Early-life infection of the airways with Streptococcus pneumoniae exacerbates HDM-induced asthma in a murine model

Peng, Dan; Shi, Yifan; Pang, Jie; Cui, Lele; Xu, Yingjie; Wang, Dan; Li, Yan; Cui, Ye; Chen, Yan; Yuan, Huatang; Qin, Xiaofeng; Lv, Zhe; Zhu, Jun; Corrigan, Chris J.; Wang, Wei; Ying, Sun

doi:10.1016/j.cellimm.2022.104536

Cited by 8 publications

(4 citation statements)

References 36 publications

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“…The latest study also showed that mice infected with Streptococcus pneumonia developed more pronounced airway responses and had a higher level of serum-specific IgE and Th2 cytokines in the lung. It has therefore been shown that early respiratory infection with Streptococcus pneumoniae can exacerbate later allergic airway inflammation and adult-associated asthma caused by house dust mites [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Early exposure to infections increases the risk of allergic rhinitis—a systematic review and meta-analysis

et al. 2023

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Objective The purpose of this study was to provide evidence for early life care by meta-analyzing the relationship between infection during pregnancy and up to 2 years of age and the risk of subsequent allergic rhinitis (AR). Methods Published studies up to April 2022 were systematically searched in PubMed, Embase, Web of Science, Cochrane Library, SinoMed, CNKI, Wanfang Database, and VIP. Literature screening, including quality assessment, was performed, and the effect values (OR, HR, RR) and 95% confidence intervals (95% CI) of infection during pregnancy and up to 2 years of age and allergic rhinitis were extracted from each qualified study. Results In total, 5 studies with a sample size of 82,256 reported the relationship between infection during pregnancy and offspring AR. Meta-analysis showed that maternal infection during pregnancy was associated with an increased risk of childhood AR in offspring (OR = 1.34, 95% CI: 1.08–1.67). Altogether, 13 studies with a sample size of 78,426 reported evidence of an association between infection within 2 years of age and subsequent AR in children. A pooled meta-analysis of all studies showed that early infection within 2 years of age was closely associated with childhood AR (OR = 1.25, 95% CI: 1.12–1.40), especially upper respiratory tract infection (OR = 1.32, 95% CI: 1.06–1.65) and gastrointestinal infections (OR = 1.37, 95% CI: 1.01–1.86), but ear infection showed similar results in the cohort study (OR = 1.13, 95% CI: 1.04–1.22). Conclusion Current evidence suggests that infection during pregnancy, early upper respiratory infection, gastrointestinal infections and ear infection within 2 years of age would increase the risk of AR in children. Therefore, the prevention of infection during pregnancy and in infancy and young children needs to be emphasized.

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Section: Discussionmentioning

confidence: 99%

Early exposure to infections increases the risk of allergic rhinitis—a systematic review and meta-analysis

et al. 2023

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“…However, in asthma patients, this balance is disrupted, leading to the overgrowth of specific pathogenic bacteria. For example, Streptococcus pneumoniae ( 40 ) and Haemophilus influenzae ( 41 ) are frequently increased in the airways of asthma patients. The overgrowth of these pathogens can directly cause infections and release toxins and other harmful substances, further exacerbating airway inflammation.…”

Section: Mechanisms Of Respiratory Microbiota Dysbiosis In Asthmamentioning

confidence: 99%

Cross-domain microbiomes: the interaction of gut, lung and environmental microbiota in asthma pathogenesis

Zhang,

Zheng,

Luo

et al. 2024

Front. Nutr.

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Recent experimental and epidemiological studies underscore the vital interaction between the intestinal microbiota and the lungs, an interplay known as the “gut-lung axis”. The significance of this axis has been further illuminated following the identification of intestinal microbial metabolites, such as short-chain fatty acids (SCFA), as key mediators in setting the tone of the immune system. Through the gut-lung axis, the gut microbiota and its metabolites, or allergens, are directly or indirectly involved in the immunomodulation of pulmonary diseases, thereby increasing susceptibility to allergic airway diseases such as asthma. Asthma is a complex outcome of the interplay between environmental factors and genetic predispositions. The concept of the gut-lung axis may offer new targets for the prevention and treatment of asthma. This review outlines the relationships between asthma and the respiratory microbiome, gut microbiome, and environmental microbiome. It also discusses the current advancements and applications of microbiomics, offering novel perspectives and strategies for the clinical management of chronic respiratory diseases like asthma.

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“…For instance, early life infection with Listeria monocytogen es can cause long term-organ specific alterations in both the innate and adaptive immune system ( 145 ). Similarly, some infections by enteroviruses contribute to the onset of autoimmune diseases, such as diabetes ( 146 – 148 ), while others, like Respiratory syncytial virus (RSV) ( 149 , 150 ), Streptococcus pneumoniae ( 151 ) and Rhinovirus ( 152 , 153 ) show a strong association with increased allergic airway diseases in adulthood.…”

Section: Postnatal Immunitymentioning

confidence: 99%

Development of systemic and mucosal immune responses against gut microbiota in early life and implications for the onset of allergies

Pirker,

Vogl

2024

Front. Allergy

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The early microbial colonization of human mucosal surfaces is essential for the development of the host immune system. Already during pregnancy, the unborn child is prepared for the postnatal influx of commensals and pathogens via maternal antibodies, and after birth this protection is continued with antibodies in breast milk. During this critical window of time, which extends from pregnancy to the first year of life, each encounter with a microorganism can influence children's immune response and can have a lifelong impact on their life. For example, there are numerous links between the development of allergies and an altered gut microbiome. However, the exact mechanisms behind microbial influences, also extending to how viruses influence host-microbe interactions, are incompletely understood. In this review, we address the impact of infants’ first microbial encounters, how the immune system develops to interact with gut microbiota, and summarize how an altered immune response could be implied in allergies.

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Early-life infection of the airways with Streptococcus pneumoniae exacerbates HDM-induced asthma in a murine model

Cited by 8 publications

References 36 publications

Early exposure to infections increases the risk of allergic rhinitis—a systematic review and meta-analysis

Early exposure to infections increases the risk of allergic rhinitis—a systematic review and meta-analysis

Cross-domain microbiomes: the interaction of gut, lung and environmental microbiota in asthma pathogenesis

Development of systemic and mucosal immune responses against gut microbiota in early life and implications for the onset of allergies

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