Early life exposure to outdoor air pollution and indoor environmental factors on the development of childhood allergy from early symptoms to diseases

Lu, Chan; Liu, Zijing; Yang, Wenhui; Liao, Hongsen; Liu, Qin; Li, Qin; Deng, Qihong

doi:10.1016/j.envres.2022.114538

Environmental Research

2023

DOI: 10.1016/j.envres.2022.114538

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Early life exposure to outdoor air pollution and indoor environmental factors on the development of childhood allergy from early symptoms to diseases

Chan Lu

Zijing Liu²,

Wenhui Yang³

et al.

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Cited by 15 publications

(1 citation statement)

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“…Previous reports showed an increased risk of onset of childhood asthma associated with early-life exposure to PM. [26][27][28][29] We demonstrated that an increase in PM 10 and PM 2.5 exposure increased the duration of asthma in EOA patients. A previous study reported that PM exposure during 1 week and 2 weeks resulted in a significant increase in the risk of asthma attacks.…”

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confidence: 62%

Different Impacts of Traffic-Related Air Pollution on Early-Onset and Late-Onset Asthma

Lin,

Makrufardi,

Tung

et al. 2024

JAA

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Background Early-onset asthma (EOA) and late-onset asthma (LOA) are two distinct phenotypes. Air pollution has been associated with an increase in poorer asthma outcomes. The objective of this study was to examine the effects of traffic-related air pollution (TRAP) on asthma outcomes in EOA and LOA patients. Methods A cross-sectional study was conducted on 675 asthma patients (LOA: 415) recruited from a major medical center in Taiwan. The land-use regression (LUR) model was used to estimate the level of exposure to PM 10 , PM 2.5 , NO 2 , and O 3 on an individual level. We investigated the association between TRAP and asthma outcomes in EOA and LOA patients, stratified by allergic sensitization status, using a regression approach. Results An increase in PM 10 was associated with younger age of onset, increased asthma duration, and decreased lung function in EOA patients ( p <0.05). An increase in PM 10 was associated with older age of onset, and decreased asthma duration, eosinophil count, and Asthma Control Test (ACT) score in LOA patients. An increase in PM 2.5 was associated with younger age of onset, increased asthma duration, decreased eosinophil count, and lung function in EOA patients ( p <0.05). An increase in PM 2.5 was associated with decreased lung function and ACT score in LOA patients. An increase in NO 2 was associated with increased eosinophil count and decreased lung function in EOA patients ( p <0.05). An increase in O 3 was associated with decreased lung function in LOA patients ( p <0.05). In addition, associations of TRAP with age of onset and eosinophil counts were mainly observed in both EOA and LOA patients with allergic sensitization, and an association with ACT was mainly observed in LOA patients without allergic sensitization. Conclusion The impact of TRAP on age of onset, eosinophil count, and lung function in EOA patients, and ACT in LOA patients, was affected by the status of allergic sensitization.

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confidence: 62%

Different Impacts of Traffic-Related Air Pollution on Early-Onset and Late-Onset Asthma

Lin,

Makrufardi,

Tung

et al. 2024

JAA

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Impacts of intrauterine and postnatal exposure to air pollution on preschool children's asthma: A key role in cumulative exposure

Lu,

Wang,

Liao

et al. 2023

Building and Environment

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Associations between house dust mite concentrations in bedroom dust in Northern China and childhood asthma, rhinitis and eczema

Wan,

Sun,

Luo

et al. 2024

Building and Environment

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Early life exposure to outdoor air pollution and indoor environmental factors on the development of childhood allergy from early symptoms to diseases

Cited by 15 publications

References 75 publications

Different Impacts of Traffic-Related Air Pollution on Early-Onset and Late-Onset Asthma

Different Impacts of Traffic-Related Air Pollution on Early-Onset and Late-Onset Asthma

Impacts of intrauterine and postnatal exposure to air pollution on preschool children's asthma: A key role in cumulative exposure

Associations between house dust mite concentrations in bedroom dust in Northern China and childhood asthma, rhinitis and eczema

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