Early improvement in PANSS‐30, PANSS‐8, and PANSS‐6 scores predicts ultimate response and remission during acute treatment of schizophrenia

Lin, Ching‐Hua; Lin, Huey Shyan; Lin, Shuwen; Kuo, Chao-Chan; Wang, F.-C.; Huang, Yuhui

doi:10.1111/acps.12849

Cited by 62 publications

(42 citation statements)

References 35 publications

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“…This is thus another potential application of PANSS‐6. Since shorter scales are preferable and since the two items dropped from PANSS‐8 to get to PANSS‐6 do not seem to add value to the predictive model presented by Lin et al , it seems that the use of the more parsimonious PANSS‐6 is preferable.…”

Section: Discussionmentioning

confidence: 96%

“…To serve this function, however, a valid PANSS‐6 total score threshold for TRS would need to be determined in a study dedicated to this purpose in which PANSS‐6 is compared to other measures that have previously been used for the symptom severity definition of TRS – such as PANSS‐30 or BPRS . Finally, it should be mentioned that Lin et al recently showed that early improvement in the total score of both PANSS‐6 and PANSS‐8 (the six items from PANSS‐6 plus item G5 Mannerisms and posturing and item G9 Unusual thought content) were predictive of subsequent response to antipsychotic treatment. This is thus another potential application of PANSS‐6.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies employing IRT analysis have shown that the widely used 30‐item Positive and Negative Syndrome Scale (PANSS‐30) quite consistently fails to demonstrate scalability in studies of patients with schizophrenia . Therefore, using the PANSS‐30, total score as a measure of severity of schizophrenia is not advisable from a measurement perspective .…”

Section: Introductionmentioning

confidence: 99%

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The validity and sensitivity of PANSS‐6 in treatment‐resistant schizophrenia

Østergaard

Foldager

Mors

et al. 2018

Acta Psychiatr Scand

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The validity and sensitivity of PANSS‐6 in treatment‐resistant schizophrenia

Østergaard

Foldager

Mors

et al. 2018

Acta Psychiatr Scand

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“…First, ALFF ratio in the present study may assist in the treatment selection and personalization of treatment algorithms. Specifically, for patients who show no response within the first two weeks of early treatment, this may predict a failure in the future (Leucht, Busch, Kissling, & Kane, ; Lin et al, ; Murawiec & Boutros, ; Samara et al, ). In other words, patients classified as non‐responders at the end of the current hospitalization are unlikely to be responsive to conventional dopamine D2 antagonists, or to other similar antipsychotics that work by the same mechanism.…”

Section: Discussionmentioning

confidence: 99%

Prediction of early response to overall treatment for schizophrenia: A functional magnetic resonance imaging study

et al. 2019

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Introduction Treatment response at an early stage of schizophrenia is of considerable value with regard to future management of the disorder; however, there are currently no biomarkers that can inform physicians about the likelihood of response. Objects We aim to develop and validate regional brain activity derived from functional magnetic resonance imaging (fMRI) as a potential signature to predict early treatment response in schizophrenia. Methods Amplitude of low‐frequency fluctuation (ALFF) was measured at the start of the first/single episode resulting in hospitalization. Inpatients were included in a principal dataset ( n = 79) and a replication dataset ( n = 44). Two groups of healthy controls ( n = 87; n = 106) were also recruited for each dataset. The clinical response was assessed at discharge from the hospital. The predictive capacity of normalized ALFF in patients by healthy controls, ALFF ratio , was evaluated based on diagnostic tests and clinical correlates. Results In the principal dataset, responders exhibited increased baseline ALFF in the left postcentral gyrus/inferior parietal lobule relative to non‐responders. ALFF ratio of responders before treatment was significantly higher than that of non‐responders ( p < 0.001). The area under the receiver operating characteristic curve was 0.746 for baseline ALFF ratio to distinguish responders from non‐responders, and the sensitivity, specificity, and accuracy were 72.7%, 68.6%, and 70.9%, respectively. Similar results were found in the independent replication dataset. Conclusions Baseline regional activity of the brain seems to be predictive of early response to treatment for schizophrenia. This study shows that psycho‐neuroimaging holds promise for influencing the clinical treatment and management of schizophrenia.

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“…Based on the findings of Lin et al [1], the 30-item Positive and Negative Syndrome Scale (PANSS-30) has not been scalable according to the Rasch analyses, whereas the PANSS-6 which consists of items on delusions (P1), conceptual disorganization (P2), hallucinations (P3), blunted affect (N1), social withdrawal (N4), and lack of spontaneity and flow of conversation (N6) has been scalable [2,3]. The item response theory (IRT), which has been developed by Rasch, is used to identify the items covering the low end of the dimension, the severe end of the dimension, and part of the dimension [4].…”

Section: Introductionmentioning

confidence: 99%

Establishing the cut-off scores for the severity ranges of schizophrenia on the BPRS-6 scale: findings from the REAP-AP

Park

Jang

Kim

et al. 2019

Psychiatry and Clinical Psychopharmacology

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Objective: Using data from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics (REAP-AP), our study aimed to establish the remission and severity ranges (mild, moderate, and severe) of schizophrenia on the Brief Psychiatric Rating Scale-6 (BPRS-6). Methods: A total of 1,438 patients with schizophrenia from India, Indonesia, Japan, Malaysia, and Taiwan were enrolled in the study. Using the receiver operating characteristic (ROC) curve analyses, the optimal cut-off scores for the remission and severity ranges on the BPRS-6 were established. Results: The scalability of the BPRS-6 was considered to have an acceptable "unidimensionality" (coefficient of scalability = 0.43). The cut-off scores for the remission of schizophrenia and mild, moderate, and severe schizophrenia can be optimally defined as the BPRS-6 total score of <5, 5-9, 10-19 and >20, respectively. Conclusion: The BPRS-6 can be a promising, brief, and unidimensional rating scale to supplement the measurement-based care of schizophrenia. ARTICLE HISTORY

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Early improvement in PANSS‐30, PANSS‐8, and PANSS‐6 scores predicts ultimate response and remission during acute treatment of schizophrenia

Abstract: PANSS-8 and PANSS-6 are clinically useful measures. Early improvement, regardless of whether PANSS-30, PANSS-8, or PANSS-6 is used, is a statistically significant predictor of response/remission.

Cited by 62 publications

References 35 publications

The validity and sensitivity of PANSS‐6 in treatment‐resistant schizophrenia

The validity and sensitivity of PANSS‐6 in treatment‐resistant schizophrenia

Prediction of early response to overall treatment for schizophrenia: A functional magnetic resonance imaging study

Establishing the cut-off scores for the severity ranges of schizophrenia on the BPRS-6 scale: findings from the REAP-AP

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