Early introduction of fish decreases the risk of eczema in infants

Alm, Bernt; Åberg, Nils; Erdes, Laslo; Möllborg, Per; Pettersson, Robert; Norvenius, SG; Goksör, Emma; Wennergren, Göran

doi:10.1136/adc.2008.140418

Cited by 127 publications

(134 citation statements)

References 35 publications

Supporting

Mentioning

116

Contrasting

Unclassified

Order By: Relevance

“…The protective effect of growing up on a small, family-owned dairy farm is in line with previous studies [2,4,36]. Recent randomized trials point to postponement of introduction of solid foods as a strong risk factor for development of food allergy [15,16] and several observational studies have pointed to delayed introduction of fish as predictive of high risk of becoming allergic [22–29]. To the best of our knowledge, practices of introducing complementary foods have not been investigated previously in children of farming families.…”

Section: Discussionsupporting

confidence: 82%

“…As mentioned above, early introduction of fish has been associated in several studies with a reduced risk of allergy development [22–29]. Our most robust finding was, however, a lower rate of allergy in children that had consumed eggs at 10 months of age or earlier, compared to children who received eggs later than 10 months of age.…”

Section: Discussionsupporting

confidence: 52%

“…not only food allergy [19–21]. In particular, delayed introduction of fish has repeatedly been associated with a higher risk of developing different atopic diseases [22–29]. Accordingly, in the FARMFLORA birth cohort we found an inverse relationship between the proportions of the fish fatty acid eicosapentaenoic acid (EPA) in the sera of four-month-old infants and the risk of subsequent allergy development [30].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Late introduction of fish and eggs is associated with increased risk of allergy development – results from the FARMFLORA birth cohort

Jönsson

Barman

Brekke

et al. 2017

Food & Nutrition Research

View full text Add to dashboard Cite

The prevalence of allergy is markedly low in children growing up on farms. An increasing number of studies indicate that the timing of food introduction may affect allergy development. We aimed to investigate if protection against allergy in farm environments may be mediated through differences in food-introduction practices between farm and non-farm families, using an explorative approach. Twenty-eight farm and 37 non-farm children were included in the FARMFLORA birth cohort. Practices of breastfeeding and introduction of formulas and complementary foods were collected by questionnaires at 6, 12, and 18 months of age. Allergy was diagnosed by pediatricians at 3 years of age. The only difference in food-introduction practices observed between farm and non-farm children was an earlier introduction of nuts in farmers (median month: 11 [IQR: 8–6] in farmers, 15 [12–19] in non-farmers). One farm child (4%) and 10 non-farm children (27%) were allergic at 3 years of age. Lower risk of allergy development was associated with early exclusive breastfeeding (continuous variable; OR = 0.59, 95% CI: 0.39–0.89), but also having received eggs (OR = 0.08, 95% CI: 0.13–0.54) and fish (logistic regression not applicable, P = 0.01 in likelihood ratio testing [χ2]) at 10 months of age or earlier compared to later. Our results were not affected by reverse causation, as judged by a questionnaire sent to the families in retrospect. Timing of introduction of complementary foods is unlikely to contribute to the lower risk of allergy among farm children. Although early exclusive breastfeeding was associated with a lower rate of allergy development, postponed introduction of complementary foods might increase the risk of developing allergy. Owing to the limited sample size, our results are only indicative, but support prior findings.

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Late introduction of fish and eggs is associated with increased risk of allergy development – results from the FARMFLORA birth cohort

Jönsson

Barman

Brekke

et al. 2017

Food & Nutrition Research

View full text Add to dashboard Cite

show abstract

“…4 The updated 2014 RBR recommendation is based on a growing body of evidence that supports early and continuous exposure to allergenic foods, including peanut, as a means of allergy prevention. 4,5 The prevalence of peanut allergy is known to be I highest in some Westernized countries such as the UK, USA, Canada, and Australia (around 1-2%), and lowest in Asian countries where peanut is not on the list of common allergens in children. 6 The overall rate of atopic disease in developed and underdeveloped countries is rising, with food allergy being strongly associated with other atopic disorders.…”

mentioning

confidence: 99%

“…6 The overall rate of atopic disease in developed and underdeveloped countries is rising, with food allergy being strongly associated with other atopic disorders. [5][6][7] In developed countries, about 50% of children with a food allergy have atopic dermatitis, 40% have asthma, and about 30% have allergic rhinitis. 5,7 In the context of rising rates of atopic disease and emerging evidence on allergy prevention, it is important for clinicians to understand the clinical implications of these changing guidelines.…”

mentioning

confidence: 99%

Peanut allergy prevention: Current evidence and implications for clinical practice

Allen

2017

DMJ

View full text Add to dashboard Cite

In the last decade there has been a major shift in clinical practice guidelines from the avoidance of allergenic foods for the purpose of preventing allergy development toward their early introduction before six months of age. The purpose of this article is to review current evidence for this change in recommendation and to evaluate its implications for clinical practice. A literature review and analysis were conducted focusing on key clinical studies that influenced this change in practice over the past decade. The main findings supported the early introduction of peanut to the diet and highlighted two areas of uncertainty in the literature that have implications for adopting the new guidelines in clinical practice. First, current evidence lacks a clear definition of "high risk" for determining allergic predisposition in infants; and second, defining the ideal timing, amount, and frequency with which peanut and peanut containing foods are introduced into a child's diet is not yet established in the literature. The principal conclusion underscored the importance of early and continual exposure to peanut regardless of risk of atopy.

show abstract

Atopic Eczema (Atopic Dermatitis)

Ardern‐Jones

2016

Rook's Textbook of Dermatology, Ninth Edition

View full text Add to dashboard Cite

Atopic eczema is a chronic, relapsing, inflammatory skin condition characterized by itch which affects 20–30% of schoolchildren and 5–10% of adults in the UK. The increased prevalence in both western industrialized countries and developing nations over the last 20 years highlights the strong role of environmental factors in mediating the disease. However, the identification of a strong association between atopic eczema and mutations in the gene encoding filaggrin in 2006 has provided a paradigm shift in our understanding of the role of genetics in this condition and the importance of the function of the epidermal barrier. Indeed, interventions to repair the epidermal barrier show promise in both the treatment and prevention of atopic eczema and its complications. T‐helper 2 cells are central to mediating atopic eczema inflammation and specific targeted interventions are progressing well in clinical trials. Further developments in our understanding of disease pathogenesis, including the role of thymic stromal lymphopoeitin, and recently discovered subsets of immunocytes, are exciting targets and provide an optimistic future for the management of this challenging disease. However, topical therapy with emollients, corticosteroids and calcineurin inhibitors remains the mainstay of treatment. Thus, for more severe disease, current therapeutic options remain limited. As a result, atopic eczema still contributes a significant quality of life and financial burden on society and health care systems worldwide.

show abstract

Early introduction of fish decreases the risk of eczema in infants

Cited by 127 publications

References 35 publications

Late introduction of fish and eggs is associated with increased risk of allergy development – results from the FARMFLORA birth cohort

Late introduction of fish and eggs is associated with increased risk of allergy development – results from the FARMFLORA birth cohort

Peanut allergy prevention: Current evidence and implications for clinical practice

Atopic Eczema (Atopic Dermatitis)

Contact Info

Product

Resources

About