Early life exposures and risk of adult respiratory disease during 50 years of follow-up

Johansson, Carl J; Nilsson, Peter M.; Ignell, Claes

doi:10.1007/s10654-020-00626-3

Cited by 2 publications

(2 citation statements)

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“…Few studies have investigated COPD or obstructive airway diseases combined. In two Swedish studies, risk of obstructive airway disease was either similar [ 14 ] or higher only for women born preterm compared to full term [ 17 ]. In an Australian study, the risk of COPD at age 53 years was higher for individuals born at GA 28–33 weeks, but not for those born at 34–36 weeks [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…Studies of the risk of adult obstructive airway diseases among preterm born individuals show mixed findings. Many show an association between preterm birth and obstructive airway disease in younger ages, whereas most studies show no association in older ages [8,[12][13][14][15][16]. However, there is evidence of a more prominent risk for asthma in preterm-born women [17], COPD in both women and men [5,6,18], and increased mortality from chronic lung diseases [19] in adulthood.…”

Section: Introductionmentioning

confidence: 99%

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Preterm birth and asthma and COPD in adulthood: a nationwide register study from two Nordic countries

et al. 2023

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Preterm birth affects lungs in several ways but only few studies have follow-up until adulthood. We investigated the association of the entire spectrum of gestational ages with specialist care episodes for obstructive airway disease (asthma and chronic obstructive pulmonary disease, COPD) at age 18–50 years. We used nationwide register data on 706 717 people born 1987–1998 in Finland (4.8% preterm) and 1 669 528 born 1967–1999 in Norway (5.0% preterm). Care episodes of asthma and COPD were obtained from specialised healthcare registers, available in Finland 2005–2016 and in Norway 2008–2017. We used logistic regression to estimate odds ratios (OR) for having a care episode with either disease outcome. Odds of any obstructive airway disease in adulthood were 2–3-fold for those born <28 or 28–31 completed weeks, compared with those born full-term (39–41 completed weeks), persisting after adjustments. For individuals born at 32–33, 34–36 or 37–38 weeks, the odds were 1.1- to 1.5-fold. Associations were similar in the Finnish and the Norwegian data and among people aged 18–29 and 30–50 years. For COPD at age 30–50 years, the OR was 7.44 (95% CI 3.49–15.85) for those born <28 weeks, 3.18 (2.23–4.54) for those born 28–31 weeks, and 2.32 (1.72–3.12) for those born 32–33 weeks. Bronchopulmonary dysplasia in infancy increased the odds further for those born <28 and 32–31 weeks. Preterm birth is a risk factor for asthma and COPD in adulthood. The high odds of COPD calls for diagnostic vigilance when adults born very preterm present with respiratory symptoms.

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Section: Discussionmentioning

confidence: 99%