2020
DOI: 10.21203/rs.3.rs-23072/v1
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Early L-T4 Intervention Improves Fetal Heart Development in Pregnant Rats with Subclinical Hypothyroidism Rats by Activating BMP4/Smad4 Signaling Pathway

Abstract: Background: It is unclear whether the offspring of SCH pregnant rats still have abnormal cardiac development, and whether early intervention with L-T4 can improve the abnormality of these offspring. Therefore, the aim of this study was to investigate the effect of early L-T4 intervention on the heart development of offspring of SCH pregnant rats and its possible molecular mechanism.Methods: Eighty female Wistar rats were randomly divided into Sham group (placebo control), SCH group, LT4-E10 group (L-T4 treatme… Show more

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