Early identification of women with HELLP syndrome who need plasma exchange after delivery

Serum levels of ET-1, M30, and angiopoietins-1 and -2 in HELLP syndrome and preeclampsia compared to controls

“…Although there are some promising predictive biomarkers, none of them has yet proven to be sensitive and specific enough for clinical practice [26][27][28]. If diagnosed early and managed properly, HELLP syndrome in most patients usually starts to improve within the first 24-48 h after delivery [29]. ETs, 21-amino acid peptides, are mainly secreted from vascular endothelial cells and regulate vascular homeostasis.…”

Recurrent HELLP Syndrome at 22 Weeks of Gestation

“…We think that prompt intervention in first pregnancy prevented the progression of HELLP syndrome to its most severe form (1st stage of syndrome according to Mississippi classification) and from developing more serious maternal complications. Rapid worsening of laboratory findings and clinical symptoms is linked to higher maternal morbidity especially in early cases of HELLP syndrome [ 13 , 14 ]. The indication of caesarean section in 2nd pregnancy was highly influenced by the previous surgery.…”

The Use of Plasma Exchange in a Very Early-onset and Life Threatening, Hemolysis, Elevated Liver Enzymes, and Low Platelet (HELLP) Syndrome: A Case Report

“…However, some research demonstrated that postpartum plasma exchange therapy improves treatment outcomes in patients with severe HELLP syndrome [11,[15][16][17]. Patients who do not show improvement of platlets and ASAT levels within the first 24 to 48 hours after delivery and patients with renal or neurological involvement may have benefit from plasma-exchange between 24 and 72 hours postpartum as shown by Simetka et al [18].…”