Early impact of hormone replacement therapy on vascular hemodynamics detected via ocular colour Doppler analysis

Atalay, Ender; Karaali̇, Kami̇l; Akar, Münire Erman; Ari, Eylem Şeker; Şi̇mşek, Mehmet; Atalay, Selda; Zorlu, Gürkan

doi:10.1016/j.maturitas.2004.06.023

Cited by 20 publications

(14 citation statements)

References 32 publications

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“…Another possible explanation is the counter-current distribution of drugs, which consists in the distribution of drugs from veins to arteries based on their different gradients; in particular, counter-current transport could occur between veins draining the nasal mucosa with a high concentration of E2 and nearby arteries such as the carotid so that E2 concentration in local arteries could be higher than in peripheral arteries 11) . Our results are in agreement with literature about the vasodilatory effects of both endogenous and exogenous E2 [14][15][16][17][18] on cerebrovascular and ocular circulation. Krejza et al 14) analyzed cerebrovascular impedance during the menstrual cycle and demonstrated a positive effect of E2 infusion on blood flow.…”

Section: Disclosuressupporting

confidence: 93%

“…Krejza et al 14) analyzed cerebrovascular impedance during the menstrual cycle and demonstrated a positive effect of E2 infusion on blood flow. Atalay et al 15) demonstrated that 6-month therapy with 17-beta E2 valerate 2 mg plus ciproterone acetate 1 mg is able to improve ocular vascular Doppler indices. Our results are also in partial agreement with those from Sahin and coworkers who demonstrated a significant decrease in the pulsatility and resistive indices of the central retinal artery but not of the ophthalmic artery in 30 healthy postmenopausal women receiving a single nasal dose of E2 19) ; methodological and technical aspects may account for this partial discrepancy.…”

Section: Disclosuresmentioning

confidence: 99%

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Ophthalmic Artery Vasodilation after Intranasal Estradiol Use in Postmenopausal Women

Ciccone

Cicinelli

Alessio

et al. 2012

JAT

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Aim:The study aim was to evaluate the acute hemodynamic effects of intranasal 17-beta-estradiol on ophthalmic arterial circulation in postmenopausal women. Methods: Twenty-one healthy women in natural menopause for at least 6 months (mean age: 53.2± 2.9 years) were investigated. Each patient received 300 μg intranasal 17-beta-estradiol. We evaluated the heart rate, systolic and diastolic blood pressure, ophthalmic artery velocity at systolic and diastolic peak and its flow curve integral (FCI) before and 30, 60 and 180 minutes after the administration of the drug. Results: At all time points, the ophthalmic artery FCI showed statistically significant variations (p＜ 0.001) of velocity (cm/sec) compared to T0 (speed recorded at baseline before drug administration). Moreover, systolic blood pressure, diastolic blood pressure and heart rate did not significantly differ each other after drug administration. Conclusions: Administration of a single dose of intranasal 17-beta-estradiol to healthy postmenopausal women increases ophthalmic artery perfusion.

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Section: Disclosuressupporting

confidence: 93%

Section: Disclosuresmentioning

confidence: 99%

Ophthalmic Artery Vasodilation after Intranasal Estradiol Use in Postmenopausal Women

Ciccone

Cicinelli

Alessio

et al. 2012

JAT

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“…Progesterone antagonizes the estrogen-dependent vasodilatation and causes an increase in vascular resistance [25]. Reports in the literature have indicated that HRT reduces vascular resistance in either the central retinal artery or the ophthalmic artery, or both [26][27][28][29][30]. One study showed that IOP increased during the premenstrual period and decreased during ovulation [31].…”

Section: Discussionmentioning

confidence: 99%

The effects of different hormone replacement therapy regimens on tear function, intraocular pressure and lens opacity

Uncu

Avcı

Uncu

et al. 2006

Gynecological Endocrinology

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“…In addition to contraception, EE2 is also widely used in the management of menopausal and postmenopausal syndrome, physiological replacement therapy in deficiency states, and the treatment of prostatic and breast cancer in postmenopausal women (Peter 1990;Tyler et al 1998;Birkett and Lester 2003;Atalay et al 2005). This synthetic hormone is of particular concern due to its high persistence in the environment and estrogenic activity.…”

Section: Introductionmentioning

confidence: 99%

Occurrence and fate of steroid estrogens in the largest wastewater treatment plant in Beijing, China

Zhou

Zha

Wang

2011

Environ Monit Assess

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Concern over steroid estrogens has increased rapidly in recent years due to their adverse health effects. Effluent discharge from wastewater treatment plants (WWTPs) is the main pollutant source for environmental water. To understand the pollutant level and fate of steroid estrogens in WWTPs, the occurrence of estrone (E1), 17-β-estradiol (E2), estriol (E3), and 17-β-ethinylestradiol (EE2) was investigated in the Gaobeidian WWTP in Beijing, China. Water samples from influent as well as effluent from second sedimentation tanks and advanced treatment processes were taken monthly during 2006 to 2007. In influent, steroid estrogen concentrations varied from 11.6 to 1.1× 10 2 ng/l, 3.7 to 1.4×10 2 ng/l, no detection (nd) to 7.6×10 2 ng/l and nd to 3.3×10 2 ng/l for E1, E2, E3, and EE2, respectively. Compared with documented values, the higher steroid estrogen concentrations in the WWTP influent may be due to higher population density, higher birthrate, less dilution, and different sampling time. Results revealed that a municipal WWTP with an activated sludge system incorporating anaerobic, anoxic, and aerobic processes could eliminate natural and synthetic estrogens effectively. The mean elimination efficiencies were 83.2%, 96.4%, 98.8%, and 93.0% for E1, E2, E3, and EE2, respectively. The major removal mechanism for natural estrogens and synthetic estrogen EE2 were biodegradation and sorption on the basis of mass balance in water, suspension particles, and sludge. In the WWTP effluent, however, the highest concentrations of E1, E2, E3, and EE2 attained were 74.2, 3.9, 5.1, and 4.6 ng/l, respectively. This is concerning as residual steroid estrogens in WWTP effluent could lead to pollution of the receiving water. Advanced flocculation treatment was applied in the WWTP and transformed the residual estrogen conjugates to free species, which were reduced further by filtration with removal shifting from 32% to 57% for natural estrogen, although no EE2 was removed.

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Early impact of hormone replacement therapy on vascular hemodynamics detected via ocular colour Doppler analysis

Cited by 20 publications

References 32 publications

Ophthalmic Artery Vasodilation after Intranasal Estradiol Use in Postmenopausal Women

Ophthalmic Artery Vasodilation after Intranasal Estradiol Use in Postmenopausal Women

The effects of different hormone replacement therapy regimens on tear function, intraocular pressure and lens opacity

Occurrence and fate of steroid estrogens in the largest wastewater treatment plant in Beijing, China

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