Early Life Factors Associated with Adult-Onset Systemic Lupus Erythematosus in Women

Parks, Christine G.; D’Aloisio, Aimee A.; Sandler, Dale P.

doi:10.3389/fimmu.2016.00103

Cited by 28 publications

(22 citation statements)

References 32 publications

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“…Strengths of this study include the analyses of multiple types of exposure data and detail on farm-related exposure to pesticides. The observed pesticide associations with RA are consistent with our findings for a related disease, systemic lupus erythematosus, in the same cohort (26). Our results also showed internal consistency for associations of RA with agricultural pesticide and broadcast spray exposures in those with a childhood-farm history.…”

Section: Discussionsupporting

confidence: 90%

Childhood Residential and Agricultural Pesticide Exposures in Relation to Adult-Onset Rheumatoid Arthritis in Women

Parks

D’Aloisio

Sandler

2017

American Journal of Epidemiology

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Farming and pesticide exposure may influence risk of rheumatoid arthritis (RA); the role of early-life pesticide exposure is unknown. The Sister Study includes a US national cohort of women aged 35-74 years (enrolled 2004-2009); we examined childhood pesticide exposure in women in this cohort with adult-onset RA. Cases (n = 424) were compared with 48,919 noncases. Data included pesticide use at the longest childhood residence through age 14 years, farm residence of at least 12 months with agricultural pesticide exposure through age 18 years, and maternal farm experience. Odds ratios and 95% confidence intervals were adjusted for age, race or ethnicity, education, smoking, and childhood socioeconomic factors. Cases with RA reported more frequent and direct (personal) residential pesticide use in childhood (for infrequent/indirect pesticide use, odds ratio (OR) = 1.1; for frequent/direct use, OR = 1.8; P for trend = 0.013). Compared with women without residential farm history, odds of having RA increased for those reporting a childhoodonly farm residence with personal exposure to pesticides used on crops (OR = 1.8, 95% confidence interval: 1.1, 2.9) or livestock (OR = 2.0, 95% confidence interval: 1.2, 3.3). Our findings suggest adult-onset RA may be related to childhood exposure to residential and agricultural pesticides, and support further investigations of lifetime pesticide use in RA. autoimmune diseases; early life; insecticides; pesticides; women's health Abbreviations: aOR, age-adjusted odds ratio; DDT, dichlorodiphenyltrichloroethane; DMARD, disease-modifying antirheumatic drugs; RA, rheumatoid arthritis.

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Section: Discussionsupporting

confidence: 90%

Childhood Residential and Agricultural Pesticide Exposures in Relation to Adult-Onset Rheumatoid Arthritis in Women

Parks

D’Aloisio

Sandler

2017

American Journal of Epidemiology

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“…In our case–control study, we found that residential exposure to pesticides among an urban population of predominantly African-American women was associated with a greater than twofold increased risk of SLE, even after controlling for potential confounders. Our findings demonstrate that previous reports of an association between pesticide exposure and SLE 13–15 may be applicable to urban African-American women, a population at increased risk for this disease.…”

Section: Discussionsupporting

confidence: 72%

“…7–9 Studies of (NZB × NZW) F1 lupus-prone mice have pointed to a role of organochlorine pesticides in the pathogenesis of SLE, 10–12 although the evidence to date in human observational studies has been conflicting. 13–17…”

Section: Introductionmentioning

confidence: 99%

Pesticide exposure and risk of systemic lupus erythematosus in an urban population of predominantly African-American women

Sinnette

et al. 2018

Lupus

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Objective: Past studies have reported associations between pesticide exposure and risk of systemic lupus erythematosus (SLE). Residential pesticide exposure has been less well studied than agricultural exposure. The purpose of this study was to assess SLE risk associated with residential pesticide exposure in an urban population of predominantly African-American women. Methods: Adult women with SLE were identified via six hospital databases and community screening in three neighborhoods in Boston, Massachusetts. Controls were adult women volunteers from the same neighborhoods who were screened for absence of connective tissue disease and anti-nuclear antibodies. Subjects were considered exposed to pesticides if they had ever had an exterminator for an ant, cockroach, or termite problem prior to SLE diagnosis or corresponding reference age in controls. Risks associated with pesticide exposure were analyzed using multivariable logistic regression models, adjusted for sociodemographic factors. Results: We identified 93 SLE subjects and 170 controls, with similar baseline characteristics. Eighty-three percent were African-American. Pesticide exposure was associated with SLE, after controlling for potential confounders (odds ratio 2.24, 95% confidence interval 1.28–3.93). Conclusion: Residential exposure to pesticides in an urban population of predominantly African-American women was associated with increased SLE risk. Additional studies are needed to corroborate these findings.

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“…Two studies have reported that pesticide exposure, both agricultural and residential, is associated with increased risk for SLE(35, 109): a recent study confirmed these findings using a national cohort of women. More frequent pesticide use (e.g., at least monthly, OR 2.3, 95%CI 1.3, 4.1) and having an early and extended childhood farm residence (OR, 1.8; 95%CI 1.1, 3.0) were strongly associated with SLE (110*). Studies suggesting roles of hair dyes and other cosmetics, including lipstick, remain unconfirmed(111).…”

Section: Occupational Factors and Pollutantsmentioning

confidence: 99%

Environmental exposures and the development of systemic lupus erythematosus

Barbhaiya

Costenbader²

2016

Current Opinion in Rheumatology

177

137

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Purpose of Review This review examines evidence relating environmental factors to the development of systemic lupus erythematosus (SLE). Recent findings The strongest epidemiologic evidence exists for the associations of silica, cigarette smoking, oral contraceptives, postmenopausal hormone therapy, and endometriosis, with SLE incidence. Recent studies have also provided robust evidence of the association between alcohol consumption and decreased SLE risk. There are preliminary, conflicting or unsubstantiated data that other factors, including air pollution, ultraviolet light, infections, vaccinations, solvents, pesticides, and heavy metals such as mercury, are related to SLE risk. Biologic mechanisms linking environmental exposures and SLE risk include increased oxidative stress, systemic inflammation and inflammatory cytokine upregulation, and hormonal triggers, as well as epigenetic modifications resulting from exposure that could lead to SLE. Summary Identifying the environmental risk factors related to risk of SLE is essential as it will lead to increased understanding of pathogenesis of this complex disease and will also make risk factor modification possible for those at increased risk.

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Early Life Factors Associated with Adult-Onset Systemic Lupus Erythematosus in Women

Cited by 28 publications

References 32 publications

Childhood Residential and Agricultural Pesticide Exposures in Relation to Adult-Onset Rheumatoid Arthritis in Women

Childhood Residential and Agricultural Pesticide Exposures in Relation to Adult-Onset Rheumatoid Arthritis in Women

Pesticide exposure and risk of systemic lupus erythematosus in an urban population of predominantly African-American women

Environmental exposures and the development of systemic lupus erythematosus

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