Early Intervention Improves Clinical Responses to House Dust Mite Immunotherapy in Allergic Rhinitis Patients

Qi, Shanshan; Chen, Hao; Huang, Nan; Li, Wenjing; Liu, Guanghui; Wang, Yin; Hu, Lifen; Wang, Xiaolong; Zhang, Wei; Zhu, Rongfei

doi:10.1159/000452333

Cited by 23 publications

(17 citation statements)

References 23 publications

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“…The symptoms and medication use were significantly improved after 1 year of AIT with the 2 HDM extracts. The efficacy of AIT could be observed at 3 months and the CSMS scores decreased consecutively at 6, 9, and 12 months, which was consistent with previous studies . Our study implied that the subcutaneous immunotherapy had an early effect on AR symptoms.…”

Section: Discussionsupporting

confidence: 91%

“…Sample size was calculated using non‐inferiority test with a 1‐sided 0.05 significance level and a 13% delta. The effective percentage of Alutard SQ and NHD HDM CSMS reduction was 69.7% and 71.3% in previous studies; it was calculated that 196 patients (98 per group) were required to achieve a power of 80%.…”

Section: Methodsmentioning

confidence: 91%

“…In China, only 2 commercial HDM extracts are available for subcutaneous immunotherapy, Dp extracts (Alutard SQ) provided by ALK (Hørsholm, Denmark), and Dp/Df ( 50/50 ) extracts (NovoHelisen Depot [NHD]) provided by Allergopharma (Reinbek, Germany). The 2 HDM extracts have been demonstrated to be effective in AR treatment through a series of randomized controlled studies and real‐life studies, respectively . Because the ingredients of the 2 HDM extracts are different, doctors may be curious about which product will be of greater benefit for their patients.…”

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confidence: 99%

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The efficacy and safety of two commercial house dust mite extracts for allergic rhinitis: a head‐to‐head study

Yang

et al. 2019

Int Forum Allergy Rhinol

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Background: Several studies have demonstrated the efficacy of house dust mite (HDM) immunotherapy in allergic rhinitis (AR). We aimed to compare the efficacy and safety of 2 commercial HDM extracts in a Chinese AR population. Methods:This was an open-label study. HDM-associated AR patients were randomized into Dermatophagoides pteronyssinus (Dp) extracts (Alutard SQ; ALK, Hørsholm, Denmark) and Dp/Dermatophagoides farinae (Df) extracts (NovoHelisen Depot [NHD]; Allergopharma, Reinbek, Germany) groups. All patients received subcutaneous injections for 1 year, and were followed every 3 months during that 1-year period. Symptom score, medication score, and adverse reactions were recorded. The primary endpoint was the total combined symptom and medication score (CSMS) during the efficacy evaluation period. Blood samples were taken for specific immunoglobulin E (IgE), IgG4, and IgE-blocking factor tests at baseline and a er the 1-year treatment.Results: A total of 230 AR patients were randomized; 29 patients dropped out. Analysis of the primary endpoint demonstrated significant reductions in CSMS of 1.8 vs 3.1 (p < 0.001) in the Alutard group and 1.8 vs 3.3 (p < 0.001) in the NHD group compared with baseline. The 2 groups presented equal effectiveness with regard to CSMS, symptom score, and medication score (p > 0.05). The treatment was well tolerated in both groups; 17 (14.8%) patients experienced systemic reactions (SRs) in the Alutard group and 13 (11.3%) in the NHD group. The rates of SRs showed no difference in the 2 groups (p > 0.05), and no anaphylaxis occurred. IgG4 and IgE-blocking factor to Dp and Df were increased significantly in both groups a er the 1-year treatment. Conclusion:Our study confirmed the equal efficacy and safety profile of both commercial extracts in HDMassociated AR patients. C 2019 ARS-AAOA, LLC. et al. The efficacy and safety of two commercial house dust mite extracts for allergic rhinitis: a head-to-head study. Int Forum Allergy Rhinol. 2019;9:876-882.

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Section: Discussionsupporting

confidence: 91%

Section: Methodsmentioning

confidence: 91%

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confidence: 99%

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The efficacy and safety of two commercial house dust mite extracts for allergic rhinitis: a head‐to‐head study

Yang

et al. 2019

Int Forum Allergy Rhinol

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“…Allergic rhinitis (AR) is the most common allergic disease and affects 10-40% of the population worldwide [1]. In China, self-reported AR in the general adult population significantly increased over a 6-year period [2].…”

Section: Introductionmentioning

confidence: 99%

Eight Aeroallergen Skin Extracts May Be the Optimal Panel for Allergic Rhinitis Patients in Central China

Wang

et al. 2017

Int Arch Allergy Immunol

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Background: The prevalence of allergic rhinitis (AR) is increasing rapidly in Central China. The skin prick test (SPT) is the standard tool with which to determine the allergen sensitization status in AR patients. Changes in allergen sensitization patterns have been observed within countries and regions due to geographical and seasonal variations. Objective: The aim of this study was to evaluate the profile of SPT reactivity to different aeroallergens in AR patients and to suggest a minimal panel of allergens to detect sensitized patients in Central China. Methods: From January 2015 to December 2016, patients who presented to Tongji Hospital with suspected AR were tested with the same panel of 19 aeroallergens. The results of SPT were analyzed to determine the minimum test battery panel necessary to cover 99% of the cases of SPT sensitization in different age subgroups. Results: A total of 2,416 patients (male:female ratio 1.2:1) were enrolled in our study with an average age of 22.0 years. The overall rate of sensitization to any allergen was 79.0%, and 64.3% of the subjects were monosensitized. The highest sensitized rate was found in the subgroup aged 14-18 years (92.0%), followed by the subgroups of 6-14 years (86.4%), >18 years (75.6%), and ≤6 years (74.9%). The most common sensitization was to Dermatophagoides farinae (71.1%). Testing with 8 allergens (D. pteronyssinus, D. farinae, Platanus, Artemisia, Cryptomeria, Blatella germanica, Humulus, and Alternaria) was sufficient to identify over 99% of the sensitized patients. Conclusion: An SPT panel covering 8 allergen extracts was able to detect almost all sensitized patients suffering from AR symptoms in Central China.

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“…Another study showed that the concentration of HDM allergens in the bedroom during early life is significantly associated with sensitization to HDM allergens [4]. Importantly, early intervention by allergen-specific immunotherapy significantly improved the clinical response to HDM allergens in a nonrandomized open study [5]. These reports suggest that the avoidance of airborne allergens achieved by controlling the local environment and optimal treatment during early life may be important in preventing future allergen sensitization and the crisis of allergic asthma.…”

Section: Introductionmentioning

confidence: 99%

Plasma Cluster Ions Reduce the IgE-Binding Capacity of House Dust Mite Allergens under a Simulated Indoor Environmental Condition

Okano

Fujimura²,

Fukuoka³

et al. 2017

Int Arch Allergy Immunol

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Background: A high level of house dust mite (HDM) allergens in a living environment is a risk factor for both sensitization to these allergens and asthmatic attacks. We previously showed that plasma cluster ions (PCIs) impaired the IgE-binding capacity of atomized crude allergens prepared from Japanese cedar pollen and fungus under experimental conditions. Objective: We evaluated the capacity of PCIs to impair the IgE-binding capacity of airborne HDM allergens under a simulated indoor environmental condition. Methods: For the determination of the effects of PCIs on HDM allergens under an experimental condition, HDM extract was atomized as aqueous mist into a cylindrical experimental apparatus filled with PCIs. For the evaluation of the effects of PCIs under a simulated natural indoor environmental condition, dried HDM allergens were floated as airborne particles in an acryl cubic apparatus in the presence of PCIs. The IgE-binding capacities of the PCI- and sham-treated HDM allergens were analyzed by an ELISA. Results: The IgE-binding capacity of the HDM allergens was significantly impaired after PCI treatment compared to that after sham treatment under both experimental and simulated environmental conditions. The ELISA results demonstrated that the IgE-binding capacities of HDM allergens after PCI treatment showed 68 and 74% reductions compared to those after sham treatment under the experimental and simulated environmental conditions, respectively. Conclusions: PCIs have the capacity to impair the IgE-binding capacity of airborne HDM allergens in a simulated environmental condition.

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Early Intervention Improves Clinical Responses to House Dust Mite Immunotherapy in Allergic Rhinitis Patients

Cited by 23 publications

References 23 publications

The efficacy and safety of two commercial house dust mite extracts for allergic rhinitis: a head‐to‐head study

The efficacy and safety of two commercial house dust mite extracts for allergic rhinitis: a head‐to‐head study

Eight Aeroallergen Skin Extracts May Be the Optimal Panel for Allergic Rhinitis Patients in Central China

Plasma Cluster Ions Reduce the IgE-Binding Capacity of House Dust Mite Allergens under a Simulated Indoor Environmental Condition

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