Early-Life Benzo[a]Pyrene Exposure Causes Neurodegenerative Syndromes in Adult Zebrafish (Danio rerio) and the Mechanism Involved

Gao, Dongxu; Wang, Chonggang; Xi, Zhihui; Zhou, Yixi; Wang, Yuanchuan; Zuo, Zhenghong

doi:10.1093/toxsci/kfx028

Cited by 45 publications

(14 citation statements)

References 58 publications

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“…In the current study, SE mediated the impact of prenatal PAH exposure on behavioral problems. The finding that higher prenatal exposure to PAH predicted lower SE was consistent with the animal models showing the inverse relation between prenatal PAH exposure and locomotor activity (Gao et al., 2017; Suzuki et al., 2010). Other air pollutants, such as PM 2.5 and traffic‐related air pollution, have also been linked to decreased locomotion, partly due to a decrease in hippocampal brain‐derived neurotrophic factor (BDNF) expression (Zhou et al., 2020) and reduced striatal dopamine (Yokota et al., 2009), respectively.…”

Section: Discussionsupporting

confidence: 84%

“…Previous animal studies showed a decrease in dopamine and serotonin in zebrafish due to PAH exposure (Gao et al, 2017;Vignet et al, 2017). Exposure-related reductions in dopamine and serotonin might lead to increased fear (Clinton, Stead, Miller, Watson, & Akil, 2011;Gao et al, 2017) and increased frustration (de Almeida, Ferrari, Parmigiani, & Miczek, 2005). Prenatal exposures to other air pollutants (e.g.…”

Section: Discussionmentioning

confidence: 99%

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Prenatal exposure to air pollution and maternal stress predict infant individual differences in reactivity and regulation and socioemotional development

Liu

DeSerisy

Herbstman

et al. 2022

Child Psychology Psychiatry

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Background Humans are ubiquitously exposed to air pollutants including polycyclic aromatic hydrocarbons (PAH). Although most studies of prenatal exposures have focused on psychopathology in childhood or adolescence, the effects of air pollutants on early emerging individual differences in reactivity and regulation are of growing concern. Our study is the first to report effects of prenatal exposure to PAH and maternal stress on infant reactivity and regulation. Methods Participants included 153 infants (74 girls and 79 boys). Prenatal exposure to PAH was measured via personal air monitoring during the third trimester of pregnancy. Maternal perceived stress was measured via self‐report. We assessed infant orienting/regulation (OR), surgency (SE), and negative affectivity (NA) at 4 months using the Infant Behavior Questionnaire. We measured infant socioemotional outcomes at 12 months using the Brief Infant‐Toddler Social & Emotional Assessment Questionnaire. Results Infants with higher prenatal PAH exposure and of mothers with higher stress had lower OR at 4 months, which predicted lower competence at 12 months. Infants with higher prenatal PAH exposure had lower SE at 4 months, which predicted more behavioral problems at 12 months. Prenatal exposure to PAH had no effects on infant NA at 4 months, although NA was associated with greater behavioral problems at 12 months. Conclusions Infant reactivity and regulation, as early makers of child psychopathology, can facilitate timely and targeted screening and possibly prevention of disorders caused, in part, by environmental pollution. A multifaceted approach to improve environmental quality and reduce psychosocial stress is necessary to improve the developmental outcomes of children and most specially children from disadvantaged communities that disproportionately experience these environmental exposures.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Prenatal exposure to air pollution and maternal stress predict infant individual differences in reactivity and regulation and socioemotional development

Liu

DeSerisy

Herbstman

et al. 2022

Child Psychology Psychiatry

View full text Add to dashboard Cite

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“…This was unexpected and may have been due to a mechanism different from AHR2/ARNT acting via AHREs in the dnmt promoters. Another study found that, following BaP exposure, dnmt1 and dnmt3a had increased mRNA expression in 96-hpf larvae and in adult brains; however, the role of the AHRs in mediating the altered expression was not investigated (Gao et al, 2017).…”

Section: Epigenetics and Multigenerational Effectsmentioning

confidence: 99%

A Review of the Functional Roles of the Zebrafish Aryl Hydrocarbon Receptors

Shankar

Dasgupta

Hahn

et al. 2020

Toxicological Sciences

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Over the last two decades, the zebrafish (Danio rerio) has emerged as a stellar model for unraveling molecular signaling events mediated by the Aryl Hydrocarbon Receptor (AHR), an important ligand-activated receptor found in all eumetazoan animals. Zebrafish have three AHRs – AHR1a, AHR1b, and AHR2, and studies have demonstrated the diversity of both the endogenous and toxicological functions of the zebrafish AHRs. In this contemporary review, we first highlight the evolution of the zebrafish ahr genes, and the characteristics of the receptors including developmental and adult expression, their endogenous and inducible roles, and the predicted ligands from homology modeling studies. We then review the toxicity of a broad spectrum of AHR ligands across multiple life stages (early stage, and adult), discuss their transcriptomic and epigenetic mechanisms of action, and report on any known interactions between the AHRs and other signaling pathways. Through this article, we summarize the promising research that furthers our understanding of the complex AHR pathway through the extensive use of zebrafish as a model, coupled with a large array of molecular techniques. Since much of the research has focused on the functions of AHR2 during development and the mechanism of TCDD toxicity, we illustrate the need to address the considerable knowledge gap in our understanding of both the mechanistic roles of AHR1a and AHR1b, and the diverse modes of toxicity of the various AHR ligands.

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“…Due to its chemical and thermal stability as well as due to its bioaccumulation and dissolution properties, benzpyrene has mutagenic, embryotoxic, and haematotoxic impact on living beings, as it is stated at nekurim.ru. According to Gao D. et al (2017) and Rozanova E. et al (2009), benzpyrene is extremely harmful to human health. Their findings are supported by Gupta P.D.…”

Section: Figure 1: Growth Dynamics Of Pollutants Emission By Vehiclesmentioning

confidence: 99%

Energy Sources, Environment and Public Health

Грачев¹,

Kurysheva²

2019

Proceedings of the 50th International Academic Conference, Paris

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The paper discusses the issue of the impact of various energy technologies on public health since the matter is pressing due to the emergence of new ways to harness energy such as waste incineration. The study shows that coal energy, waste incineration, and transport emissions are major hazards to public health. The study reveals nuclear energy is the most environmentally efficient and has the least adverse impact on public health. The paper demonstrates that the use of waste to generate energy is extremely dangerous for public health and can cause emission of polychlorinated dibenzodioxins, which poses a serious hazard. The paper postulates it is uncertain whether waste incineration is beneficial in terms of energy, but it is dangerous for sure. According to the paper, the use of conventional motor fuels is also hazardous due to benzopyrene emissions. Therefore, it is better to use the energy harnessed at nuclear or gas power plants to fir motor vehicles.

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Early-Life Benzo[a]Pyrene Exposure Causes Neurodegenerative Syndromes in Adult Zebrafish (Danio rerio) and the Mechanism Involved

Cited by 45 publications

References 58 publications

Prenatal exposure to air pollution and maternal stress predict infant individual differences in reactivity and regulation and socioemotional development

Prenatal exposure to air pollution and maternal stress predict infant individual differences in reactivity and regulation and socioemotional development

A Review of the Functional Roles of the Zebrafish Aryl Hydrocarbon Receptors

Energy Sources, Environment and Public Health

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