Early Inflammation and Risk of Long-Term Development of Heart Failure and Mortality in Survivors of Acute Myocardial Infarction

Suleiman, Mahmoud; Khatib, Rania El; Agmon, Yoram; Mahamid, Riad; Boulos, Monther; Kapeliovich, Michael; Levy, Yishai; Beyar, Rafael; Markiewicz, Walter; Hammerman, Haim; Aronson, Doron

doi:10.1016/j.jacc.2005.10.055

Cited by 240 publications

(207 citation statements)

References 37 publications

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“…Similar results were reported by other authors (11)(12)(13)(14)(15). Researches showed that there is a significant correlation between the CRP with an increased risk of cardiovascular death.…”

Section: Discussionsupporting

confidence: 90%

Troponin and C-reactive Protein in Risk Stratification after Myocardial Infarction

Hodžić¹,

Hasković²,

Duraković³

et al. 2017

Acta Facultatis Medicae Naissensis

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SU M M A RYThe aim of this study was to investigate the prognostic significance of troponin I, C-reactive protein and risk factors for the occurrence of complications after myocardial infarction.Troponin I and C-reactive protein values were analyzed in 38% of patients with complications (postinfarction angina, ventricular fibrillation, heart failure and fatal outcome) and in 62% of patients without complications. Values wererecorded on admission and between the eighth and tenth day of hospitalization.It was found that a larger number of risk factors (p = 0.00), diabetes mellitus (p = 0.02) and smoking (p = 0.01) were significantly associated with the complications. It was shown that hypertension increases the risk of developing heart failure after acute myocardial infarction (p = 0.02). It resulted with statistically non-significant difference in the observed values of troponin I between the group of patients with complications and the group without them (p = 0.22, p = 0.327).There was a statistically significant difference in the observed values of Creactive protein in the two groups of patients (p = 0.00, p = 0.01).It can be concluded that the values of troponin I had no prognostic significance in risk stratification, while the values of C-reactive protein, individual risk factors and a large numberof risk factors hadsignificance in risk stratification after myocardial infarction. Key words: myocardial infarction, troponin I, C-reactive protein, risk factors

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Section: Discussionsupporting

confidence: 90%

Troponin and C-reactive Protein in Risk Stratification after Myocardial Infarction

Hodžić¹,

Hasković²,

Duraković³

et al. 2017

Acta Facultatis Medicae Naissensis

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“…The present study demonstrated a statistically significant difference in mean hs-CRP concentrations among patients with different Killip classes (0.62 mg/dl in Killip class I vs. 0.98 mg/ml in Killip class IV; P<0.05). This finding also supports an earlier study by Suleiman et al (19), in which it was reported that patients with acute MI had CRP levels in the upper quartile, were older, had higher baseline creatinine levels and had a greater history of heart failure.…”

Section: Hs-crp (Mg/dl) Hs-trop T (Ng/ml) ---------------------------supporting

confidence: 91%

Clinical and angiographic correlation of high-sensitivity C-reactive protein with acute ST elevation myocardial infarction

Tanveer

Banu

Jabir

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Vascular inflammation and associated ongoing inflammatory responses are considered as the critical culprits in the pathogenesis of acute atherothrombotic events such as acute coronary syndrome (ACS) and myocardial infarction (MI). ST segment elevation myocardial infarction (STEMI) is considered as one of the prominent clinical forms of ACS. Moreover, C-reactive protein (CRP) is an important acute phase prsotein, which may be estimated using high-sensitivity methods (hs-CRP), and its elevated level in body fluids reflects chronic inflammatory status. The circulating hs-CRP level has been proposed as a promising inflammatory marker of coronary artery disease (CAD). The present study investigated the correlation of hs-CRP level with clinical and angiographic features of STEMI, various other traditional risk factors, complications of myocardial infarction and angiographically significant CAD. Out of 190 patients with STEMI that were analyzed, the interval between symptom onset and reperfusion therapy (window period) varied from 0.5 to 24 h. The hs-CRP value was found to be higher in non-diabetic patients (0.61 mg/dl) compared with diabetic patients (0.87 mg/dl). Moreover, a significant correlation between hs-CRP and hs-troponin T was also recorded (P<0.001). However, there was no significant difference in the mean hs-CRP values in patients with or without mortality. It is considered that the present study will increase the understanding of atherosclerosis in general and may also have clinical applications in the targeting of therapy for this harmful disease.

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“…According to a study published by Bonvini et al, inflammatory response following an acute myocardial infarction should CRP is an acute-phase protein synthetized by hepatocytes under the control of inflammatory cytokines and particular intrerleukin 6, and is released into the circulation in response to inflammation and tissue damage. Given that the circulating level of CRP, considered currently considered to represent a "golden marker for inflammation", reflects the severity of inflammatory response and plays a significant role in the development of atherosclerosis, many studies have attempted to predict the future cardiovascular events and the response to therapy based on CRP-based risk classification (14,15). It has been proved that high levels of circulating CRP upon admission correlates with the extent of the infarction, the development of postinfarction heart failure and the presence of severe lesion by angiography, while in patients undergoing primary PCI, high CRP level before the procedure predicted the rate of early complications (16,17).…”

Section: Discussionmentioning

confidence: 99%

Correlations between severity of coronary atherosclerosis and persistent elevation of circulating C-reactive protein levels 30 days after an acute myocardial infarction

Benedek¹,

Beáta²,

Suciu³

et al. 2014

Romanian Review of Laboratory Medicine

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Early Inflammation and Risk of Long-Term Development of Heart Failure and Mortality in Survivors of Acute Myocardial Infarction

Abstract: C-reactive-protein is a marker of long-term development of HF and mortality in patients with acute MI and provides prognostic information beyond that provided by conventional risk factors and the degree of left ventricular systolic dysfunction.

Cited by 240 publications

References 37 publications

Troponin and C-reactive Protein in Risk Stratification after Myocardial Infarction

Troponin and C-reactive Protein in Risk Stratification after Myocardial Infarction

Clinical and angiographic correlation of high-sensitivity C-reactive protein with acute ST elevation myocardial infarction

Correlations between severity of coronary atherosclerosis and persistent elevation of circulating C-reactive protein levels 30 days after an acute myocardial infarction

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