Early Intervention of Gastrodin Improved Motor Learning in Diabetic Rats Through Ameliorating Vascular Dysfunction

Zhang, Fan; Deng, Cheng-Kun; Huang, Yongjie; Miao, Yi-He; Wang, Yao-Yi; Zhang, Ying; Qian, Zhong‐Yi; Zhang, Weiquan; Zhou, Ruidong; Bao, Lei; Shen, Xin; Wu, Xingyan; Ge, Cui; Song, Jingling; Mu, Zhihao; Zou, Yongchao

doi:10.1007/s11064-020-03039-6

Cited by 17 publications

(10 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to hypertension, atherosclerosis is also a risk factor for cardiovascular and cerebrovascular diseases and for VaD. Gastrodin can restore lysosome function and autophagy activity, thereby reducing lipid accumulation and preventing foam cell formation [ 37 ]. In addition to reducing the accumulation of foam cells, GAS can also inhibit the proliferation of vascular smooth muscle cells (VSMC), regulate the effect of vascular smooth muscle, and promote angiogenesis [ 38 – 40 ].…”

Section: Resultsmentioning

confidence: 99%

Gastrodin and Vascular Dementia: Advances and Current Perspectives

Deng

Chen

Meng

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Gastrodia elata, a traditional Chinese medicine, has been widely used since ancient times to treat diseases such as dizziness, epilepsy, stroke, and memory loss. Gastrodin, one of the active components of Gastrodia elata, has been used in the treatment of migraine, epilepsy, Parkinson’s disease, dementia, and depression in recent years. It can improve cognitive function and related neuropsychiatric symptoms through various effects and is considered as a promising treatment for dementia. Vascular dementia is a kind of severe cognitive impairment syndrome caused by vascular factors, and it is the dementia syndrome with the largest number of patients besides Alzheimer’s disease. Although there is still a lack of evidence-based explorations, the paper reviewed the mechanism and methods of gastrodin in the treatment of vascular dementia, providing a reference for clinical therapy.

show abstract

Section: Resultsmentioning

confidence: 99%

Gastrodin and Vascular Dementia: Advances and Current Perspectives

Deng

Chen

Meng

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Studies have shown that gastrodin can inhibit the apoptosis of microvascular endothelial cells, reduce the infarct area, increase the formation of capillaries [ 48 ], and induce neuroprotection in mice with ischemic stroke [ 49 ]. In addition, early treatment with gastrodin can enhance the protein expression of VEGF in rats with motor learning disabilities to improve their cognitive function [ 50 ]. Panax ginseng has shown particular efficacy in the clinical treatment of certain diseases, such as dementia, diabetes, and respiratory infections [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Traditional Chinese Medicine Shenmayizhi Decoction Ameliorates Memory and Cognitive Impairment Induced by Multiple Cerebral Infarctions

Sun

Liu

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

This study aimed to illustrate the mechanism by which Shenmayizhi decoction (SMYZD) improves the learning memory of rats with vascular cognitive impairment (VCI). Fifty male and female Wistar rats of specific pathogen-free grade (SPF grade) were used to establish the model by the administration of a microsphere embolization. This was accomplished by injecting sterile, standardized, mass-produced microspheres of uniform particle size (100–200 µm in diameter) in a sodium alginate microsphere vascular embolic agent suspension to induce VCI. The VCI model was successfully established in 40 rats, including both male and female rats, and the rats were randomly divided into 4 groups of 10 rats each. The model group was administered an equal volume of distilled water. The donepezil group was administered 0.45 mg/kg/d donepezil, which is equivalent to the clinical dosage. The SMYZ-H group was administered 11.88 g/kg/d SMYZ, which is 4 times higher than the clinically equivalent dosage. The SMYZ-L group was administered 2.97 g/kg/d SMYZ, which is the clinically equivalent dosage. A sham-operated group was used as the control group and administered an equal volume of distilled water. The rats in the 4 groups were treated by gavage with equal volumes of liquid and the indicated concentration of drug diluted in distilled water for 8 consecutive weeks. Two months later, the Morris water maze (MWM) was used to evaluate the spatial memory of all the rats. Ultrastructural and ultrapathological changes in the capillaries of the cerebral cortex were observed by transmission electron microscopy. Furthermore, Western blot and RT-PCR analyses were used to assess the levels of platelet-derived growth factor receptor-β (PDGFR-β), neuron-glial antigen 2 (NG2), vascular endothelial growth factor A (VEGF-A), and angiopoietin 1 (Ang1) in the cerebral cortex of the rats. The results showed that SMYZD at concentrations of 11.88 g/kg/d and 2.97 g/kg/d (SMYZ-H and SMYZ-L) significantly shortened the escape latency (EL). In addition, SMYZ-H significantly prolonged the distance traveled and the time spent in the original platform quadrant by the rats with VCI. SMYZ-H significantly increased the NG2 and Ang1 protein expression levels and increased the PDGFR-β and Ang1 mRNA levels. These results demonstrated that Shenmayizhi decoction can improve the memory abilities of rats with VCI induced by multiple cerebral infarctions by preventing pericyte degeneration.

show abstract

“…Animals 120 adult male Sprague-Dawley rats (Liaoning Changsheng Biotechnology, Liaoning, China) were randomly divided into 4 groups: NC9w (normal control, n=20); DM9w+S group (diabetes mellitus for 9 weeks, n=40); DM9w+G60 group (diabetes mellitus for 9 weeks combined with gastric administration of Gastrodin 60mg/kg/d for 6 weeks, n=30); DM9w+G120 group (diabetes mellitus for 9 weeks combined with gastric administration of Gastrodin 120mg/kg/d for 6 weeks, n=30). Type 1 diabetes was induced by a single intraperitoneal injection of streptozotocin (65 mg/kg), while control rats received the same volume of citrate buffer [10].…”

Section: Methodsmentioning

confidence: 99%

“…Gastrodin is a phenolphthalein compound and the main active ingredient of Gastrodia elata, whose therapeutical effects on central nervous system diseases has been frequently reported recently [8]. It works through regulating neurotransmitters [9], restoring vascular function [10], anti-oxidation and anti-in ammatory effects [11]. Since there is no effective treatment of CID, we aim to test the effects of Gastrodin on protecting hippocampal neurons and improving cognitive function in diabetes.…”

Section: Introductionmentioning

confidence: 99%

Effect of Gastrodin on Cognitive Dysfunction in Diabetes by Inhibiting PAK2 Phosphorylation

Zhao

Yang

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Diabetes and cognitive dysfunction are highly prevalent disorders, while the underlying mechanism is still elusive. The effects of Gastrodin on central nervous system have been emphasized recently. In this study, we aim to explore the potential mechanism leading to cognitive dysfunction in diabetes and the therapeutic effect of Gastrodin. Diabetes was induced by a single injection of streptozotocin. RNA sequencing technique was used to identify the potential factors involved. Western blot and immunofluorescence were applied to detect the protein expression. Our results have shown that spatial learning was impaired and hippocampal pyramidal neurons were damaged in diabetic rats, which could be ameliorated by Gastrodin intervention. Transcriptional analysis identified differential expression genes, which were confirmed by qPCR and western blot. Furthermore, p21 activated kinase 2 (PAK2) was selected and its inhibitor could promote the survival of primary hippocampal neurons. It suggested that PAK2 pathway may be involved in cognitive dysfunction in diabetes and a therapeutic target for Gastrodin intervention.

show abstract

Early Intervention of Gastrodin Improved Motor Learning in Diabetic Rats Through Ameliorating Vascular Dysfunction

Cited by 17 publications

References 45 publications

Gastrodin and Vascular Dementia: Advances and Current Perspectives

Gastrodin and Vascular Dementia: Advances and Current Perspectives

Traditional Chinese Medicine Shenmayizhi Decoction Ameliorates Memory and Cognitive Impairment Induced by Multiple Cerebral Infarctions

Effect of Gastrodin on Cognitive Dysfunction in Diabetes by Inhibiting PAK2 Phosphorylation

Contact Info

Product

Resources

About