Early Life Adversity Is Associated With Elevated Levels of Circulating Leptin, Irisin, and Decreased Levels of Adiponectin in Midlife Adults

Joung, Kyoung Eun; Park, Kyung-Hee; Zaichenko, Lesya; Sahin-Efe, Ayse; Thakkar, Bindiya; Brinkoetter, Mary; Usher, Nicole; Warner, Dorothy E.; Davis, Cynthia R.; Crowell, Judith A.; Mantzoros, Christos S.

doi:10.1210/jc.2013-3669

Cited by 60 publications

(50 citation statements)

References 19 publications

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“…A possible explanation of these findings is illustrated in a recent study by Joung et al (2014) that demonstrated how childhood adversity can place stress on the endocrine system through the dysregulation of certain hormones (i.e. leptin, adiponectin and irisin) and the inflammatory marker Creactive protein (CRP) all of which have been associated with obesity and diabetes in adulthood.…”

Section: Discussionmentioning

confidence: 99%

“…neglect, sexual and physical abuse) on disorders related to the endocrine system such as type 1 and type 2 diabetes mellitus, obesity, and metabolic diseases (Joung et al 2014; Thomas et al 2008;Widom et al 2012). A recent meta-analysis (Hemmingsson et al 2014) reported significant positive associations between the severity of childhood abuse and adult obesity.…”

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confidence: 99%

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Social, Familial and Psychological Risk Factors for Endocrine, Nutritional and Metabolic Disorders in Childhood and Early Adulthood: a Birth Cohort Study Using the Danish Registry System

et al. 2017

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Research studies have identified associations between a range of social, familial and psychological risk factor andphysicalhealth.However,therearemanymethodological limitationsinsuchstudies(e.g.self-reportedhealthstatus,retrospectiverecallofadverse events,andlack ofcontrolforpossible heritability effects). The current study seeks to assess the effect of a range of social and psychosocial risk factors on a diagnosis ofanyendocrine,nutritional,andmetabolic(ENM) disorders (ICD-10 E00-99) using linked Danish registry data fromalargebirthcohort.Datalinkage.Anationalbirthcohortof theDanishpopulationbornin1984wasusedinthecurrentstudy (n = 54,458). Psychosocial risk factors including parental history of diagnosis of an ENM disorder, advanced parental age, gender, urban dwelling, economic deprivation, family dissolutionandchildhoodadversity(childincare)wereusedtopredictanyENMdiagnosis.Bivariateassociationsshowedthatall variables,exceptadvancedpaternalage,weresignificantlyassociatedwithENMdiagnosis.Whenthevariableswereentered into a multivariate binary logistic regression analysis childhood adversity (child in care) was the strongest predictor of diagnosis (OR = 2.36) followed by maternal diagnosis of an endocrine disorder (OR = 1.74) and advanced maternal age (OR = 1.69). Results suggest that childhood adversity is the dominant factor in the prediction of an ENM diagnosis. The currentstudyextendstheliteratureconductedonadultpopulationsbydemonstratingthatearlyadverseexperiencesareassociatedwithpoororpoorerhealthoutcomesinyoungadulthood.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Social, Familial and Psychological Risk Factors for Endocrine, Nutritional and Metabolic Disorders in Childhood and Early Adulthood: a Birth Cohort Study Using the Danish Registry System

et al. 2017

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“…Ці-каві результати, що були отримані при вивченні да-них анкетування дорослих американців Kyoung Eun Joung і співавт. [8], які свідчать про те, що низька оцінка якості життя високоасоційована з розвитком абдомінального ожиріння і рівнем концентрації леп-тину, резистину, адипонектину в сироватці крові.…”

Section: резюме мета дослідження -визначення асоціації однонуклеотидunclassified

Молекулярно-Генетична Концепція Формування Психотипів Особистості В Дітей При Ожирінні, Асоційованому З Лактозною Інтолерантністю

Абатуров

Никулина

2021

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ВступПрактично у всьому світі кількість дітей, хворих на ожиріння, подвоюється кожні три десятиліття. За останні 20 років поширеність ожиріння серед дітей віком від 6 до 11 років збільшилася вдвічі (з 7 до 13 %), а серед підлітків віком від 12 до 18 років -більше ніж у 3 рази (з 5 до 17 %) [7, 11, 16]. В Україні поширеність дитячого ожиріння у 2015 році стано-вила 10,83 на 1 тис. дітей віком 0-14 років та 28,27 на Êë³í³÷íà ïåä³àòð³ÿ / Clinical Pediatrics ® 1 тис. підлітків віком 15-18 років. Первинна захво-рюваність на ожиріння у 2015 році становила 2,39 на 1 тис. дітей віком 0-14 років та 4,51 на 1 тис. підліт-ків віком 15-18 років [3].Зростаюча поширеність ожиріння і надмірної ваги серед підлітків не може бути пояснена виключ-но невідповідністю кількості енергії споживаної їжі енерговитратам макроорганізму. Ризик розви-тку ожиріння асоційований як із наявністю мутацій УДК 613.25:548.33:577.15-053.2:159.923

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“…Indeed, stress-related hormones are able to affect the functioning of metabolic hormones (Joung et al, 2014) and MS on P8 from 4 to 12 h in mice leads to reductions of circulating glucose as well as leptin levels and increases in ghrelin levels early in life (Schmidt et al, 2006). Further pointing to a key modulating role of these metabolic hormones in the programming of the HPA axis; blocking the MS-induced ghrelin increase could reverse the MS effects on the HPA axis as well.…”

Section: Role Of Metabolic Hormones In Regulating the Hypothalamic-pimentioning

confidence: 99%

Early-life adversity programs emotional functions and the neuroendocrine stress system: the contribution of nutrition, metabolic hormones and epigenetic mechanisms

Yam

Naninck

Schmidt

et al. 2015

Stress

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Clinical and pre-clinical studies have shown that early-life adversities, such as abuse or neglect, can increase the vulnerability to develop psychopathologies and cognitive decline later in life. Remarkably, the lasting consequences of stress during this sensitive period on the hypothalamic-pituitary-adrenal axis and emotional function closely resemble the long-term effects of early malnutrition and suggest a possible common pathway mediating these effects. During early-life, brain development is affected by both exogenous factors, like nutrition and maternal care as well as by endogenous modulators including stress hormones. These elements, while mostly considered for their independent actions, clearly do not act alone but rather in a synergistic manner. In order to better understand how the programming by early-life stress takes place, it is important to gain further insight into the exact interplay of these key elements, the possible common pathways as well as the underlying molecular mechanisms that mediate their effects. We here review evidence that exposure to both early-life stress and early-life under-/malnutrition similarly lead to life-long alterations on the neuroendocrine stress system and modify emotional functions. We further discuss how the different key elements of the early-life environment interact and affect one another and next suggest a possible role for the early-life adversity induced alterations in metabolic hormones and nutrient availability in shaping later stress responses and emotional function throughout life, possibly via epigenetic mechanisms. Such knowledge will help to develop intervention strategies, which gives the advantage of viewing the synergistic action of a more complete set of changes induced by early-life adversity.

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Early Life Adversity Is Associated With Elevated Levels of Circulating Leptin, Irisin, and Decreased Levels of Adiponectin in Midlife Adults

Cited by 60 publications

References 19 publications

Social, Familial and Psychological Risk Factors for Endocrine, Nutritional and Metabolic Disorders in Childhood and Early Adulthood: a Birth Cohort Study Using the Danish Registry System

Social, Familial and Psychological Risk Factors for Endocrine, Nutritional and Metabolic Disorders in Childhood and Early Adulthood: a Birth Cohort Study Using the Danish Registry System

Молекулярно-Генетична Концепція Формування Психотипів Особистості В Дітей При Ожирінні, Асоційованому З Лактозною Інтолерантністю

Early-life adversity programs emotional functions and the neuroendocrine stress system: the contribution of nutrition, metabolic hormones and epigenetic mechanisms

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