Early life fluoxetine treatment causes long-term lean phenotype in skeletal muscle of rats exposed to maternal lard-based high-fat diet

Visco, Diego Bulcão; Manhães-de-Castro, Raul; Silva, Márcia Maria da; Dantas-Alves, Jakssuel Sebastion; Santana, Bárbara Juacy Rodrigues Costa de; Silva, Aline Isabel da; Lagranha, Cláudia Jacques; Toscano, Ana Elisa

doi:10.1016/j.biopha.2020.110727

Cited by 4 publications

(2 citation statements)

References 71 publications

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“…Although the ratio of fat to lean tissue in the adult offspring was unchanged by the maternal diet, there were changes in the overall growth trajectory, comparable to the effects seen in the offspring of dams fed cafeteria ( 59 ) or high-fat diets ( 60 ) . The adult body weight of the offspring of dams fed the DEP and REC diets was approximately 10 % less than that of those fed the AIN diet.…”

Section: Discussionmentioning

confidence: 79%

Diet and deprivation in pregnancy: a rat model to investigate the effects of the maternal diet on the growth of the dam and its offspring

Dasgin,

Hay,

Rees

2023

Br J Nutr

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The offspring of women in the poorest socioeconomic groups in Western societies have an increased risk of developing non-communicable disease in adult life. Deprivation is closely related to the consumption of a diet with an excess of energy (sugar and fat), salt and a shortage of key vitamins. To test the hypothesis that this diet adversely affects the development and long-term health of the offspring, we have formulated two rodent diets, one with a nutrient profile corresponding to the diet of pregnant women in the poorest socioeconomic group (DEP) and a second which incorporated current UK recommendations for the diet in pregnancy (REC). Female rats were fed the experimental diets for the duration of gestation and lactation and the offspring compared with those from a reference group fed the AIN-93G diet. The growth trajectory of DEP and REC offspring were reduced compared to the AIN-93G. The REC offspring diet had a transient increase in adipose reserves at weaning, but by 30 weeks of age the body composition of all three groups were similar. The maternal diet had no effect on the HOMA index or the insulin tolerance of the offspring. Changes in hepatic gene expression in the adult REC offspring were consistent with an increased hepatic utilisation of fatty acids and a reduction in de novo lipogenesis. These results show that despite changes in growth and adiposity maternal metabolic adaptation minimises the adverse consequences of the imbalanced maternal diet on the metabolism of the offspring.

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Section: Discussionmentioning

confidence: 79%

Diet and deprivation in pregnancy: a rat model to investigate the effects of the maternal diet on the growth of the dam and its offspring

Dasgin,

Hay,

Rees

2023

Br J Nutr

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“…All soleus muscle fibres were counted using Mensurim 6 (Jean‐François Madre‐Amiens) software. The cross‐section area (CSA) and perimeter were measured using 500 fibres per animal on Image J (version 1.51p) software (Visco et al, 2020).…”

Section: Methodsmentioning

confidence: 99%

Neonatal kaempferol exposure attenuates gait and strength deficits and prevents altered muscle phenotype in a rat model of cerebral palsy

Visco

Castro

Silva

et al. 2022

Intl J of Devlp Neuroscience

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Cerebral palsy (CP) is characterized by brain damage at a critical period of development of the central nervous system, and, as a result, motor, behavioural and learning deficits are observed in those affected. Flavonoids such as kaempferol have demonstrated potential anti-inflammatory and neuroprotective properties for neurological disorders. This study aimed to assess the effects of neonatal treatment with kaempferol on the body development, grip strength, gait performance and morphological and biochemical phenotype of skeletal muscle in rats subjected to a model of CP. The groups were formed by randomly allocating male Wistar rats after birth to four groups as follows: C = control treated with vehicle, K = control treated with kaempferol, CP = CP treated with vehicle and CPK = CP treated with kaempferol. The model of CP involved perinatal anoxia and sensorimotor restriction of the hind paws during infancy, from the second to the 28th day of postnatal life. Treatment with kaempferol (1 mg/kg) was performed intraperitoneally during the neonatal period. Body weight and length, muscle strength, gait kinetics and Abbreviations: CP, cerebral palsy; LH, left hind paw; PA, perinatal anoxia; p-AKT, phospho-protein kinase B/AKT; p-S6, phospho-ribosomal protein S6; P, postnatal day; RH, right hind paw.

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Combined methylphenidate and fluoxetine treatment in adolescent rats significantly impairs weight gain with minimal effects on skeletal development

Chirokikh¹,

Uddin²,

Areikat³

et al. 2023

Bone

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Early life fluoxetine treatment causes long-term lean phenotype in skeletal muscle of rats exposed to maternal lard-based high-fat diet

Cited by 4 publications

References 71 publications

Diet and deprivation in pregnancy: a rat model to investigate the effects of the maternal diet on the growth of the dam and its offspring

Diet and deprivation in pregnancy: a rat model to investigate the effects of the maternal diet on the growth of the dam and its offspring

Neonatal kaempferol exposure attenuates gait and strength deficits and prevents altered muscle phenotype in a rat model of cerebral palsy

Combined methylphenidate and fluoxetine treatment in adolescent rats significantly impairs weight gain with minimal effects on skeletal development

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