Early-Life Exposure to Traffic-related Air Pollution and Lung Function in Adolescence

Schultz, Erica S.; Hallberg, Jenny; Bellander, Tom; Bergström, Anna; Bottai, Matteo; Chiesa, Flaminia; Gustafsson, Per; Gruzieva, Olena; Thunqvist, Per; Pershagen, Göran; Melén, Erik

doi:10.1164/rccm.201505-0928oc

Cited by 123 publications

(119 citation statements)

References 29 publications

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“…Although some studies have also found proportional associations of air pollution with FEV 1 and FVC in a restrictive pattern (8,13), other studies have found a largermagnitude association with FEV 1 than FVC, suggesting an obstructive effect involving the larger airways (9,30,31). Two recent studies that examined long-term PM 2.5 and BC exposure in the Boston area using the same models as the present study found restrictive patterns of effects on adult lung function and lung function decline (21,32).…”

Section: Discussionsupporting

confidence: 43%

“…However, studies by Schultz and colleagues (30,31) of PM 10 exposure in the Stockholm area found that PM 10 exposure in the first year of life was more strongly associated with lung function at age 8 and adolescence than later exposure averages. These studies examined larger particles of PM 10 , which includes PM 2.5 and coarse particles, such as road dust.…”

Section: Discussionmentioning

confidence: 97%

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Lifetime Exposure to Ambient Pollution and Lung Function in Children

Rice

Rifas‐Shiman

Litonjua

et al. 2016

Am J Respir Crit Care Med

121

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Rationale: Few studies have examined associations between exposure to air pollution and childhood lung function after implementation of strict air quality regulations in the 1990s.Objectives: To assess traffic-related pollution exposure and childhood lung function.Methods: We geocoded addresses for 614 mother-child pairs enrolled during pregnancy in the Boston area 1999-2002 and followed them until a mid-childhood visit (median age, 7.7). We calculated the proximity of the home to the nearest major roadway. We estimated first year of life, lifetime, and prior-year exposure to particulate matter with a diameter smaller than 2.5 mm (PM 2.5 ) by a hybrid model using satellite-derived aerosol optical depth, and to black carbon (BC) by a land-use regression model. Measurements and Main Results:Residential proximity to roadway and prior-year and lifetime PM 2.5 and BC exposure were all associated with lower FVC. Associations with FEV 1 were also negative and proportionally similar. Pollution exposures were not associated with the FEV 1 /FVC ratio or bronchodilator response. Compared with distances greater than or equal to 400 m, living less than 100 m from a major roadway was associated with lower FVC (298.6 ml; 2176.3 to 221.0). Each 2 mg/m 3 increment in prior-year PM 2.5 was associated with lower FVC (221.8 ml; 243.9 to 0.2) and higher odds of FEV 1 less than 80% predicted (1.41; 1.03-1.93). Each 0.2 mg/m 3 increment in prior-year BC was associated with a 38.9 ml (270.4 to 27.3) lower FVC.Conclusions: Estimates of long-term exposure to ambient pollution, including proximity to major roadway, PM 2.5 , and BC (a traffic-related PM 2.5 constituent), were associated with lower lung function in this Boston-area cohort of children with relatively low pollution exposures.

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Section: Discussionsupporting

confidence: 43%

Section: Discussionmentioning

confidence: 97%

Lifetime Exposure to Ambient Pollution and Lung Function in Children

Rice

Rifas‐Shiman

Litonjua

et al. 2016

Am J Respir Crit Care Med

121

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“…30 Previous authors have postulated that the detrimental effects of cigarette smoke may overwhelm the adverse consequences of ambient air pollution exposure. 30 A similar phenomenon may drive the suggestion of a differential effect that we observed in ethnic groups with stronger effects from unmeasured healthcare disparities and other confounders compared to the effects due to air pollution. While our study had enough power to assess for associations with our main outcome of interest, our ability to show effect modification by these variables is limited.…”

Section: Discussionmentioning

confidence: 99%

Air pollution and subclinical interstitial lung disease: the Multi-Ethnic Study of Atherosclerosis (MESA) air–lung study

et al. 2017

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We sought to determine whether ambient air pollution is associated with interstitial lung abnormalities (ILA) and high attenuation areas (HAA), which are qualitative and quantitative measurements of subclinical ILD on computed tomography. We performed analyses of 6813 community-based dwellers enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA), a U.S.-based prospective cohort study. We used cohort-specific spatiotemporal models to estimate predictions of ambient pollution (PM2.5, NOx, NO2 and O3) at each home. Participants underwent serial assessment of HAA by cardiac CT-scan and a subset of participants was assessed for ILA using full lung CT scan at 10 year follow-up. We used multivariable logistic regression and linear mixed models adjusted for age, sex, ethnicity, education, tobacco use, scanner technology and study site. The odds of ILA increased 1.62-fold per 40ppb increment in NOx (95%CI 0.97 to 2.71, p-value 0.06), and were strongest in non-smokers (2.60-fold increase per 40ppb increment in NOx, 95% CI 1.20 to 5.61, p-value 0.02). HAA increased by 0.54% per year per 5μg/m3 increment in PM2.5 (95%CI 0.02% to 1.10%, p-value 0.04) and by 0.55% per year per 40ppb increment in NOx (95%CI 0.08% to 1.00%, p-value 0.02). Ambient air pollutants were associated with measurements of subclinical ILD.

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“…22 At both occasions, spirometry was performed according to American Thoracic Society/European Respiratory Society criteria. 23 The highest values of forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV 1 ) were used for analysis.…”

Section: Measurements Of Lung Functionmentioning

confidence: 99%

Lung Function at 8 and 16 Years After Moderate-to-Late Preterm Birth: A Prospective Cohort Study

et al. 2016

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Early-Life Exposure to Traffic-related Air Pollution and Lung Function in Adolescence

Abstract: Exposure to traffic-related air pollution in infancy is negatively associated with FEV1 at age 16 years, leading to increased risk of clinically important deficits.

Cited by 123 publications

References 29 publications

Lifetime Exposure to Ambient Pollution and Lung Function in Children

Lifetime Exposure to Ambient Pollution and Lung Function in Children

Air pollution and subclinical interstitial lung disease: the Multi-Ethnic Study of Atherosclerosis (MESA) air–lung study

Lung Function at 8 and 16 Years After Moderate-to-Late Preterm Birth: A Prospective Cohort Study

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