Early infant feeding and allergic respiratory diseases in Ibb city, Yemen

Abstract

Background Allergic respiratory diseases (ARD) are a highly prevalent health problem affecting infants and children in Yemen. Early infant feeding predisposition to the development of ARD has been a controversial question. The aim of this study is to investigate the association between early feeding before 6 months of age and the development of ARD among children attending Childhood and Maternity Public Hospital (CMPH), Ibb, Yemen Republic. Subjects and methods The study population included 151 child patients attending the pediatric clinic at CMPH. Upon clinical and laboratory examinations, 72 out of 151 patients had ARD, while the other 79 had diseases other than ARD; all of them were used in risk assessment. Fifteen blood samples from healthy volunteers were used in laboratory investigations as a control. Complete blood count and IgE level were investigated for all participants. Children's parents were requested to give an informed consent and fill questionnaire about demography and history details. Results Early infant feeding was a significant risk factor for the development of ARD with an odds ratio (OR) of 6.8 and 95% confidence interval (CI) 3.0 to 15.3. Artificial milk particularly was risk factor with an OR of 6.1 and 95% confidence interval 2.7 to 13.5. Artificial milk exhibited more wheezing and asthma attack than others (OR 4.3, 95% CI 1.9 to 9.4 and OR 7.6, 95% CI 3.5 to 16.3, respectively). The risk of wheezing and asthma attack also increase with early feeding generally (OR 3.0, 95% CI 1.3 to 7.2 and OR 4.8, 95% CI 2.2 to 8.1, respectively). The patients had a higher sensitization markers than the control, such as eosinophil count and total serum IgE. The highest levels of IgE ever reported existed among early fed patients with artificial milk. Conclusions Early infant feeding, particularly with artificial milk, is a risk factor predisposing infants to the development of allergic respiratory disease presented with more clinical features of wheezing and asthma attack.

A Comprehensive Examination of Exclusive Breastfeeding Through Quranic and Hadith Perspectives Alongside Scientific Insights

“…This implies that breastfeeding can either protect against or at least diminish the risk of asthma in children. A similar pattern was observed in a study by Obaid et al (2022) in Yemen, where infants given formula before six months were more susceptible to asthma attacks than those who were breastfed. Furthermore, breastfeeding contributes to enhanced intelligence in children.…”

Effects of Early Diet on the Prevalence of Allergic Disease in Children: A Systematic Review and Meta-Analysis

“…The risk of bias in randomized controlled trial (RCT) studies was assessed using the Cochrane Collaboration Risk of Bias tool [ 21 ], and the risk of bias in non-RCT trials was assessed using the Risk of Bias in Nonrandomized Studies of Interventions tool [ 22 ]. For all study reports, the summary Tables ( Supplemental Tables 1 and 2 ) [ [8] , [9] , [10] , [11] , [13] , [14] , [15] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] , [72] , [73] , [74] , [75] , [76] , [77] , [78] , [79] , [80] ,…”

“…A meta-analysis of 9 studies (55,302 participants) showed no significant association between the timing of complementary foods introduction and asthma (OR, 0.98; 95% CI: 0.92, 1.04; P = 0.52; moderate heterogeneity [I 2 = 31%], Supplemental Figure 8A ) [ 45 , 48 , 55 , 65 , 79 , [81] , [82] , [83] , 89 ]. Subgroup analyses of the time points (<3 mo compared with <4 mo compared with <6 mo) ( Supplemental Figure 8B ) [ [45] , [48] , [55] , [65] , [79] , [81] , [82] , [83] , [89] ] of complementary food introduction or the end points (0–3 compared with 3–6 compared with 6–12 y) of the outcome assessment ( Supplemental Figure 8C ) [ [48] , [55] , [65] , [79] , [81] , [82] , [83] , [89] ] showed that early introduction of complementary foods was not a protective factor for reduced risk of asthma in the future.…”