Early-life intake of major trace elements, bisphenol A, tetrabromobisphenol A and fatty acids: Comparing human milk and commercial infant formulas

Martínez, Mari Ángeles; Castro, Irma; Rovira, Joaquim; Segura, Susana Ares; Rodríguez, Juan M.; Cunha, Sara C.; Casal, Susana; Fernandes, José O.; Schuhmacher, Marta; Nadal, Martí

doi:10.1016/j.envres.2018.11.017

Cited by 41 publications

(38 citation statements)

References 38 publications

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“…Further, a low level of Ni was found in our HM samples, being the Ni concentration lower than that reported in previous studies conducted in Spain ( Martínez et al, 2019 ) and Iran ( Salmani et al, 2016 ) ( Table A2 ). However, investigations conducted in Sweden ( Björklund et al, 2012 ) and Brazil ( Cardoso et al, 2014 ) found Ni levels in HM even lower than observed in the present study ( Table A2 ).…”

Section: Resultscontrasting

confidence: 83%

“…Aluminum is the most abundant metal in the earth's crust (soil, water, and air), as well as the most frequent and highly concentrated element in breast milk ( ATSDR, 2008 ; Bastos et al, 2018 ). However, Al concentration in our HM-baseline and HM-concentrate was lower than that reported by studies conducted in Iran ( Taravati Javad et al, 2018 ) and Spain ( Martínez et al, 2019 ) ( Table A2 ). It is important to note that only a small amount of Al enters the infant's body through breastfeeding ( ATSDR, 2008 ).…”

Section: Resultscontrasting

confidence: 81%

“…In general, breast milk has a low concentration of potentially toxic elements. Importantly, the concentration of the toxic microelements Al, As, Cd, and Pb decrease rapidly and significantly over the stages of lactation ( Chao et al, 2014 ; Martínez et al, 2019 ). Thus, it is expected that mature milk used in our HM-concentrate may be safe for the nutritional support of premature newborns.…”

Section: Resultsmentioning

confidence: 99%

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Essential and toxic elements in human milk concentrate with human milk lyophilizate: A preclinical study

Oliveira

Trevilato

Aragon

et al. 2020

Environmental Research

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Concentrated human milk (HM-concentrate) can be obtained from the simple and inexpensive method of donated breast milk direct lyophilization. A previous study reported that HM-concentrate contains the adequate amount of main macro- and micronutrients for use as a nutritional resource for preterm infants with very low birth weight admitted to neonatal intensive care units. However, further details need to be elucidated about HM-concentrate composition, particularly its content of essential and potentially toxic trace elements. Therefore, this study aimed to determine the concentration of essential and toxic elements in human milk considered baseline (HM-baseline) and HM-concentrate, as well as to quantify changes in concentration of these elements after the HM concentration process. The concentration of Aluminum, Arsenic, Cadmium, Chromium, Iron, Mercury, Manganese, Nickel, Lead, Selenium, Tin, and Thallium was analyzed by inductively coupled plasma-mass spectrometry (ICP-MS). Moreover, Bayesian linear mixed effect models were applied to estimate the mean difference between HM-baseline and HM-concentrate samples. After comparison (HM-concentrate versus HM-baseline), a significant increase in concentration was observed only for Manganese (0.80 μg/L; 95% CrI [0.16; 1.43]) and Selenium (6.74 μg/L; 95% CrI [4.66; 8.86]), while Lead concentration (−6.13 μg/L; 95% CrI [-8.63; −3.61]) decreased. This study provides latest and reliable information about HM composition. After milk concentration by lyophilization, there was a significant increase only in the essential elements Manganese and Selenium. The essential micronutrient content in HM-concentrate was similar or higher than that in preterm mothers' milk, which suggests it is viable for nutritional support of preterm infants. In addition, the low concentrations of potentially toxic elements in HM-concentrate indicates that it is safe for consumption by premature newborns.

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Section: Resultscontrasting

confidence: 83%

Section: Resultscontrasting

confidence: 81%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Essential and toxic elements in human milk concentrate with human milk lyophilizate: A preclinical study

Oliveira

Trevilato

Aragon

et al. 2020

Environmental Research

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“…A previous study on the binding capacity of bisphenol A with erythrocyte proteins (hemoglobin, catalase, and glutathione peroxidase) has shown the presence of various hydrogen bonds of BPA with the proteins [91]. All these results and ours support a recent study that reported the content of free BPA was higher in infant formulas than human milk [92].…”

Section: Bpa In Milk Analysissupporting

confidence: 90%

Ion-Trap Mass Spectrometric Analysis of Bisphenol A Interactions With Titanium Dioxide Nanoparticles and Milk Proteins

2020

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Quantitative analysis of endocrine-disrupting molecules such as bisphenol A (BPA) in freshwater to determine their widespread occurrence in environmental resources has been challenged by various adsorption and desorption processes. In this work, ion trap mass spectrometry (ITMS) analysis of BPA was aimed at studying its molecular interactions with titanium dioxide (TiO2) nanoparticles and milk whey proteins. Addition of sodium formate prevented TiO2 nanoparticles from sedimentation while enhancing the electrospray ionization (ESI) efficiency to produce an abundance of [BPA + Na]+ ions at m/z 251.0. More importantly, the ESI-ITMS instrument could operate properly during a direct infusion of nanoparticles up to 500 μg/mL without clogging the intake capillary. Milk protein adsorption of BPA could decrease the [BPA + Na]+ peak intensity significantly unless the proteins were partially removed by curdling to produce whey, which allowed BPA desorption during ESI for quantitative analysis by ITMS.

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“…O estudo realizado por Martínez et al (2019) com FI comercializadas na Espanha e leite materno demonstrou que os níveis dos minerais e elementos traço − entre eles, Ca, Cu, Fe, K, Mg, Mn, Na e Zn − foram significativamente maiores nas fórmulas, em relação aos verificados no leite materno. Ao observar os resultados por faixa etária, as concentrações de Ca, Fe, K, Mg e Na nas FI para lactentes (0-6 meses) foram estatisticamente menores do que nas amostras de FI de seguimento para lactentes (6-12 meses).…”

Section: Importância Dos Minerais Na Fiunclassified

Uma abordagem dos ensaios in vitro para estimar a absorção dos minerais em fórmulas infantis

Fioravanti

Morgano

2021

Braz. J. Food Technol.

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Resumo A fórmula infantil é a opção de alimento mais recomendada quando a amamentação não é possível. Para o melhor entendimento do comportamento gastrointestinal e da absorção dos nutrientes presentes nas fórmulas infantis, realizam-se estudos que simulam os processos de digestão. Este trabalho teve como objetivo discutir a evolução das fórmulas infantis com foco na avaliação da absorção de Ca, Cu, Fe, K, Mg, Mn, P e Zn, identificando métodos disponíveis para a avaliação de bioacessibilidade e de biodisponibilidade, de forma a melhor entender a absorção desses nutrientes. Para isto, foi realizada uma revisão bibliográfica sobre fórmulas infantis e os métodos in vitro mais utilizados no estudo de minerais, com foco no consumo, na qualidade e nos aspectos tecnológicos. Foi constatada uma tendência mundial no aumento do consumo de fórmulas infantis e verificou-se que estudos de biodisponibilidade e bioacessibilidade de minerais, mesmo que ainda escassos, colaboram para a evolução e o desenvolvimento deste produto, visando a uma aproximação com a composição do leite materno. A pesquisa mostrou que a composição da fórmula infantil vem sendo constantemente aperfeiçoada por revisões das legislações e pela indústria, e que, para a obtenção de uma fórmula infantil com alta capacidade de absorção de nutrientes, devem ser realizados estudos de bioacessibilidade e/ou de biodisponibilidade, pois estes estudos possibilitam uma melhor compreensão da influência dos diferentes ingredientes na absorção dos nutrientes. Os estudos também mostraram que, para uma ingestão mais equilibrada, nas diferentes fases do lactente, são necessárias diferentes composições dos nutrientes nas fórmulas infantis.

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Early-life intake of major trace elements, bisphenol A, tetrabromobisphenol A and fatty acids: Comparing human milk and commercial infant formulas

Cited by 41 publications

References 38 publications

Essential and toxic elements in human milk concentrate with human milk lyophilizate: A preclinical study

Essential and toxic elements in human milk concentrate with human milk lyophilizate: A preclinical study

Ion-Trap Mass Spectrometric Analysis of Bisphenol A Interactions With Titanium Dioxide Nanoparticles and Milk Proteins

Uma abordagem dos ensaios in vitro para estimar a absorção dos minerais em fórmulas infantis

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