Early life exposure to bisphenol A investigated in mouse models of airway allergy, food allergy and oral tolerance

Nygaard, Unni Cecilie; Vinje, N. E.; Samuelsen, Mari; Andreassen, Monica; Groeng, Else‐Carin; Bølling, Anette Kocbach; Becher, Rune; Løvik, Martinus; Bodin, Johanna

doi:10.1016/j.fct.2015.05.009

Cited by 22 publications

(22 citation statements)

References 47 publications

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“…In addition to the studies of Ménard et al (10, 11) and Bauer et al (12), the workshop participants identified three other reports published after 2012 and in which immune effects of BPA were studied in different experimental immune models (13, 15, 16). Additionally, three other studies (14, 17, 18) already evaluated by EFSA were reconsidered due to their relevance to the new studies.…”

Section: Workhop Discussion and Conclusion Of The Key Studiesmentioning

confidence: 99%

“…In addition to the Ménard et al studies (10,11), one other study investigated the effects of BPA using oral immunization and oral tolerance models (13). These studies differed with regard to the mouse strain, timing, dose, and route of exposure to BPA, the model food allergen used, the sensitization and challenge protocol performed, and the endpoints measured (Table 5).…”

Section: Workhop Discussion and Conclusion Of The Key Studiesmentioning

confidence: 99%

“…These studies differed with regard to the mouse strain, timing, dose, and route of exposure to BPA, the model food allergen used, the sensitization and challenge protocol performed, and the endpoints measured (Table 5). In the Nygaard et al, 2015 study (13), C3H/HeJ mice were exposed to BPA in their drinking water (0, 1, 10 or 100 μg/ml (lowest dose 180–340 μg/kg BW/day, see Table 5 for all corresponding calculated BPA exposure levels in this study in μg/kg BW/day) from mating until the end of the experiment. Effects of BPA exposure were studied in a food allergy model and an oral tolerance model using lupin as an allergen.…”

Section: Workhop Discussion and Conclusion Of The Key Studiesmentioning

confidence: 99%

“…The participants evaluated the design and results of the different experimental studies performed in these three publications in detail. The outcomes were put in the context of other available animal studies that identified immunotoxic effects of BPA (13–18). The workshop considerations will be represented in this report.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of recent developmental immunotoxicity studies with bisphenol A in the context of the 2015 EFSA t-TDI

Hessel

Ezendam

Broekhuizen

et al. 2016

Reproductive Toxicology

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Summary Humans are exposed to bisphenol A (BPA) mainly through the diet, air, dust, skin contact and water. There are concerns about adverse health effects in humans due to exposure to bisphenol A (BPA). The European Food Safety Authority (EFSA) has extensively reviewed the available literature to establish a temporary Tolerable Daily Intake (t-TDI). This exposure level was based on all available literature published before the end of 2012. Since then, new experimental animal studies have emerged, including those that identified effects of BPA on the immune system after developmental exposure. These studies indicate that developmental immunotoxicity might occur at lower dose levels than previously observed and on which the current EFSA t-TDI is based. The Dutch National Institute for Public Health and the Environment (RIVM) organized an expert workshop in September 2015 to consider recently published studies on the developmental immunotoxicity of bisphenol A (BPA). Key studies were discussed in the context of other experimental studies. The workshop concluded that these new experimental studies provide credible evidence for adverse immune effects after developmental exposure to BPA at 5 μg/kg BW/day from gestation day 15 to postnatal day 21. Supportive evidence for adverse immune effects in similar dose ranges was obtained from other publications that were discussed during the workshop. The dose level associated with adverse immune effects is considerably lower than the dose used by EFSA for deriving the t-TDI. The workshop unanimously concluded that the current EFSA t-TDI warrants reconsideration in the context of all currently available data.

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Section: Workhop Discussion and Conclusion Of The Key Studiesmentioning

confidence: 99%

Section: Workhop Discussion and Conclusion Of The Key Studiesmentioning

confidence: 99%

Section: Workhop Discussion and Conclusion Of The Key Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Assessment of recent developmental immunotoxicity studies with bisphenol A in the context of the 2015 EFSA t-TDI

Hessel

Ezendam

Broekhuizen

et al. 2016

Reproductive Toxicology

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show abstract

“…Recent studies have been proposed to evaluate the exposure to endocrine disruptors, such as food contaminants, heavy metals, fine particulate matter, pesticides and plastics products, during the critical phases of development and the long-term effects of this exposure on offspring metabolism [10][11][12]. Experimental and epidemiological studies have suggested that endocrine disruptor exposure during neonatal phases induces permanent metabolic dysfunction in adult offspring [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Particulate Matter Exposure During Perinatal Life Results in Impaired Glucose Metabolism in Adult Male Rat Offspring

Miranda

Franco

Previate

et al. 2018

Cell Physiol Biochem

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Background/Aims: Particulate matter (PM) is an important risk factor for immunological system imbalance due to its small size, which can reach more distal regions of the respiratory tract, independently of its chemical composition. Some studies have suggested that PM exposure is associated with an increased incidence of diabetes, especially in industrialized urban regions. However, studies regarding the effects of PM exposure during perinatal life on glucose metabolism are limited. We tested whether exposure to PM from an urban area with poor air quality during pregnancy and lactation could cause short- and long-term dysfunction in rat offspring. Methods: Samples of < 10 µm PM were collected in an urban area of Cotonou, Benin (West Africa), and reconstituted in corn oil. Pregnant Wistar rats received 50 µg PM/day by gavage until the end of lactation. After birth, we analyzed the dams’ biochemical parameters as well as those of their male offspring at 21 and 90 days of age. Results: The results showed that PM exposure did not lead to several consequences in dams; however, the male offspring of both ages presented an increase of approximately 15% in body weight. Although the blood glucose levels remained unchanged, the insulin levels were increased 2.5- and 2-fold in PM exposure groups of both ages, respectively. HOMA-IR and HOMA-β were also increased at both ages. We also demonstrated that the number, islet area and insulin immunodensity of pancreatic islets were significantly increased at both ages from PM exposure. Conclusion: Our data show that chronic PM exposure by the oral route during perinatal life in rats leads to glucose dyshomeostasis in male offspring both in early and later life. Thus, we suggest that an ambience with poor air quality, mainly where traffic is dense, can contribute to an increase in metabolic disease incidence.

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Immunotoxicology in Industrial Hygiene and Occupational Exposures

2023

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Immunotoxicology is the study of drugs and chemicals that produce adverse effects on the immune system. Adverse immune effects include suppression, leading to compromised ability to fight infections, or enhancement, which could be involved in hypersensitivity (allergy) or autoimmunity. It has been appreciated for hundreds of years that diseases are associated with various occupations, such as respiratory diseases in those working with grains, coal, metals, or animals. We now understand that many of these occupational diseases are the result of an unregulated immune response to a specific agent. Similarly, occupational exposures to various chemicals can produce dermatitis, again due in part to unregulated immune responses in the skin. Additionally, occupational chemical exposures have been demonstrated to induce immune suppression. This chapter provides an overview of the immune system, a synopsis of standard assays to evaluate immunotoxic potential of occupational chemicals, and descriptions of effects of several occupational immunotoxicants with a focus on human exposures and doses. Consideration is given to current data gaps and potential use of novel technologies to more precisely define effects and mechanisms of occupational immunotoxicants.

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Early life exposure to bisphenol A investigated in mouse models of airway allergy, food allergy and oral tolerance

Cited by 22 publications

References 47 publications

Assessment of recent developmental immunotoxicity studies with bisphenol A in the context of the 2015 EFSA t-TDI

Assessment of recent developmental immunotoxicity studies with bisphenol A in the context of the 2015 EFSA t-TDI

Particulate Matter Exposure During Perinatal Life Results in Impaired Glucose Metabolism in Adult Male Rat Offspring

Immunotoxicology in Industrial Hygiene and Occupational Exposures

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