Early inadequate or excessive weight loss: A potential contributor to mortality in premature newborns in resource-scarce settings?

Valentine, Gregory C.; Umoren, Rachel; Perez, Krystle

doi:10.1016/j.pedneo.2021.01.004

Cited by 9 publications

(6 citation statements)

References 10 publications

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“…Our study stands out for evaluating weight gain as the primary outcome after OCI treatment and using updated methods, such as the z score and INTERGROWTH-21st growth patterns. We also evaluated weight gain in the critical neonatal period, which is rarely assessed in studies, although it is a determinant of neonatal morbimortality and long-term weight gain (25). We believe that follow-up studies are needed to evaluate the long-term effect of OCI on growth speed, neurodevelopment, and childhood obesity markers to clarify the real bene ts of this immunotherapy in preterm infants.…”

Section: Discussionmentioning

confidence: 99%

Effect of Oropharyngeal Colostrum Immunotherapy on Weight Gain in Very Low Weight Premature Newborns: A Clinical Trial

Cerqueira,

Martins,

Ramos

et al. 2024

Preprint

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Context: The present study evaluated the effect of oropharyngeal colostrum immunotherapy (OCI) on weight gain in preterm newborns with very low birth weight admitted to a public maternal and child care unit. Methods: This is a nonrandomized clinical trial with a historical control of preterm newborns weighing less than 1,500 gat birth who were allocated into two groups according to their neonatal intensive care unit (NICU) admission period: in the control group, those admitted between 2015 and 2018; and in the intervention group, those admitted after the implantation of an OCI protocol between 2018 and 2020. The treatment regimen consisted of eight daily administrations of 0.2 ml (four drops) of colostrum for 10 seconds in the oropharyngeal mucosa every three hours until the child’s seventh day of life. Historical control group data were collected retrospectively using medical records. Weight gain was calculated in grams/kilogram/day and z score by age at 28 days of life. The generalized estimating equation(GEE) method was adopted to evaluate the effect of OCI on weight gain in preterm infants. Results: Greater weight gain was observed in the OCI group between 21 and 28 days (pre-OCI: mean: 11.79; SD: 10.24; OCI: mean: 16.29; SD: 11.72; p=0.05). In multivariate analysis, OCI increased the speed of weight gain by 1.99 g/kg/day (p<0.01) and the z score by age by 0.33 (p<0.01) after adjusting for confounding factors. Conclusion: The OCI favored weight gain and increased the z score by age in the postneonatal period of very low preterm newborns. Study registration: REBEC U1111-1222-0598. Registered 17/12/2018, https://ensaiosclinicos.gov.br/rg/RBR-2cyp7c/

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Section: Discussionmentioning

confidence: 99%

Effect of Oropharyngeal Colostrum Immunotherapy on Weight Gain in Very Low Weight Premature Newborns: A Clinical Trial

Cerqueira,

Martins,

Ramos

et al. 2024

Preprint

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“…4 O perfil tornou-se a maior causa de mortalidade de crianças menores de cinco anos em todo o mundo, com aproximadamente 47%. 2,5 No Brasil, a cada dois óbitos de crianças menores de um ano de idade, um ocorre nos seis primeiros meses de vida. E estudo comprova que uma prevalência estável na prematuridade afeta principalmente as gestantes socialmente vulneráveis, em gestações gemelares e no Norte do Brasil.…”

Section: Introductionunclassified

“…Nesse contexto, considera-se critérios de internação, Peso, Idade Gestacional, Apgar, Tipo de Brazilian Journal of Health Review, Curitiba, v. 7, n. 2, p. 01-13, mar./apr., 2024 parto (Vaginal ou Cesariano), uso de pressão positiva nas vias aéreas, Continuous Positive Airway Pressure (CPAP), na sala de parto ou uso de Intubação Orotraqueal (IOT). 3,5,9,11 Além disso, esse quadro já classifica o bebê como recém-nascido de risco, impondo acompanhamento diferenciado, visto que apresenta maior taxa de morbimortalidade e de desenvolvimento de sequelas incapacitantes a longo prazo, como aumento do risco de doenças cerebrais, paralisia, distúrbios visuais e aumento de doenças crônicas na vida adulta 2,4,5 , compreende-se a importância do avanço nos cuidados dos recém-nascidos para aumento de sobrevida deles, ao minimizar os atrasos no desenvolvimento e analisar as problemáticas que podem surgir a longo prazo. 12 Dessa forma, com objetivo de acrescentar no avanço do tratamento de Recém-Nascidos Pré-Termo (RNPT), para fornecer aos profissionais da área da saúde e hospitais informativos sobre as principais características encontradas foi realizado uma avaliação do perfil e o comprometimento respiratório através da necessidade de uso de ventilação mecânica dos neonatos admitidos em uma UTIN em um hospital de referência, através dos dados obtidos pelos prontuários desses pacientes, para que possa haver mais dados epidemiológicos a fim de melhorar suporte assistencial, tendo em vista diminuir os índices de mortes e comprometimentos.…”

Section: Introductionunclassified

Perfil epidemiológico de pacientes recém-nascidos prematuros na Unidade de Terapia Intensiva neonatal em um hospital de referência da Amazônia brasileira

Pantoja,

Marques,

Pereira

et al. 2024

Braz. J. Hea. Rev.

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O nascimento prematuro pode ser ocasionado por diversos fatores de risco e patologias, dessa forma, torna-se de suma importância o acompanhamento no período neonatal, portanto é de suma importância fornecer aos profissionais da área da saúde e hospitais informativos sobre as principais características encontradas. Avaliar o perfil dos recém-nascidos internados em unidade de terapia intensiva neonatal. Estudo retrospectivo, descritivo e longitudinal. Foram selecionados prontuários de nascidos em instituições e transferidos, internados em unidades de terapia intensiva neonatal, onde idade gestacional, APGAR, peso, tipo de parto e necessidade de ventilação invasiva e não invasiva o apoio foi avaliado. Totalizado 324 prontuários e excluídos 76 por apresentarem informações incompletas, sendo 187 pré-termo, 134 a termo e 3 pós-termo. A cesariana foi 197 e o parto vaginal foi 127. O uso da pressão positiva na sala de parto 191, a intubação nas primeiras 72 horas foi necessária em 127 pacientes comparados a 197. Prematuros com APGAR <7 possuem predisposição para necessidade de suporte ventilatório não invasivo, que pode evoluir para necessidade para intubação devido à sua criticidade.

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“…The multifactorial etiology of BPD includes lack of physiological, early postnatal weight loss in the rst two weeks after birth [5,6]. Thus, early inadequate weight loss is proposed as a common and under-reported contributor to neonatal morbidity and mortality among premature infants [7].…”

Section: Introductionmentioning

confidence: 99%

Correlation between early postnatal body weight changes and lung ultrasound scores as predictors of bronchopulmonary dysplasia in preterm infants: A secondary analysis of a prospective study

Ghanem,

Zozaya,

Ibrahim

et al. 2024

Eur J Pediatr

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Purpose of the study: Recent research links Early Weight-Changes (EWC) with bronchopulmonary dysplasia (BPD) in preterm neonates, while lung ultrasound score (LUS) has shown promise in predicting BPD. We aimed to explore the correlation between LUS and EWC as markers of extravascular lung edema.Objective: To investigate the correlation between LUS and EWC in preterm infants with respiratory distress syndrome regarding future BPD development.Methods: This secondary analysis of a prospective study involved infants ≤ 28 weeks' gestation. Enrolled infants underwent lung ultrasound assessment on postnatal days 3, 7 and 14, measuring LUS.Respiratory severity score (RSS) and EWC were computed on the same time-points. Infants were classi ed as either having BPD or not. Descriptive statistics, Correlation Coe cient, and Area Under the Receiver Operating Characteristic Curve (AUROC) analysis were utilized.Results: Of 132 infants, 70 (53%) had BPD. Univariate analysis revealed statistically signi cant differences in LUS, EWC, and RSS at days 3, 7, and 14 between BPD and no-BPD groups (p < 0.001). A statistically signi cant but weak positive correlation existed between LUS and EWC at all three assessment points. AUROC analysis indicated LUS having superior predictive capacity for the need for invasive mechanical ventilation at day 14 as well as the later BPD development compared to EWC (p < 0.0001).Conclusions: In a cohort of extreme preterm infants, our study revealed a positive yet weak correlation between LUS and EWC, suggesting that EWC was not the major contributing to the evolving chronic lung disease.

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Early inadequate or excessive weight loss: A potential contributor to mortality in premature newborns in resource-scarce settings?

Cited by 9 publications

References 10 publications

Effect of Oropharyngeal Colostrum Immunotherapy on Weight Gain in Very Low Weight Premature Newborns: A Clinical Trial

Effect of Oropharyngeal Colostrum Immunotherapy on Weight Gain in Very Low Weight Premature Newborns: A Clinical Trial

Perfil epidemiológico de pacientes recém-nascidos prematuros na Unidade de Terapia Intensiva neonatal em um hospital de referência da Amazônia brasileira

Correlation between early postnatal body weight changes and lung ultrasound scores as predictors of bronchopulmonary dysplasia in preterm infants: A secondary analysis of a prospective study

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