Early inspired oxygen and intermittent hypoxemic events in extremely premature infants are associated with asthma medication use at 2 years of age

Fiore, Juliann M. Di; Dylag, Andrew M.; Honomichl, Ryan; Hibbs, Anna Maria; Martin, Richard J.; Tatsuoka, Curtis; Raffay, Thomas M.

doi:10.1038/s41372-018-0264-y

Cited by 38 publications

(35 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been found that preterm infants with GA < 28 weeks of age are exposed to oxygen during the rst 3 days of life or frequent episodes of hypoxemia, which increased the risk of wheezing in children [32].…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Early Wheezing in Preterm Infants: A Retrospective Cohort Study

Chen

Yang²,

Huang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The related factors that cause recurrent wheezing in children are complex, and premature delivery may be one of the reasons. Little is known about early wheezing in preterm infants. Methods: Data sourced from 1616 children born between 2007 and 2013 from 8 hospitals of Guangxi in China. All children were followed by telephone or questionnaire through the sixth year of life. Children were grouped by characters of age: Group A: gestational age (GA) ≤ 32 weeks, Group B: 32 weeks < GA < 37 weeks, Group C: 37 weeks ≤ GA < 42 weeks. Results: The incidence and the risk factors of early wheezing in preterm infants were analyzed. The incidence of early wheezing: Group A > Group B > Group C. In Group A, the proportion of small-for-gestational-age (SGA) infant was higher in early wheezing group than in normal group (P = 0.005). Male (95% CI: 1.611 to 4.601) and family history of allergy (95% CI: 1.222 to 3.411) were the risk factors for early wheezing in Group B. Conclusions: Newborns with younger GA had a higher risk of early wheezing. SGA was a possible factor influencing early wheezing in preterm infants with GA≤ 32 weeks. Male and family history of allergy were the risk factors for early wheezing in preterm infants with 32 weeks < GA < 37 weeks.

show abstract

Section: Discussionmentioning

confidence: 99%

Risk Factors for Early Wheezing in Preterm Infants: A Retrospective Cohort Study

Chen

Yang²,

Huang

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…While the use of mechanical ventilation plays a role in respiratory support, it might cause lung injury, leading to wheezing in children with bronchopulmonary dysplasia [31]. It has been found that preterm infants with a GA< 28 weeks are exposed to oxygen during the rst 3 days of life or have frequent episodes of hypoxemia, which increases the risk of wheezing in children [32]. Although the rates of invasive mechanical ventilation use among preterm infants with a GA ≤ 32 weeks and a GA >32 but < 37 weeks was higher than that among infants in the non-wheezing group in this study, but this difference was not statistically signi cant.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for early wheezing in preterm infants: a retrospective cohort study

Chen

Yang²,

Huang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The factors that cause recurrent wheezing in children are complex, and premature delivery may be one of these factors. Little is known about early wheezing in preterm infants.Methods: Data were sourced from 1616 children born between 2007 and 2013 from 8 hospitals in Guangxi, China. All children were followed up by telephone or questionnaire through the sixth year of life. Children were grouped by gestational age (GA): Group A, GA ≤ 32 weeks; Group B, 32 weeks < GA < 37 weeks; and Group C, 37 weeks ≤ GA < 42 weeks.Results: The incidences and risk factors for early wheezing in preterm infants were analysed. The incidences of early wheezing were as follows: Group A > Group B > Group C. The incidence of persistent early wheezing in Group A or Group B was significantly higher than that in Group C, respectively. SGA (95% CI: 1.097 to 7.519) was a risk factor for early wheezing in group A. Male sex (95% CI: 1.595 to 4.501) and family history of allergies (95% CI: 1.207 to 3.352) were risk factors for early wheezing in group B.Conclusions: 1. New-borns with younger GAs had a higher risk of early wheezing. 2. The incidence of persistent early wheezing for preterm infants (GA ≤ 32 weeks and 32 weeks < GA < 37 weeks) was higher than that for full-term infants (37 weeks ≤ GA < 42 weeks). 3. SGA was a risk factor for early wheezing in preterm infants with a GA ≤ 32 weeks. 4. Male sex, personal history of allergies and family history of allergies were all possible factors affecting early wheezing in preterm infants with a GA > 32 weeks but < 37 weeks and full-term infants. Among them, male sex and family history of allergies were risk factors for early wheezing. 5. Mode of delivery, passive smoking, breastfeeding and invasive mechanical ventilation were not possible risk factors for early wheezing in infants of different GAs.

show abstract

“…1,2 Rehospitalization for respiratory illness and exacerbations during the first year of age are common and are a substantial cost to the health care system. 33 Extremely premature infants with and without BPD are at high risk for wheezing disorders with relatively high use of prescription asthma medications at 2 years of age 6 and reports of persistent flow limitations and respiratory symptoms in school-aged children. 4,5 Tracheomalacia is increasingly appreciated to be another major complication of preterm birth that is almost universally associated with BPD.…”

Section: Discussionmentioning

confidence: 99%

“…These infants are at high risk of developing later obstructive lung disease . As such, BPD patients often have bronchospastic wheezing and severe expiratory airflow obstruction requiring treatment with asthma medications . Although, bronchodilators are commonly used in this high‐risk population, there is minimal evidence for their efficacy in the treatment or prevention of BPD .…”

Section: Introduction/backgroundmentioning

confidence: 99%

“…1,2,4,5 As such, BPD patients often have bronchospastic wheezing and severe expiratory airflow obstruction requiring treatment with asthma medications. 1,2,[5][6][7][8] Although, bronchodilators are commonly used in this high-risk population, there is minimal evidence for their efficacy in the treatment or prevention of BPD. 9,10 Indeed, some BPD patients may develop tolerance 11 or even have a paradoxical response to bronchodilators, 2,8,12 likely due to underlying large airway malacia and collapse.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Tracheomalacia in bronchopulmonary dysplasia: Trachealis hyper‐relaxant responses to S‐nitrosoglutathione in a hyperoxic murine model

Einisman

Gaston

Wijers

et al. 2019

Pediatric Pulmonology

Self Cite

View full text Add to dashboard Cite

Background Bronchopulmonary dysplasia (BPD) with airway hyperreactivity is a long‐term pulmonary complication of prematurity. The endogenous nonadrenergic, noncholinergic signaling molecule, S‐nitrosoglutathione (GSNO) and its catabolism by GSNO reductase (GSNOR) modulate airway reactivity. Tracheomalacia is a major, underinvestigated complication of BPD. We studied trachealis, left main bronchus (LB), and intrapulmonary bronchiolar (IPB) relaxant responses to GSNO in a murine hyperoxic BPD model. Methods Wild‐type (WT) or GSNOR knockout (KO) newborn mice were raised in 60% (BPD) or 21% (control) oxygen during the first 3 weeks of life. After room air recovery, adult trachealis, LB, and IPB smooth muscle relaxant responses to GSNO (after methacholine preconstriction) were studied using wire myographs. Studies were repeated after GSNOR inhibitor (GSNORi) pretreatment and in KO mice. Results GSNO relaxed all airway preparations. GSNO relaxed WT BPD trachealis substantially more than WT controls (P < .05). Pharmacologic or genetic ablation of GSNOR abolished the exaggerated BPD tracheal relaxation to GSNO and also augmented BPD IPB relaxation to GSNO. LB ring contractility was not significantly different between groups or conditions. Additionally, GSNORi treatment induced relaxation of WT IPBs but not trachealis or LB. Conclusion GSNO dramatically relaxed the trachealis in our BPD model, an effect paradoxically reversed by loss of GSNOR. Conversely, GSNOR inhibition augmented IBP relaxation. These data suggest that GSNOR inhibition could benefit both the BPD trachealis and distal airways, restoring relaxant responses to those of room air controls. Because therapeutic options are limited in this high‐risk population, future studies of GSNOR inhibition are needed.

show abstract

Early inspired oxygen and intermittent hypoxemic events in extremely premature infants are associated with asthma medication use at 2 years of age

Cited by 38 publications

References 50 publications

Risk Factors for Early Wheezing in Preterm Infants: A Retrospective Cohort Study

Risk Factors for Early Wheezing in Preterm Infants: A Retrospective Cohort Study

Risk factors for early wheezing in preterm infants: a retrospective cohort study

Tracheomalacia in bronchopulmonary dysplasia: Trachealis hyper‐relaxant responses to S‐nitrosoglutathione in a hyperoxic murine model

Contact Info

Product

Resources

About