.…”

Section: Discussionmentioning

confidence: 58%

“…8,10,11 In adults, sPLA 2 is proposed as a sensitive marker for sepsis, and increased plasma levels of sPLA 2 are associated with development of multiple organ failure, vascular dilatation during shock and death. 6,7,12 The role of sPLA 2 in neonatal sepsis is unknown and its levels and relationship with well-recognized markers of inflammation have not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Secretory phospholipase A2 in newborn infants with sepsis

et al. 2008

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Objective: To investigate secretory phospholipase A 2 (sPLA 2 ) activity in neonatal sepsis.Study Design: Plasma sPLA 2 activity, C-reactive protein (CRP) concentration, leukocyte count and immature/total neutrophil (I/T) ratio were assessed in a group of 156 infants admitted for neonatal intensive care, who were classified as documented sepsis (n ¼ 24), suspected infection (n ¼ 77) and controls (n ¼ 55). Interleukin-6 (IL-6) concentrations were assessed in a subgroup (n ¼ 29).Result: sPLA 2 activity, CRP concentration and I/T ratio were higher in sepsis than in suspected infection or control groups. sPLA 2 activity advanced with increasing CRP, I/T ratio and IL-6 was highest in infants with respiratory distress syndrome (RDS). Compared to CRP, sPLA 2 had equal sensitivity and lower specificity. Compared to I/T ratio, sensitivity and specificity of sPLA 2 were higher.Conclusion: Plasma sPLA 2 activity is increased in neonatal sepsis and highest in infants with RDS. Further studies should assess the potential of sPLA 2 inhibition in neonatal sepsis.

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“…C-reactive protein (CRP) has been used for predicting sepsis patient (21,22). In this years several markers have developed as sepsis markers such as LBP and procalcitonin (23,24).…”

Section: Discussionmentioning

confidence: 99%

Lipopolysaccharide Binding Protein, Soluble-Intercellular Adhesion Molecule-1, Procalcitonin, and Protein C Activity and Clinical Outcome in Systemic Inflammatory Response Syndrome (SIRS) or Sepsis Patients

2009

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BACKGROUND: Biochemical markers may be used in diagnosis, prognostic and monitoring treatment and therapy for sepsis patients. In this study we used Lipopolysacharide Binding Protein (LBP), serum-Intercellular Adhesion Molecule-1 (ICAM-1), Procalcitonin (PCT) and protein C activity. LBP is related to lipopolysachharide or gram-negative bacterial endotoxin which bound to LBP and induced inflammatory response. ICAM-1 is associated with endothelial dysfunction in response to systemic inflammatory and septic condition. PCT increased in bacterial infection and in severe systemic inflammatory. Role of Protein C is protecting the intravascular system to systemic inflammation, sepsis and the concomitant intravascular coagulopathy. The aim of this study was to examine the associations between levels of serum LBP, sICAM-1, PCT, and protein C activity with the clinical outcome of SIRS or sepsis patients.METHODS: We included 19 post surgery patients with SIRS criteria from intensive care unit (ICU) and evaluated the level of LBP serum with Chemiliuminescent Enzyme Immunoassay (Diagnostic Product Co.), ICAM-1 with ELISA (R&D System), PCT with immunochromatography (BRAHMS), protein C activity with chromogenic method (Dade Behring). We performed the samples serially at the first admission of patients and after 72 hours. Data were analysed by non-parametric with Wilcoxon test and Mann-Whitney test. Correlation study between biomarkers calculated by Kendall’s tau and Spearman’s rho.RESULTS: Of 19 patients, 9 (47,4%) died and 10 (52,6%) surviving. The level of LBP serum decreased after 72 hours in surviving-sepsis patients, and increased in nonsurviving sepsis patients with significant different levels at 72 hours examination (P<0.05). The level of soluble-ICAM-1 which was high in the first admission showed in non-surviving sepsis patients, but the difference levels was not significant between surviving and non-surviving patients (P>0.05). In all patients were found high level of PCT serum since the first admission examination, decreasing levels were occurred significantly in surviving patients after 72 hours (P<0.05) where high PCT levels were found in non-surviving patients after 72 hours. The median level of plasma protein C activity was low at the first admission especially in non-surviving sepsis patients, the decreasing level was not significantly different after 72 hours (P>0.05) both in surviving and non-surviving patients.CONCLUSIONS: Increasing level of LBP and PCT in sepsis patients showed that those biomarkers useful for predict the clinical outcome in sepsis patients. Decreasing protein C activity level was not a good predictor in worsening clinical outcomes. Soluble ICAM-1 level was not a good marker for predict risk of sepsis severity. LBP and PCT tests were more useful in serially testing from the first admission of sepsis patients, those tests are more faster than bacterial culture.KEYWORDS: Sepsis, SIRS, Lipopolysachharide Binding Protein, soluble- Intercellular Adhesion Molecule-1, Procalcitonin, Protein C

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Early identification of bacteremia by biochemical markers of systemic inflammation

Cited by 34 publications

References 25 publications

The role of group IIA secretory phospholipase A2 (sPLA2-IIA) as a biomarker for the diagnosis of sepsis and bacterial infection in adults—A systematic review

The role of group IIA secretory phospholipase A2 (sPLA2-IIA) as a biomarker for the diagnosis of sepsis and bacterial infection in adults—A systematic review

Secretory phospholipase A2 in newborn infants with sepsis

Lipopolysaccharide Binding Protein, Soluble-Intercellular Adhesion Molecule-1, Procalcitonin, and Protein C Activity and Clinical Outcome in Systemic Inflammatory Response Syndrome (SIRS) or Sepsis Patients

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