Early Identification of Subtle Left Ventricular and Atrial Dysfunction among Asymptomatic Survivors of Childhood Myeloid Leukemia: Insights from the Novel Three-Dimensional Speckle Tracking Echocardiography

Left atrial function in children and young adult cancer survivors treated with anthracyclines

“…In adults, anthracycline exposure is associated with a significant change in LA GLS . In survivors of pediatric cancer exposed to anthracyclines, peak negative LA strain, LA reservoir, and LA booster pump function were reduced . However, in children and young adults, little is known about the acute effects of anthracycline exposure on LA function.…”

“…9 In survivors of pediatric cancer exposed to anthracyclines, peak negative LA strain, 10 LA reservoir, and LA booster pump function were reduced. 11 However, in children and young adults, little is known about the acute effects of anthracycline exposure on LA function. Much of the published pediatric literature focuses on the change in LV function following anthracycline exposure, [12][13][14] for which there is a strong relationship.…”