Early Increase of Oxidative Stress and Soluble CD40L in Children With Hypercholesterolemia

Abstract

Children with hypercholesterolemia have an early increase of oxidative stress that may be responsible for up-regulation of CD40L and potentially predispose to premature atherosclerosis.

Atorvastatin Inhibits gp91 phox Circulating Levels in Patients With Hypercholesterolemia

“…24 -27 Also, several circulating markers of oxidative stress, including 8-OHdG, lipid peroxides, nitrotyrosine, and urinary isoprostanes, are elevated in patients with either polygenic or familial hypercholesterolemia. [5][6][7][8][9] The enzymatic pathway that may be potentially implicated in such a phenomenon has not been fully elucidated. Although we confirm that oxidative stress is enhanced in HC patients, as documented by the elevated values of urinary isoprostanes, the novelty of the present study is the observation of high circulating serum values of sgp91 phox in HC patients compared to controls.…”

“…4 Reduction of several markers of oxidative stress including isoprostanes, , and nitrotyrosine have been observed after statin treatment but the underlying mechanism is still unclear. [5][6][7][8][9] In a pilot study performed in patients with chronic granulomatous disease (X-CGD), a very rare life-threatening disease secondary to hereditary deficiency of gp91 phox (the catalytic subunit of phagocyte NADPH oxidase), we found a significant reduction of urinary isoprostanes. 10 Also, in children with hypercholesterolemia, we observed a significant correlation between platelet gp91 phox expression and urinary isoprostanes.…”

Association Between Soluble CD40 Ligand and Hypercholesterolemia in Children and Adolescents

“…Therefore, our result can be related to the age of the participants. However, in that study (19) there was a significant correlation between the sCD40 and 8-OHdG levels in both hypercholesterolemic children and the adult group. In our study, we couldn't find a positive correlation between those parameters.…”

“…According to our findings, there was no significant difference in the 8-OHdG levels of the hypercholesterolemic children compared to the control group. In a previous study, it was shown that the level of 8-OHdG was lower in hypercholesterolemic and normocholesterolemic children than in adults correspondingly (19). This result can be explained by the fact that age is associated with changes of mechanisms controlling oxidative stress and platelet activation.…”

Estado proinflamatorio en niños obesos

“…Además, en este trabajo se observó en los niños obesos niveles mayores de sCD40L, comparados con los controles. La literatura informa valores elevados de esta molécula en adultos con síndrome coronario agudo, hipercolesterolemia, diabetes y obesidad 36,37 , como también en niños con hipercolesterolemia y con diabetes tipo 1 38,39 . No obstante, las investigaciones de este ligando en niños obesos son escasas y discordantes.…”