Early-in-life isoflurane exposure alters resting-state functional connectivity in juvenile non-human primates

Neudecker, Viola; Perez-Zoghbi, Jose F.; Miranda-Domínguez, Oscar; Schenning, Katie J.; Ramirez, Julian SB.; Mitchell, A.J.; Perrone, Anders; Earl, Eric; Carpenter, Sam; Martin, Lauren D.; Coleman, Kristine; Neuringer, Martha; Kroenke, Christopher D.; Dissen, Gregory A.; Fair, Damien A.; Brambrink, Ansgar M.

doi:10.1016/j.bja.2023.07.031

British Journal of Anaesthesia

2023

DOI: 10.1016/j.bja.2023.07.031

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Early-in-life isoflurane exposure alters resting-state functional connectivity in juvenile non-human primates

Viola Neudecker,

Jose F. Perez-Zoghbi,

Oscar Miranda-Domínguez

et al.

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Cited by 2 publications

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Needle in a haystack: localising the long-term neuronal changes from early-life exposure to general anaesthesia

Kim,

Weiss,

Raper

2023

British Journal of Anaesthesia

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Needle in a haystack: localising the long-term neuronal changes from early-life exposure to general anaesthesia

Kim,

Weiss,

Raper

2023

British Journal of Anaesthesia

View full text Add to dashboard Cite

Sevoflurane exposure in early life: mitochondrial dysfunction and neurotoxicity in immature rat brains without long-term memory loss

Qiu,

Li,

et al. 2024

Sci Rep

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Neurotoxic effects of general anesthetics, particularly sevoflurane, on pediatric neurodevelopment are a global concern. This study investigated the molecular and metabolic impacts of repeated short exposures to sevoflurane in neonatal rats. Metabolomics analysis revealed significant changes in fatty acid and mitochondrial energy metabolism. Transcriptomic analysis identified altered gene expression related to neurodevelopment and mitochondrial function. Various analyses emphasized upregulation in oxidative phosphorylation and DNA repair pathways. Weighted gene co-expression network analysis (WGCNA) identified key gene modules associated with sevoflurane exposure. Despite these acute changes, no significant long-term memory impairments were detected. These findings highlight the impact of sevoflurane on mitochondrial energy metabolism, oxidative stress, and neuroinflammation, emphasizing its relevance to pediatric neurodevelopment. The absence of substantial long-term memory impairments provides insights into the safety and implications of sevoflurane use in pediatric anesthesia, calling for further research.

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Early-in-life isoflurane exposure alters resting-state functional connectivity in juvenile non-human primates

Cited by 2 publications

References 82 publications

Needle in a haystack: localising the long-term neuronal changes from early-life exposure to general anaesthesia

Needle in a haystack: localising the long-term neuronal changes from early-life exposure to general anaesthesia

Sevoflurane exposure in early life: mitochondrial dysfunction and neurotoxicity in immature rat brains without long-term memory loss

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