Early immune events during acute HIV infection

Slike, BM; Tassaneetrithep, Boonrat; Nitayaphan, Sorachai; Rono, Kathleen; Sanga, Erica; Sekiziyivu, A; Stablein, Donald M.; Eller, Leigh Ann; Eller, MA; Kim, J; Michael, N; Robb, ML; Marovich, M

doi:10.1186/1742-4690-9-s2-p181

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Tfh Cells In Hiv Pathogenesis1

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2014

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“…Yet, only the chronic phase of IL-6 secretion seems to be responsible for driving subsequent T FH expansion[64]. Interestingly, a similar biphasic IL-6 response has been demonstrated in acute HIV infection[65], but an association with human T FH cell expansion in HIV remains to be shown. Nevertheless, studies of SIV infection have shown that T FH expansion is strongly linked to a skewing in the IL-6 signaling axis[22].…”

Section: Tfh Cells In Hiv Pathogenesismentioning

confidence: 99%

Emerging concepts on T follicular helper cell dynamics in HIV infection

Pissani

Streeck

2014

Trends in Immunology

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Inducing cross-reactive broadly neutralizing antibody (bNAb) responses to HIV through vaccination remains an insurmountable challenge. T follicular helper cells (TFH) are fundamental for the development of antigen-specific antibody responses and therefore critical for anti-HIV vaccine design. Here we review recent studies supporting an intricate involvement of TFH in HIV pathogenesis and bNAb development in HIV infection. We also examine emerging data suggesting that TFH responses may be traceable in peripheral blood, and discuss the implications of these findings in the context of vaccine design and future research in TFH immunobiology.

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Section: Tfh Cells In Hiv Pathogenesismentioning

confidence: 99%