Early-life AFB1 exposure: DNA methylation and hormone alterations

Rotimi, Oluwakemi A.; Campos, Opeyemi Christianah De; Adelani, Isaacson B.; Olawole, Tolulope Dorcas; Rotimi, Solomon O.

doi:10.1016/bs.vh.2022.11.004

Cited by 4 publications

(1 citation statement)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DNA methylation is adding a methyl group to the fifth carbon atom of cytosine on DNA, producing 5-methylcytosine (5-mC) 23 . The DNA methyltransferases (DNMTs) involved in the association between digestive system tumors and ncRNAs include DNMT1, DNMT3A, and DNMT3B.…”

Section: Methyltransferasesmentioning

confidence: 99%

The bidirectional interplay between ncRNAs and methylation modifications in gastrointestinal tumors

Kong,

Yu,

Guo

et al. 2023

Int. J. Biol. Sci.

View full text Add to dashboard Cite

The aberrant expression of methylation and ncRNAs, two crucial regulators of epigenetic modifications, has been widely demonstrated in cancer. The complex interplay between them is essential in promoting malignant phenotype, poor prognosis, and drug resistance in GI tumors (including esophageal, gastric, colorectal, liver, and pancreatic cancers). Therefore, we summarize the interrelation process between ncRNAs and methylation modifications in GI tumors, including the detailed mechanism of methylation enzyme regulation of ncRNAs, the molecular mechanism of ncRNAs regulation of methylation modifications, and the correlation between the interactions between ncRNAs and methylation modifications and clinical features of tumors. Finally, we discuss the potential value of ncRNAs and methylation modifications in clinical diagnosis and therapy.

show abstract

Section: Methyltransferasesmentioning

confidence: 99%

The bidirectional interplay between ncRNAs and methylation modifications in gastrointestinal tumors

Kong,

Yu,

Guo

et al. 2023

Int. J. Biol. Sci.

View full text Add to dashboard Cite

show abstract

Exposure assessment of children to dietary mycotoxins: A pilot study conducted in Ribeirão Preto, São Paulo, Brazil

Ali,

Battaglini Franco,

Theodoro Rezende

et al. 2024

Food Research International

View full text Add to dashboard Cite

Lactobacillus intestinalis/Lactobacillus rhamnosus protects against AFB1-induced liver damage: involvement of intestinal mucosal barrier

Chen,

Liu,

et al. 2023

One Health Adv.

View full text Add to dashboard Cite

Aflatoxin B1 (AFB1) is a widely spread mycotoxin that poses a threat to the healthy to human and animals. The liver is the main target organ for AFB1-induced damage, primarily causing inflammatory injury and oxidative stress. When AFB1 enters the body, it can damage the intestinal barrier function, and its metabolites are transported to the liver. Therefore, the damage to the liver is closely associated with intestinal barrier impairment. Lactobacillus plays a crucial role in mitigating liver damage by improving the intestinal barrier function. In our previous report, we reported that Lactobacillus reduces liver damage caused by AFB1. However, it is still unclear how the intestinal barrier contributes to the protective effects of Lactobacillus against AFB1. To investigate the protective effects and intestinal barrier mechanisms of Lactobacillus intestinals /rhamnosus against AFB1-induced liver damage, we orally administered AFB1 and Lactobacillus intestinals/rhamnosus to male SD rats. Then the body weight, organ index, histopathological changes in the liver and gut, liver and kidney function indicators, intestinal mucosal barrier indicators, serum AFB1 content and inflammatory factors, liver oxidative stress index, and short-chain fatty acids content were analyzed. Our findings demonstrate that exposure to AFB1 resulted in changes in liver histopathology and biochemical functions, altered inflammatory response and oxidative stress, compromised the intestinal mucosal barrier, and induced the accumulation of inflammatory factor and inflammation in the liver. However, supplementation with Lactobacillus intestinals or Lactobacillus rhamnosus significantly prevented AFB1-induced liver injury, alleviated histopathological changes and hepatic injury by the maintenance of intestinal mucosal barrier integrity.

show abstract

Early-life AFB1 exposure: DNA methylation and hormone alterations

Cited by 4 publications

References 77 publications

The bidirectional interplay between ncRNAs and methylation modifications in gastrointestinal tumors

The bidirectional interplay between ncRNAs and methylation modifications in gastrointestinal tumors

Exposure assessment of children to dietary mycotoxins: A pilot study conducted in Ribeirão Preto, São Paulo, Brazil

Lactobacillus intestinalis/Lactobacillus rhamnosus protects against AFB1-induced liver damage: involvement of intestinal mucosal barrier

Contact Info

Product

Resources

About